公开(公告)号：US20060110443A1

公开(公告)日：2006-05-25

申请号：US11246910

申请日：2005-10-07

申请人： Francis Payumo ,  Jill Sherwood ,  Donald Monkhouse ,  Jaedeok Yoo ,  Christopher Gaylo ,  Chen-Chao Wang ,  Michael Cima

发明人： Francis Payumo ,  Jill Sherwood ,  Donald Monkhouse ,  Jaedeok Yoo ,  Christopher Gaylo ,  Chen-Chao Wang ,  Michael Cima

IPC分类号： A61K31/4745 ,  A61K31/198 ,  A61K9/48

CPC分类号： A61K9/2893 ,  A61K9/209 ,  A61K9/2886 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.

公开(公告)号：US20080064674A1

公开(公告)日：2008-03-13

申请号：US11940046

申请日：2007-11-14

申请人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

发明人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

IPC分类号： A61K31/56 ,  A61M11/00

CPC分类号： A61K9/008 ,  A61K9/12 ,  A61K9/124 ,  A61K31/58 ,  A61K2300/00

摘要： Disclosed are metered dose inhalers having a metering valve to deliver a dose containing an aerosol suspension formulation, said aerosol suspension formulation comprising: an effective amount of Mometasone Furoate, Formoterol or a combination thereof; a suspension medium selected from the group consisting of 1,1,1,2,3,3,3,-heptafluoropropane, 1,1,1,2-tetrafluoroethane; and a solvent that is ethanol; wherein said formulation contains less than about 500 μg of non-volatile residue as measured by ultraviolet spectroscopy.

摘要翻译： 公开了具有计量阀以计量含有气溶胶悬浮液制剂的计量剂量吸入器，所述气溶胶悬浮液制剂包含：有效量的糠酸莫米松，福莫特罗或其组合; 选自1,1,1,2,3,3,3， - 七氟丙烷，1,1,1,2-四氟乙烷的悬浮介质; 和乙醇的溶剂; 其中所述制剂含有通过紫外光谱测量的小于约500杯非挥发性残余物。

公开(公告)号：US20050136009A1

公开(公告)日：2005-06-23

申请号：US10967719

申请日：2004-10-18

申请人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

发明人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

IPC分类号： A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K31/58 ,  A61L9/04 ,  A61M11/00

CPC分类号： A61K9/008 ,  A61K9/12 ,  A61K9/124 ,  A61K31/58 ,  A61K2300/00

摘要： Disclosed are metered dose inhalers having a metering valve to deliver a dose containing an aerosol suspension formulation, said aerosol suspension formulation comprising: an effective amount of Mometasone Furoate, Formoterol or a combination thereof; a suspension medium selected from the group consisting of 1,1,1,2,3,3,3,-heptafluoropropane, 1,1,1,2-tetrafluoroethane; and a solvent that is ethanol; wherein said formulation contains less than about 500 μg of non-volatile residue as measured by ultraviolet spectroscopy.

摘要翻译： 公开了具有计量阀以计量含有气溶胶悬浮液制剂的计量剂量吸入器，所述气溶胶悬浮液制剂包含：有效量的糠酸莫米松，福莫特罗或其组合; 选自1,1,1,2,3,3,3， - 七氟丙烷，1,1,1,2-四氟乙烷的悬浮介质; 和乙醇的溶剂; 其中所述制剂含有通过紫外光谱测量的小于约500杯非挥发性残余物。