公开(公告)号：US06680051B2

公开(公告)日：2004-01-20

申请号：US09933699

申请日：2001-08-20

申请人： Kenneth B. Wagener ,  Timothy E. Hopkins ,  James H. Pawlow ,  Fernando J. Gomez

发明人： Kenneth B. Wagener ,  Timothy E. Hopkins ,  James H. Pawlow ,  Fernando J. Gomez

IPC分类号： A61K31795

CPC分类号： C08G69/10 ,  C08G73/028

摘要： Polymers containing amino acid and/or polypeptide moieties in their backbones or pendant to their backbones are made by metathesis. A method of making an amino acid or polypeptide containing polymer includes the steps of: providing a amino acid, amino alcohol, or polypeptide-containing monomer; forming a reaction mixture by contacting the monomer with an agent capable of catalyzing the polymerization of the monomer into a polymer; and placing the reaction mixture under conditions that result in the formation of the polymer in reaction mixture.

摘要翻译： 在其骨架中含有氨基酸和/或多肽部分或其侧链的聚合物通过复分解制备。 制备含氨基酸或多肽的聚合物的方法包括以下步骤：提供含氨基酸，氨基醇或含多肽的单体; 通过使单体与能够将单体聚合成聚合物的试剂接触来形成反应混合物; 并将反应混合物置于导致反应混合物中形成聚合物的条件下。

公开(公告)号：US06340731B1

公开(公告)日：2002-01-22

申请号：US09298288

申请日：1999-04-23

申请人： Kirk J. Abbey ,  Fernando J. Gomez ,  Kenneth B. Wagener

发明人： Kirk J. Abbey ,  Fernando J. Gomez ,  Kenneth B. Wagener

IPC分类号： C08F3004

CPC分类号： C08G61/12 ,  C07F7/2208 ,  C08G79/00 ,  C08G79/12

摘要： A polymer having a backbone repeat unit that includes at least two metal atoms bonded to each other and only one ethylenically unsaturated functional group wherein the backbone unit preferably has a structure of —C(R3)═C(R3)—[C(R3)(R4)]n—[M(R1)(R2)]a—[C(R3)(R4)]p— wherein n is 0 to 4; a is at least 2; p is 0 to 4; R1 and R2 are each independently selected from hydrogen, halogen, lower alkyl having 4 or fewer carbon atoms, alkenyl having 4 or fewer carbon atoms, or aromatic having one ring; R3 and R4 are each independently selected from hydrogen and lower alkyl having 1 to 4 carbon atoms; and M is a metal atom selected from at least one of Sn, Ge, Pb, Hg, Ni, Pd, Pt, Cr, Fe, Co, Cu and Zn. The polymer has at least 20 weight percent metal, preferably at least 50 weight percent metal, based on the weight of the polymer.

摘要翻译： 具有骨架重复单元的聚合物，其包含彼此键合的至少两个金属原子和仅一个烯属不饱和官能团，其中所述主链单元优选具有其中n为n至4的结构; a至少为2; p为0〜4; R 1和R 2各自独立地选自氢，卤素，具有4个或更少碳原子的低级烷基，具有4个或更少碳原子的烯基或具有一个环的芳族; R 3和R 4各自独立地选自氢和具有1至4个碳原子的低级烷基; 并且M是选自Sn，Ge，Pb，Hg，Ni，Pd，Pt，Cr，Fe，Co，Cu和Zn中的至少一种的金属原子。聚合物具有至少20重量％的金属，优选至少50 重量百分比的金属，基于聚合物的重量。

公开(公告)号：US5847064A

公开(公告)日：1998-12-08

申请号：US807494

申请日：1997-02-27

申请人： Kenneth B. Wagener ,  Patrick S. Wolfe ,  Fernando J. Gomez

发明人： Kenneth B. Wagener ,  Patrick S. Wolfe ,  Fernando J. Gomez

IPC分类号： A01N55/02 ,  A01N55/04 ,  C08F38/00 ,  C08F30/04

CPC分类号： A01N55/02 ,  A01N55/04 ,  C08F38/00

摘要： An organometallic polymer having the following moiety: ##STR1## is disclosed. R.sub.1 and R.sub.2 are independently selected from the group of H, alkyl having 30 or fewer carbons, alkenyl having 30 or fewer carbons, and aromatic having one to ten rings; n=0-30; p=0-30; and M is a metal selected from the group consisting of Sn, Ge, Pb, Hg, Ni, Pd, Pt, Cr, Fe, Co, Cu, and Zn. Most preferably, M is Sn, R.sub.1 and R.sub.2 are n-butyl, n is 3, and p is 3. A preferred antibacterial/antifungal composition may be formed by combining the polymer with a suitable carrier.

