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    Methods for alleviating deleterious effects of 3-deoxyglucosone
    2.
    发明申请
    Methods for alleviating deleterious effects of 3-deoxyglucosone 审中-公开
    减轻3-脱氧葡萄糖酮有害作用的方法

    公开(公告)号：US20060247155A1

    公开(公告)日：2006-11-02

    申请号：US11478497

    申请日：2006-06-29

    申请人： Truman Brown ,  Francis Kappler

    发明人： Truman Brown ,  Francis Kappler

    IPC分类号： A61K38/16 ,  C07K9/00 ,  A61K31/198 ,  A61K31/7008

    CPC分类号： A61K31/7008 ,  A61K31/00 ,  A61K31/13 ,  A61K31/197 ,  A61K31/198 ,  A61K31/275 ,  A61K31/5375 ,  C07H1/00 ,  C07H19/20 ,  G01N33/66

    摘要： Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway. According to the normal functioning on this pathway, fructose-lysine-3-phosphate (FL3P) is broken down to form free lysine, inorganic phosphate and 3-deoxyglucosone (3DG), the latter being a reactive protein modifying agent. 3DG can be detoxified by reduction to 3-deoxyfructose (3DF), or it can react with endogenous proteins to form advanced glycation end-product modified proteins (AGE-proteins). Also disclosed are therapeutic methods of using such inhibitors to alleviate deleterious effects of 3DG.

    摘要翻译： 公开了一类在新发现的代谢途径中ATP依赖性反应中抑制果糖 - 赖氨酸转化为果糖 - 赖氨酸-3-磷酸的化合物。 根据该途径的正常功能，果糖 - 赖氨酸-3-磷酸（FL3P）被分解形成游离赖氨酸，无机磷酸酯和3-脱氧葡萄糖醛（3DG），后者是反应性蛋白质改性剂。 3DG可以通过还原成3-脱氧果糖（3DF）进行解毒，或者可以与内源蛋白反应形成晚期糖基化终产物修饰蛋白（AGE-蛋白）。 还公开了使用这种抑制剂以减轻3DG的有害作用的治疗方法。

    3-deoxyglucosone and skin
    3.
    发明申请
    3-deoxyglucosone and skin 有权
    3-脱氧葡萄糖酮和皮肤

    公开(公告)号：US20050159383A1

    公开(公告)日：2005-07-21

    申请号：US10966967

    申请日：2004-10-15

    申请人： Annette Tobia ,  Francis Kappler

    发明人： Annette Tobia ,  Francis Kappler

    IPC分类号： A61K8/44 ,  A61K31/00 ,  A61Q19/08 ,  A61K48/00 ,  A61K31/198

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K31/00

    摘要： The invention relates to the discovery that 3-deoxyglucosone (3DG) and other alpha-dicarbonyl sugars associated diseases and disorders are present and produced in the skin. Further, the invention relates to the discovery that amadorase, an enzyme that mediates 3DG synthesis, is also present in the skin. Thus, the invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.

    摘要翻译： 本发明涉及3-脱氧葡萄糖苷（3DG）和其它α-二羰基糖相关疾病和病症在皮肤中的存在和产生的发现。 此外，本发明涉及这样一个发现，即马拉多拉酶，介导3DG合成的酶也存在于皮肤中。 因此，本发明还涉及抑制皮肤中3-脱氧葡萄糖醛和其它α-二羰基糖的产生和功能的方法，从而治疗或预防各种疾病，病症或病症。 此外，本发明涉及治疗与氧化应激相关或介导的各种疾病，病症或病症，因为3DG诱导与由氧化应激引起的炎性反应相关的ROS和AGE。

    3-deoxyglucosone and skin
    5.
    发明授权
    3-deoxyglucosone and skin 有权
    3-脱氧葡萄糖酮和皮肤

    公开(公告)号：US07671019B2

    公开(公告)日：2010-03-02

    申请号：US10966967

    申请日：2004-10-15

    申请人： Annette Tobia ,  Francis Kappler

    发明人： Annette Tobia ,  Francis Kappler

    IPC分类号： A61K38/00

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K31/00

    摘要： The invention relates to the discovery that 3-deoxyglucosone (3DG) and other alpha-dicarbonyl sugars associated diseases and disorders are present and produced in the skin. Further, the invention relates to the discovery that amadorase, an enzyme that mediates 3DG synthesis, is also present in the skin. Thus, the invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.

