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    Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist
    1.
    发明授权
    Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist 失效
    通过联合给予止痛剂量的MU阿片样物质激动剂和κ-2阿片激动剂来产生镇痛协同作用

    公开(公告)号：US06310072B1

    公开(公告)日：2001-10-30

    申请号：US08921187

    申请日：1997-08-29

    申请人： Maree Smith ,  Fraser Ross

    发明人： Maree Smith ,  Fraser Ross

    IPC分类号： A61K31485

    CPC分类号： A61K45/06 ,  A61K31/445 ,  A61K31/485

    摘要： An analgesic composition is disclosed comprising a sub-analgesic dosage of a &mgr;-opioid agonist, optionally in the form of a pharmaceutically acceptable salt, and a sub-analgesic dosage of a &kgr;2-opioid agonist, optionally in the form of a pharmaceutically acceptable salt. There is also disclosed a method for producing analgesia in humans and lower animals which comprises administering concurrently to a human or lower animal in need of such treatment an analgesic composition of the invention.

    摘要翻译： 公开了镇痛组合物，其包含任选呈药物可接受的盐形式的μ-阿片样物质激动剂的次镇痛剂量和任选呈药学上可接受的盐形式的κ-阿片样物质激动剂的次镇痛剂量 。 还公开了一种在人类和低等动物中产生止痛的方法，其包括同时施用本发明的止痛组合物的需要这种治疗的人或低级动物。

    Noise reducing system
    2.
    发明授权
    Noise reducing system 失效
    降噪系统

    公开(公告)号：US5652799A

    公开(公告)日：1997-07-29

    申请号：US635855

    申请日：1996-04-22

    申请人： Colin Fraser Ross ,  Andrew John Langley ,  Graham Paul Eatwell

    发明人： Colin Fraser Ross ,  Andrew John Langley ,  Graham Paul Eatwell

    IPC分类号： G10K11/178 ,  G10K11/16

    CPC分类号： G10K11/1784 ,  G10K2210/108 ,  G10K2210/3027 ,  G10K2210/3032 ,  G10K2210/3042 ,  G10K2210/511

    摘要： An active control system for attenuating tonal noise in a defined region is described. In its most basic form the system includes sensors for generating signals indicative of the residual noise in the region after attenuation and the uncontrolled sound affecting the region, signal processing circuit for processing the generated signals differently depending on the tonal content thereof, an adaptive filter supplied with at least one of the generated signals whose characteristic is controlled by the processing circuitry, a transducer for producing tonal-noise-attenuating disturbance in the region and delay means for delaying signals relating to the uncontrolled noise before or after or during the adaptive filtering. The system finds direct application in a personal headset or ear defender.

    摘要翻译： 描述了用于衰减限定区域中的音调噪声的主动控制系统。 在其最基本的形式中，系统包括用于产生指示衰减后区域中的残余噪声的信号的传感器和影响区域的不受控制的声音的信号处理电路，用于根据其音调内容不同地处理所生成的信号，提供自适应滤波器 其特征在于由处理电路控制的产生的信号中的至少一个，用于在该区域中产生音调噪声衰减干扰的传感器，以及用于在自适应滤波之前或期间延迟与不受控噪声相关的信号的延迟装置。 该系统可以直接应用于个人耳机或耳后卫。