公开(公告)号：US20120031403A1

公开(公告)日：2012-02-09

申请号：US13195885

申请日：2011-08-02

Applicant: Daniela COCCONI ,  Francesca Schiaretti ,  Roberto Bilzi

Inventor： Daniela COCCONI ,  Francesca Schiaretti ,  Roberto Bilzi

IPC: A61K31/44 ,  A61P11/06 ,  A61P11/00 ,  A61M15/00 ,  A61K9/14

CPC classification number: A61K31/44 ,  A61K9/0075 ,  A61K9/145

Abstract: Pharmaceutical formulations in the form of inhalable dry powder comprising particles of a phosphodiesterase-4 inhibitor as active ingredient are useful for the prevention and/or treatment of respiratory diseases, such as asthma and COPD.

Abstract translation: 以含有磷酸二酯酶-4抑制剂颗粒的可吸入干粉形式的药物制剂作为活性成分可用于预防和/或治疗呼吸系统疾病如哮喘和COPD。

公开(公告)号：US09132121B2

公开(公告)日：2015-09-15

申请号：US13195885

申请日：2011-08-02

Applicant: Daniela Cocconi ,  Francesca Schiaretti ,  Roberto Bilzi

Inventor： Daniela Cocconi ,  Francesca Schiaretti ,  Roberto Bilzi

IPC: A61M16/00 ,  A61K31/44 ,  A61K9/00 ,  A61K9/14

CPC classification number: A61K31/44 ,  A61K9/0075 ,  A61K9/145

Abstract: Pharmaceutical formulations in the form of inhalable dry powder comprising particles of a phosphodiesterase-4 inhibitor as active ingredient are useful for the prevention and/or treatment of respiratory diseases, such as asthma and COPD.

Abstract translation: 以含有磷酸二酯酶-4抑制剂颗粒的可吸入干粉形式的药物制剂作为活性成分可用于预防和/或治疗呼吸系统疾病如哮喘和COPD。

公开(公告)号：US20120082727A1

公开(公告)日：2012-04-05

申请号：US13239903

申请日：2011-09-22

Applicant: Daniela Cocconi ,  Massimiliano Dagli Alberi ,  Andrea Busca ,  Francesca Schiaretti

Inventor： Daniela Cocconi ,  Massimiliano Dagli Alberi ,  Andrea Busca ,  Francesca Schiaretti

IPC: A61K9/14 ,  A61M15/00 ,  A61P11/06 ,  A61K31/439 ,  A61P11/00

CPC classification number: A61K9/5015 ,  A61K9/0075 ,  A61K9/5089 ,  A61K31/439 ,  A61K47/12 ,  A61K47/26

Abstract: Addition of magnesium stearate to a powder formulation for inhalation comprising carrier particles and an active ingredient bearing a group susceptible to hydrolysis is useful for inhibiting or reducing the chemical degradation of the active ingredient.

Abstract translation: 向用于吸入的粉末制剂中加入硬脂酸镁可用于抑制或减少活性成分的化学降解，所述粉末制剂包含载体颗粒和具有易于水解的基团的活性成分。

公开(公告)号：US20110308519A1

公开(公告)日：2011-12-22

申请号：US13165955

申请日：2011-06-22

Applicant: Francesca SCHIARETTI

Inventor： Francesca SCHIARETTI

IPC: A61M15/00 ,  A61K31/439

CPC classification number: A61K31/439 ,  A61K9/0075 ,  A61K9/145

Abstract: The invention provides dry powder formulations suitable for the inhalatory administration by means of a dry powder inhaler, comprising an antimuscarinic drug as active ingredient. The invention also provides processes for the preparation of such a formulation and method for the prevention and/or treatment of a wide range of conditions including respiratory disorders by administering such a formulation.

Abstract translation: 本发明提供了适用于通过干粉吸入器吸入给药的干粉制剂，其包含抗毒蕈碱药物作为活性成分。 本发明还提供了制备这种制剂和方法的方法，所述制剂和方法通过施用这种制剂来预防和/或治疗包括呼吸系统疾病在内的广泛的病症。