公开(公告)号：US20060110443A1

公开(公告)日：2006-05-25

申请号：US11246910

申请日：2005-10-07

申请人： Francis Payumo ,  Jill Sherwood ,  Donald Monkhouse ,  Jaedeok Yoo ,  Christopher Gaylo ,  Chen-Chao Wang ,  Michael Cima

发明人： Francis Payumo ,  Jill Sherwood ,  Donald Monkhouse ,  Jaedeok Yoo ,  Christopher Gaylo ,  Chen-Chao Wang ,  Michael Cima

IPC分类号： A61K31/4745 ,  A61K31/198 ,  A61K9/48

CPC分类号： A61K9/2893 ,  A61K9/209 ,  A61K9/2886 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.