公开(公告)号：US5112621A

公开(公告)日：1992-05-12

申请号：US559429

申请日：1990-07-26

Applicant: Howard Stevens ,  Maryvonne Chariot ,  Francoise Arnold ,  Gareth Lewis

Inventor： Howard Stevens ,  Maryvonne Chariot ,  Francoise Arnold ,  Gareth Lewis

IPC: A61K9/00 ,  A61K9/22 ,  A61K9/50 ,  A61K9/52 ,  A61K9/58 ,  A61K9/62 ,  A61K31/55 ,  A61K47/30 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61K9/5026 ,  A61K31/55 ,  A61K9/5047

Abstract: A sustained-release pharmaceutical composition which comprises microparticles comprising an active principle, said microparticles being coated with a coating mixture comprising ethyl cellulose and an acrylic resin which is a polymerizate of acrylic and methacrylic ester, having a molecular weight of at least 100,000 and comprising units of formula: ##STR1## wherein: R.sub.1 is hydrogen or methyl,R.sub.2 is methyl or ethyl,R.sub.3 is methyl; andR.sub.4 is --CH.sub.2 --CH.sub.2 N(CH.sub.3).sub.3 Clthe resin containing 5% of trimethylammonium methacrylate chloride units by weight.

Abstract translation: 一种持续释放药物组合物，其包含包含活性成分的微粒，所述微粒被涂覆有包含乙基纤维素和丙烯酸树脂的涂层混合物，所述丙烯酸树脂是丙烯酸和甲基丙烯酸酯的聚合物，其分子量至少为100,000，并且包含单元 其中：R 1是氢或甲基，R 2是甲基或乙基，R 3是甲基; 并且R4是-CH 2 -CH 2 N（CH 3）3 Cl，该树脂含有5重量％的甲基丙烯酸三甲基铵氯化物单元。