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8 条记录 (耗时 0.021 秒)

    Diphenyl-pyrazolopyridine derivatives, preparation thereof, and use thereof as nuclear receptor not modulators
    2.
    发明授权
    Diphenyl-pyrazolopyridine derivatives, preparation thereof, and use thereof as nuclear receptor not modulators 有权
    二苯基 - 吡唑并吡啶衍生物，其制备方法及其作为核受体而不是调节剂的用途

    公开(公告)号：US08680096B2

    公开(公告)日：2014-03-25

    申请号：US13513497

    申请日：2010-12-03

    申请人： Florian Auger ,  Luc Even

    发明人： Florian Auger ,  Luc Even

    IPC分类号： A61K31/5377 ,  A61P19/10 ,  A61P35/00 ,  A61P25/16 ,  A61P25/24 ,  A61P25/30 ,  A61P29/00 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention relates to a formula (I), in which R is a hydrogen or halogen atom or a (C1-C6)alkyl group; X is one or more substituents selected from a hydrogen or halogen atom, a (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, cyano, hydroxy, or hydroxy(C1-C6)alkyl group; Y is a hydrogen or halogen atom or a (C1-C6)alkyl group; R1 is an NR2R3 or OR4 group; R2 and R3 independently are a hydrogen atom, a (C1-C6)alkyl, hydroxy(C1-C6)alkyl or oxo(C1-C6)alkyl group or R2 and R3, together with the nitrogen atom supporting the same, form a heterocycle optionally substituted by a (C1-C6)alkyl, hydroxy or oxo group; and R4 is a (C1-C6)alkyl, hydroxy(C1-C6)alkyl, or oxo(C1-C6)alkyl group, in the base or acid addition salt state. Said formula can be used therapeutically for treating or preventing diseases linked to the nuclear receptors Nurr-1, also known as NR4A2, NOT, TINUR, RNR-1, and HZF3.

    摘要翻译： 本发明涉及式（I），其中R是氢或卤原子或（C1-C6）烷基; X是一个或多个选自氢或卤素原子，（C 1 -C 6）烷基，卤代（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，卤代（C 1 -C 6）烷氧基，氰基，羟基或 羟基（C 1 -C 6）烷基; Y是氢或卤素原子或（C1-C6）烷基; R1是NR2R3或OR4基团; R2和R3独立地是氢原子，（C1-C6）烷基，羟基（C1-C6）烷基或氧代（C1-C6）烷基或R2和R3与支持它的氮原子一起形成杂环 任选被（C 1 -C 6）烷基，羟基或氧代基取代; 并且R 4是在碱或酸加成盐状态下的（C 1 -C 6）烷基，羟基（C 1 -C 6）烷基或氧代（C 1 -C 6）烷基。 所述配方可用于治疗或预防与核受体Nurr-1（也称为NR4A2，NOT，TINUR，RNR-1和HZF3）相关的疾病。

    Acetylene derivatives of 5-phenyl-pyrazolopyridine, preparation thereof, and therapeutic use thereof
    4.
    发明授权
    Acetylene derivatives of 5-phenyl-pyrazolopyridine, preparation thereof, and therapeutic use thereof 有权
    5-苯基 - 吡唑并吡啶的乙炔衍生物，其制备及其治疗用途

    公开(公告)号：US08546424B2

    公开(公告)日：2013-10-01

    申请号：US13395819

    申请日：2010-09-17

    申请人： Florian Auger ,  Luc Even

    发明人： Florian Auger ,  Luc Even

    IPC分类号： A61K31/437 ,  A61P25/08 ,  A61P25/00 ,  A61P29/00 ,  A61P25/30 ,  A61P35/00 ,  A61P25/24 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： Compounds of formula (I): in which: R1 and R2 represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl group, R3 represents one or more hydrogen or halogen atoms, X represents from 1 to 4 substituents, identical to or different from one another, chosen from hydrogen, halogen or (C1-C6)alkyl, in the form of the base or of an addition salt with an acid. Therapeutic use and synthetic process.

    摘要翻译： 式（I）化合物：其中：R1和R2彼此独立地表示氢原子或（C1-C6）烷基，R3表示一个或多个氢或卤素原子，X表示1至4个取代基 ，彼此相同或不同，选自氢，卤素或（C1-C6）烷基，其为碱的形式或与酸的加成盐。 治疗用途和合成过程。

    5-PHENYLPYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
    5.
    发明申请
    5-PHENYLPYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF 有权

    公开(公告)号：US20130023554A1

    公开(公告)日：2013-01-24

    申请号：US13496118

    申请日：2010-09-17

    申请人： Florian Auger ,  Danielle De Peretti ,  Luc Even

    发明人： Florian Auger ,  Danielle De Peretti ,  Luc Even

    IPC分类号： C07D471/04 ,  C07F5/02 ,  A61P25/28 ,  A61P25/08 ,  A61P29/00 ,  A61P25/30 ,  A61P19/10 ,  A61P35/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61K31/437 ,  A61P25/00

