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公开(公告)号：US08623606B2
公开(公告)日：2014-01-07
申请号：US12310296
申请日：2007-08-09
IPC分类号： G01N33/53 , C07K14/705
CPC分类号： G01N33/6845 , G01N33/5008 , G01N33/542 , G01N33/6842 , G01N2333/726
摘要： This invention relates to a method of identifying a compound capable of binding to a target domain of a G-protein coupled receptor comprising the steps of: (a) providing a receptor comprising said target domain and a first group linked to said target domain; (b) bringing into contact said receptor of (a) with a test molecule comprising a second group and said compound linked to each other, wherein said first group binds said second group; and (c) determining, subsequent to the binding of said first group to said second group, whether said compound binds to said target domain.
摘要翻译： 本发明涉及鉴定能够结合G蛋白偶联受体的靶结构域的化合物的方法，包括以下步骤：（a）提供包含所述靶结构域和与所述靶结构域连接的第一基团的受体; （b）使（a）的所述受体与包含第二组的测试分子和彼此连接的所述化合物接触，其中所述第一组结合所述第二组; 和（c）在所述第一组与所述第二组的结合之后确定所述化合物是否结合所述靶结构域。
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公开(公告)号：US20090286259A1
公开(公告)日：2009-11-19
申请号：US12310296
申请日：2007-08-09
IPC分类号： G01N33/53 , G01N33/566 , C40B40/10 , C07K14/00 , C07K1/107 , C07H21/00 , C12N15/74 , C12N5/10
CPC分类号： G01N33/6845 , G01N33/5008 , G01N33/542 , G01N33/6842 , G01N2333/726
摘要： This invention relates to a method of identifying a compound capable of binding to a target domain of a G-protein coupled receptor comprising the steps of: (a) providing a receptor comprising said target domain and a first group linked to said target domain; (b) bringing into contact said receptor of (a) with a test molecule comprising a second group and said compound linked to each other, wherein said first group binds said second group; and (c) determining, subsequent to the binding of said first group to said second group, whether said compound binds to said target domain.
摘要翻译： 本发明涉及鉴定能够结合G蛋白偶联受体的靶结构域的化合物的方法，包括以下步骤：（a）提供包含所述靶结构域和与所述靶结构域连接的第一基团的受体; （b）使（a）的所述受体与包含第二组的测试分子和彼此连接的所述化合物接触，其中所述第一组结合所述第二组; 和（c）在所述第一组与所述第二组的结合之后确定所述化合物是否结合所述靶结构域。
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