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1.Soluble lymphotoxin-beta receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological diseases 有权
标题翻译: 可溶性淋巴毒素-β受体和抗淋巴毒素受体和配体抗体作为治疗免疫疾病的治疗剂公开(公告)号:US07744891B2
公开(公告)日:2010-06-29
申请号:US11891847
申请日:2007-08-13
IPC分类号: A61K39/395
CPC分类号: C07K16/2866 , A61K38/00 , C07K14/7151 , C07K16/241 , C07K16/2878 , C07K2319/00 , Y02A50/414
摘要: Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
摘要翻译: 组合物和方法包括“淋巴毒素 - 受体阻断剂“,其阻断淋巴毒素 - 受体信号传导,并且可用于改变免疫疾病,特别是抗体介导的免疫应答。
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2.Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases 有权
标题翻译: 使用淋巴毒素-β受体阻断剂治疗抗体介导的免疫疾病公开(公告)号:US07255854B1
公开(公告)日:2007-08-14
申请号:US09299139
申请日:1999-04-23
CPC分类号: C07K16/2866 , A61K38/00 , C07K14/7151 , C07K16/241 , C07K16/2878 , C07K2319/00 , Y02A50/414
摘要: Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
摘要翻译: 包含“淋巴毒素-β受体阻断剂”的组合物和方法,其阻断淋巴毒素-β受体信号并且可用于改变免疫疾病,特别是抗体介导的免疫应答。
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3.BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders 有权
标题翻译: BAFF,其抑制剂及其在调节B细胞应答和治疗自身免疫性疾病中的用途公开(公告)号:US09545086B2
公开(公告)日:2017-01-17
申请号:US12061398
申请日:2008-04-02
申请人: Fabienne MacKay , Susan Kalled
发明人: Fabienne MacKay , Susan Kalled
IPC分类号: A61K38/00 , A01K67/027 , C07K14/705 , C07K16/28 , C12N15/85 , A61K39/00
CPC分类号: A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878 , C12N15/8509
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
摘要翻译: 本发明提供了治疗或预防与包含BAFF及其片段,抗体,激动剂和拮抗剂的BAFF的表达相关的病症的方法。
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公开(公告)号:US20150139992A1
公开(公告)日:2015-05-21
申请号:US14452870
申请日:2014-08-06
申请人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
发明人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
IPC分类号: C07K14/715 , C07K16/24
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的新型受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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5.Methods of screening for a compound that inhibits the interaction between BAFF and BCMA 有权
标题翻译: 筛选抑制BAFF和BCMA之间相互作用的化合物的方法公开(公告)号:US08828669B2
公开(公告)日:2014-09-09
申请号:US13401610
申请日:2012-02-21
申请人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
发明人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
IPC分类号: G01N33/53 , A61K39/395 , A61K38/17 , C07K14/705 , A61K39/00
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的新型受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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6.Soluble lymphotoxin-beta receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological diseases 有权
标题翻译: 可溶性淋巴毒素-β受体和抗淋巴毒素受体和配体抗体作为治疗免疫疾病的治疗剂公开(公告)号:US08287874B2
公开(公告)日:2012-10-16
申请号:US12813029
申请日:2010-06-10
IPC分类号: A61K39/395
CPC分类号: C07K16/2866 , A61K38/00 , C07K14/7151 , C07K16/241 , C07K16/2878 , C07K2319/00 , Y02A50/414
摘要: Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signalling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
摘要翻译: 组合物和方法,包括淋巴毒素 - 阻断淋巴细胞生成素的受体阻断剂 受体信号传导,并且可用于改变免疫疾病,特别是抗体介导的免疫应答。
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公开(公告)号:US20080254030A1
公开(公告)日:2008-10-16
申请号:US11814959
申请日:2006-01-27
申请人: Charles Mackay , Fabienne Mackay , Susan Kalled
发明人: Charles Mackay , Fabienne Mackay , Susan Kalled
IPC分类号: A61K39/395 , A61K38/02 , A61K38/16 , A61P37/00
CPC分类号: A61K38/191 , A61K2039/505 , C07K16/2875
摘要: Compositions and methods for treating Th2-mediated disease are provided.
摘要翻译: 提供了治疗Th2介导的疾病的组合物和方法。
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公开(公告)号:US07083785B2
公开(公告)日:2006-08-01
申请号:US10077438
申请日:2002-02-15
申请人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
发明人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
IPC分类号: A61K39/395 , C07K16/28 , C12P21/08
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的新型受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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公开(公告)号:US20060079457A1
公开(公告)日:2006-04-13
申请号:US11249714
申请日:2005-10-14
IPC分类号: A61K38/16
CPC分类号: C07K16/2875
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
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10.BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders 审中-公开
标题翻译: BAFF,其抑制剂及其在调节B细胞应答和治疗自身免疫性疾病中的用途公开(公告)号:US20050244411A1
公开(公告)日:2005-11-03
申请号:US11065669
申请日:2005-02-24
申请人: Fabienne MacKay , Susan Kalled
发明人: Fabienne MacKay , Susan Kalled
IPC分类号: A01K67/027 , A61K38/00 , A61K38/17 , A61K38/19 , A61K39/395 , C07K14/705 , C07K16/28 , C12N15/85
CPC分类号: A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878 , C12N15/8509
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
摘要翻译: 本发明提供了治疗或预防与包含BAFF及其片段,抗体,激动剂和拮抗剂的BAFF的表达相关的病症的方法。
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