公开(公告)号：US20110052603A1

公开(公告)日：2011-03-03

申请号：US12444579

申请日：2007-10-05

Applicant: Philippe Bouillet ,  Andreas Strasser ,  Steve Gerondakis ,  Fook Lin Tai ,  Thomas Kaufmann ,  Raffi Gugasyan

Inventor： Philippe Bouillet ,  Andreas Strasser ,  Steve Gerondakis ,  Fook Lin Tai ,  Thomas Kaufmann ,  Raffi Gugasyan

IPC: A61K39/395 ,  C12N5/00 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/45 ,  A61K38/46 ,  A61K38/48 ,  A61P37/06 ,  A61P31/12 ,  A61P1/16 ,  A61P35/00

CPC classification number: A61K38/45 ,  A61K38/482 ,  A61K38/4873

Abstract: The present invention relates generally to a method of modulating tumor necrosis factor-mediated apoptosis and to agents useful for same. More particularly, the present invention contemplates a method of modulating tumor necrosis factor-mediated hepatocyte apoptosis by modulating an intracellular Bim and/or Bid-dependent signalling mechanism. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by aberrant, unwanted or otherwise inappropriate tumor necrosis factor-mediated apoptosis. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject Bim and/or Bid-dependent signalling mechanism.

Abstract translation: 本发明一般涉及调节肿瘤坏死因子介导的细胞凋亡的方法以及可用于其的药剂。 更具体地，本发明考虑通过调节细胞内Bim和/或Bid依赖性信号传导机制来调节肿瘤坏死因子介导的肝细胞凋亡的方法。 本发明的方法尤其可用于治疗和/或预防以异常，不想要或其他不适当的肿瘤坏死因子介导的细胞凋亡为特征的病症。 本发明还涉及用于鉴定和/或设计能够调节受试者Bim和/或Bid依赖性信号传导机制的试剂的方法。