摘要翻译： 公开了具有以下部分的有机金属聚合物：。 R 1和R 2独立地选自H，具有30个或更少碳的烷基，具有30个或更少个碳的烯基，以及具有1至10个环的芳族; n = 0-30; p = 0-30; M是选自Sn，Ge，Pb，Hg，Ni，Pd，Pt，Cr，Fe，Co，Cu和Zn的金属。 最优选地，M是Sn，R 1和R 2是正丁基，n是3，p是3.可以通过将聚合物与合适的载体组合来形成优选的抗菌/抗真菌组合物。

公开(公告)号：US07172755B2

公开(公告)日：2007-02-06

申请号：US10314612

申请日：2002-12-09

申请人： Kenneth B. Wagener ,  Timothy E. Hopkins ,  James H. Pawlow ,  Fernando J. Gomez

发明人： Kenneth B. Wagener ,  Timothy E. Hopkins ,  James H. Pawlow ,  Fernando J. Gomez

IPC分类号： A61K31/785 ,  A61K38/00 ,  A61K47/00 ,  C08F4/80 ,  C08F20/00

CPC分类号： C08G69/10 ,  C08G73/028

摘要： Polymers containing amino acid and/or polypeptide moieties in their backbones or pendant to their backbones are made by metathesis. A method of making an amino acid or polypeptide containing polymer includes the steps of: providing a amino acid, amino alcohol, or polypeptide-containing monomer; forming a reaction mixture by contacting the monomer with an agent capable of catalyzing the polymerization of the monomer into a polymer; and placing the reaction mixture under conditions that result in the formation of the polymer in reaction mixture.

摘要翻译： 在其骨架中含有氨基酸和/或多肽部分或其侧链的聚合物通过复分解制备。 制备含氨基酸或多肽的聚合物的方法包括以下步骤：提供含氨基酸，氨基醇或含多肽的单体; 通过使单体与能够将单体聚合成聚合物的试剂接触来形成反应混合物; 并将反应混合物置于导致反应混合物中形成聚合物的条件下。

公开(公告)号：US06545110B2

公开(公告)日：2003-04-08

申请号：US10026025

申请日：2001-12-21

申请人： Kirk J. Abbey ,  Fernando J. Gomez ,  Kenneth B. Wagener

发明人： Kirk J. Abbey ,  Fernando J. Gomez ,  Kenneth B. Wagener

IPC分类号： C08F3004

CPC分类号： C08G61/12 ,  C07F7/2208 ,  C08G79/00 ,  C08G79/12

摘要： A polymer having a backbone repeat unit that includes at least two metal atoms bonded to each other and only one ethylenically unsaturated functional group wherein the backbone unit preferably has a structure of —C(R3)═C(R3)—[C(R3)(R4)]n—[M(R1)(R2)]a—[C(R3)(R4)]p— wherein n is 0 to 4; a is at least 2; p is 0 to 4; R1 and R2 are each independently selected from hydrogen, halogen, lower alkyl having 4 or fewer carbon atoms, alkenyl having 4 or fewer carbon atoms, or aromatic having one ring; R3 and R4 are each independently selected from hydrogen and lower alkyl having 1 to 4 carbon atoms; and M is a metal atom selected from at least one of Sn, Ge, Pb, Hg, Ni, Pd, Pt, Cr, Fe, Co, Cu and Zn. The polymer has at least 20 weight percent metal, preferably at least 50 weight percent metal, based on the weight of the polymer.

摘要翻译： 具有骨架重复单元的聚合物，其包含彼此键合的至少两个金属原子和仅一个烯属不饱和官能团，其中所述主链单元优选具有其中n为n至4的结构; a至少为2; p为0〜4; R 1和R 2各自独立地选自氢，卤素，具有4个或更少碳原子的低级烷基，具有4个或更少碳原子的烯基或具有一个环的芳族; R 3和R 4各自独立地选自氢和具有1至4个碳原子的低级烷基; M是选自Sn，Ge，Pb，Hg，Ni，Pd，Pt，Cr，Fe，Co，Cu和Zn中的至少一种的金属原子。 基于聚合物的重量，聚合物具有至少20重量％的金属，优选至少50重量％的金属。