    摘要翻译： 本发明涉及3-脱氧葡萄糖苷（3DG）和其它α-二羰基糖相关疾病和病症在皮肤中的存在和产生的发现。 此外，本发明涉及这样一个发现，即马拉多拉酶，介导3DG合成的酶也存在于皮肤中。 因此，本发明还涉及抑制皮肤中3-脱氧葡萄糖醛和其它α-二羰基糖的产生和功能的方法，从而治疗或预防各种疾病，病症或病症。 此外，本发明涉及治疗与氧化应激相关或介导的各种疾病，病症或病症，因为3DG诱导与由氧化应激引起的炎性反应相关的ROS和AGE。

    Method for assessing risk of diabetes-associated pathologic conditions and efficacy of therapies for such conditions
    6.
    发明授权
    Method for assessing risk of diabetes-associated pathologic conditions and efficacy of therapies for such conditions 失效
    糖尿病相关病理状况风险评估方法及治疗方法

    公开(公告)号：US5231031A

    公开(公告)日：1993-07-27

    申请号：US568919

    申请日：1990-08-17

    申请人： Benjamin S. Szwergold ,  Truman R. Brown ,  Francis Kappler ,  Aqqaluk Peterson

    发明人： Benjamin S. Szwergold ,  Truman R. Brown ,  Francis Kappler ,  Aqqaluk Peterson

    IPC分类号： G01N33/66

    CPC分类号： G01N33/66 ,  Y10S436/811 ,  Y10T436/143333 ,  Y10T436/163333 ,  Y10T436/24

    摘要： Concentrations of one or more carbohydrates phosphorylated at a secondary hydroxyl, including fructose-3-phosphate and sorbitol-3-phosphate, in biological tissue or cells of diabetic patients are determined by .sup.31 P NMR Spectroscopy, High Performance Liquid Chromatography (HPLC) or other appropriate analytical techniques. Elevated levels of such phosphorylated carbohydrates, relative to a prescribed standard or threshold level, are associated with an increased risk for developing the degenerative complications of diabetes. A method is provided for determining the relative concentrations of such phosphorylated carbohydrates, whereby the relative risk of a patient for the development of diabetic complications and the efficacy of therapeutic intervention in prevention of such complications may be assessed.

    摘要翻译： 通过31P NMR光谱，高效液相色谱（HPLC）或其他适当的方法测定在生物组织或糖尿病患者的细胞中在次羟基磷酸化的包括果糖-3-磷酸和山梨糖醇-3-磷酸的一种或多种碳水化合物的浓度 分析技术。 相对于规定的标准或阈值水平，这些磷酸化碳水化合物的升高水平与发展糖尿病退行性并发症的风险增加有关。 提供了一种用于确定这种磷酸化碳水化合物的相对浓度的方法，由此可以评估患者发展糖尿病并发症的相对风险和治疗干预在预防这种并发症中的功效。

    Methods for alleviating deleterious effects of 3-deoxyglucosone
    7.
    发明授权
    Methods for alleviating deleterious effects of 3-deoxyglucosone 有权
    减轻3-脱氧葡萄糖酮有害作用的方法

    公开(公告)号：US08431527B2

    公开(公告)日：2013-04-30

    申请号：US12911195

    申请日：2010-10-25

    申请人： Truman R. Brown ,  Francis Kappler

    发明人： Truman R. Brown ,  Francis Kappler

    IPC分类号： A61K38/00

    CPC分类号： A61K31/7008 ,  A61K31/00 ,  A61K31/13 ,  A61K31/197 ,  A61K31/198 ,  A61K31/275 ,  A61K31/5375 ,  C07H1/00 ,  C07H19/20 ,  G01N33/66

    摘要： Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway. According to the normal functioning on this pathway, fructose-lysine-3-phosphate (FL3P) is broken down to form free lysine, inorganic phosphate and 3-deoxyglucosone (3DG), the latter being a reactive protein modifying agent. 3DG can be detoxified by reduction to 3-deoxyfructose (3DF), or it can react with endogenous proteins to form advanced glycation end-product modified proteins (AGE-proteins) Also disclosed are therapeutic methods of using such inhibitors to alleviate deleterious effects of 3DG.