    CPC分类号： C07D471/06

    摘要： Compounds of formula (I): in which:R1 represents a phenyl group or naphthyl group, optionally substituted by one or more atoms or groups chosen, independently of one another, from: halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)thioalkyl, —S(O)(C1-C6)alkyl, —S(O)2(C1-C6)alkyl, hydroxyl, hydroxy(C1-C6)alkylene, CHO, COOH, (C1-C6)alkoxy(C1-C6)alkyleneoxy, NRaRb, CONRaRb, SO2NRaRb, NRcCORd, OC(O)NRaRb, OCO(C1-C6)alkyl, NRcC(O)ORe or NRcSO2Re; X represents from 1 to 4 substituents which are identical to or different from one another and which are chosen from hydrogen, halogen, (C1-C6)alkyl or (C1-C6)alkoxy, it being possible for the (C1-C6)alkyl to be optionally substituted by one or more groups chosen from a halogen, (C1-C6)alkoxy or hydroxyl; R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group optionally substituted by an Rf group, or a CHO or COOH group; X and R3 can together form, with the carbon atoms which carry them, a carbocycle of 5 to 7 carbon atoms; R4 represents a hydrogen atom or a (C1-C6)alkyl group; Ra and Rb represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl, aryl(C1-C6)alkylene or aryl group; or Ra and Rb together form, with the nitrogen atom which carries them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine or homopiperazine group, this group being optionally substituted by a (C1-C6)alkyl, aryl or aryl(C1-C6)alkylene group; Rc and Rd represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl, aryl(C1-C6)alkylene or aryl group; or Rc and Rd together form a (C2-C5)alkylene group; Re represents a (C1-C6)alkyl, aryl(C1-C6)alkylene or aryl group; or Rc and Re together form a (C2-C5)alkylene group; Rf represents a hydroxyl, oxo, CHO or COOH group, in the form of the base or of an addition salt with an acid.Therapeutic use and synthetic process.

    DIPHENYL-PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF AS NUCLEAR RECEPTOR NOT MODULATORS
    6.
    发明申请
    DIPHENYL-PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF AS NUCLEAR RECEPTOR NOT MODULATORS 有权
    二苯基吡唑并吡啶衍生物，其制备方法及其作为核受体而不是调节剂

    公开(公告)号：US20120245164A1

    公开(公告)日：2012-09-27

    申请号：US13513497

    申请日：2010-12-03

    申请人： Florian Auger ,  Luc Even

    发明人： Florian Auger ,  Luc Even

    IPC分类号： A61K31/437 ,  A61P25/28 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61K31/5377 ,  A61P19/10 ,  A61P35/00 ,  A61P25/16 ,  A61P25/24 ,  A61P25/30 ,  C07F5/02 ,  C07D471/04 ,  A61P29/00

    CPC分类号： C07D471/04

    摘要： The invention relates to a formula (I), in which R is a hydrogen or halogen atom or a (C1-C6)alkyl group; X is one or more substituents selected from a hydrogen or halogen atom, a (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, cyano, hydroxy, or hydroxy(C1-C6)alkyl group; Y is a hydrogen or halogen atom or a (C1-C6)alkyl group; R1 is an NR2R3 or OR4 group; R2 and R3 independently are a hydrogen atom, a (C1-C6)alkyl, hydroxy(C1-C6)alkyl or oxo(C1-C6)alkyl group or R2 and R3, together with the nitrogen atom supporting the same, form a heterocycle optionally substituted by a (C1-C6)alkyl, hydroxy or oxo group; and R4 is a (C1-C6)alkyl, hydroxy(C1-C6)alkyl, or oxo(C1-C6)alkyl group, in the base or acid addition salt state. Said formula can be used therapeutically for treating or preventing diseases linked to the nuclear receptors Nurr-1, also known as NR4A2, NOT, TINUR, RNR-1, and HZF3.

    摘要翻译： 本发明涉及式（I），其中R是氢或卤原子或（C1-C6）烷基; X是一个或多个选自氢或卤素原子，（C 1 -C 6）烷基，卤代（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，卤代（C 1 -C 6）烷氧基，氰基，羟基或 羟基（C 1 -C 6）烷基; Y是氢或卤素原子或（C1-C6）烷基; R1是NR2R3或OR4基团; R2和R3独立地是氢原子，（C1-C6）烷基，羟基（C1-C6）烷基或氧代（C1-C6）烷基或R2和R3与支持它的氮原子一起形成杂环 任选被（C 1 -C 6）烷基，羟基或氧代基取代; 并且R 4是在碱或酸加成盐状态下的（C 1 -C 6）烷基，羟基（C 1 -C 6）烷基或氧代（C 1 -C 6）烷基。 所述配方可用于治疗或预防与核受体Nurr-1（也称为NR4A2，NOT，TINUR，RNR-1和HZF3）相关的疾病。