    摘要翻译： 公开了一类在新发现的代谢途径中ATP依赖性反应中抑制果糖 - 赖氨酸转化为果糖 - 赖氨酸-3-磷酸的化合物。 根据该途径的正常功能，果糖 - 赖氨酸-3-磷酸（FL3P）被分解形成游离赖氨酸，无机磷酸酯和3-脱氧葡萄糖醛（3DG），后者是反应性蛋白质改性剂。 3DG可以通过还原为3-脱氧果糖（3DF）进行解毒，或者可以与内源蛋白反应形成晚期糖基化终产物修饰蛋白（AGE-蛋白）。还公开了使用这种抑制剂减轻3DG有害作用的治疗方法 。

    3-Deoxyglucosone and skin
    8.
    发明申请
    3-Deoxyglucosone and skin 有权
    3-脱氧葡萄糖酮和皮肤

    公开(公告)号：US20080292568A1

    公开(公告)日：2008-11-27

    申请号：US11818997

    申请日：2007-06-15

    申请人： Annette Tobia ,  Francis Kappler

    发明人： Annette Tobia ,  Francis Kappler

    IPC分类号： A61K31/195 ,  A61K38/02 ,  A61P17/00 ,  A61Q19/02 ,  A61Q17/04

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K31/00

    摘要： The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

    摘要翻译： 本发明涉及从皮肤中除去3-脱氧葡萄糖醛和其它α-二羰基糖的方法。 本发明还涉及抑制皮肤中3-脱氧葡萄糖醛和其他α-二羰基糖的产生和功能的方法。 本发明还涉及治疗3-脱氧葡萄糖醛和其它α-二羰基糖相关疾病和皮肤疾病的方法。

    METHODS FOR ALLEVIATING DELETERIOUS EFFECTS OF 3-DEOXYGLUCOSONE
    9.
    发明申请
    METHODS FOR ALLEVIATING DELETERIOUS EFFECTS OF 3-DEOXYGLUCOSONE 审中-公开
    用于消除3-脱氧胆固醇的去除效应的方法

    公开(公告)号：US20070270335A1

    公开(公告)日：2007-11-22

    申请号：US11834314

    申请日：2007-08-06

    申请人： Truman Brown ,  Francis Kappler

    发明人： Truman Brown ,  Francis Kappler

    IPC分类号： A61K38/16 ,  A61K38/00 ,  A61P3/10 ,  C07K14/00 ,  C07K9/00

    CPC分类号： A61K31/7008 ,  A61K31/00 ,  A61K31/13 ,  A61K31/197 ,  A61K31/198 ,  A61K31/275 ,  A61K31/5375 ,  C07H1/00 ,  C07H19/20 ,  G01N33/66

    摘要： Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway. According to the normal functioning on this pathway, fructose-lysine-3-phosphate (FL3P) is broken down to form free lysine, inorganic phosphate and 3-deoxyglucosone (3DG), the latter being a reactive protein modifying agent. 3DG can be detoxified by reduction to 3-deoxyfructose (3DF), or it can react with endogenous proteins to form advanced glycation end-product modified proteins (AGE-proteins) Also disclosed are therapeutic methods of using such inhibitors to alleviate deleterious effects of 3DG.

    摘要翻译： 公开了一类在新发现的代谢途径中ATP依赖性反应中抑制果糖 - 赖氨酸转化为果糖 - 赖氨酸-3-磷酸的化合物。 根据该途径的正常功能，果糖 - 赖氨酸-3-磷酸（FL3P）被分解形成游离赖氨酸，无机磷酸酯和3-脱氧葡萄糖醛（3DG），后者是反应性蛋白质改性剂。 3DG可以通过还原为3-脱氧果糖（3DF）进行解毒，或者可以与内源蛋白反应形成晚期糖基化终产物修饰蛋白（AGE-蛋白）。还公开了使用这种抑制剂减轻3DG有害作用的治疗方法 。