公开(公告)号：US20070026064A1

公开(公告)日：2007-02-01

申请号：US11495378

申请日：2006-07-28

申请人： Steven Yoder ,  Brian Korchok ,  Frederick Kettinger

发明人： Steven Yoder ,  Brian Korchok ,  Frederick Kettinger

IPC分类号： A61K9/28 ,  A61K9/20 ,  B05D3/02

CPC分类号： A61K9/2072

摘要： Oral solid dosage forms having holographic markings or identification marks such as a watermark thereon and methods of preparing the same are disclosed. One preferred method of applying an identification mark on a pharmaceutical dosage form described herein includes applying a film coating having a first color to an oral solid dosage form such as a tabet and thereafter applying an identification mark to the film coated oral solid dosage form using an ink which not only contains a pearlescent pigment therein but also has a second color which is substantially similar in color to the first color used for film coating.

摘要翻译： 公开了具有全息标记或诸如水印的识别标记的口服固体剂型及其制备方法。 在本文所述的药物剂型上施用识别标记的一种优选方法包括将具有第一种颜色的膜包衣涂敷到口服固体剂型例如片剂，然后使用包衣口服固体剂型使用识别标记 不仅在其中含有珠光颜料的墨水，而且还具有与用于薄膜包衣的第一颜色基本相似的第二颜色。

公开(公告)号：US20070062385A1

公开(公告)日：2007-03-22

申请号：US11534361

申请日：2006-09-22

申请人： Frederick Kettinger ,  Steven Yoder ,  Joseph Drost

发明人： Frederick Kettinger ,  Steven Yoder ,  Joseph Drost

IPC分类号： B41F17/00

CPC分类号： B41F17/36

摘要： Method for printing on a pharmaceutical tablet by etching a printing plate to form a pattern of etchings therein within an area corresponding to an outline of the tablet, varying the ink-retaining volumes of the etchings in a pre-determined manner and in a direction across the etching pattern from one side to an opposite side, placing ink into the etchings, and transferring ink from the etchings in the etched printing plate onto an outer surface of the tablet. Variations in the ink-retaining volumes of the etchings cause a larger amount of ink to be transferred from etchings having a larger ink-retaining volume than from etchings having a smaller ink-retaining volume during the ink transfer stage. This causes different changes in the color of the outer surface of the tablet dependent on the amount of ink being transferred.

摘要翻译： 通过蚀刻印版以在对应于片剂的轮廓的区域内形成蚀刻图案的方式在药物片剂上进行印刷的方法，以预定的方式和横向的方向改变蚀刻的油墨保持体积 蚀刻图案从一侧到相对侧，将油墨放入蚀刻中，以及将油墨从蚀刻印刷板中的蚀刻转移到片剂的外表面上。 蚀刻墨水保持体积的变化导致更大量的墨水从具有较大墨水保留体积的蚀刻物转移到比在墨水转移阶段期间具有较小墨水保持体积的蚀刻物。 这导致片剂的外表面的颜色的不同变化取决于正在转印的油墨的量。

公开(公告)号：US20060226234A1

公开(公告)日：2006-10-12

申请号：US10560368

申请日：2004-06-10

申请人： Frederick Kettinger ,  Charles Fields ,  Thomas Farrell

发明人： Frederick Kettinger ,  Charles Fields ,  Thomas Farrell

IPC分类号： G06K19/00

CPC分类号： A61J3/007 ,  A61J3/005 ,  A61J2200/30 ,  A61J2205/10 ,  A61J2205/20 ,  A61J2205/40 ,  A61J2205/50 ,  A61K9/2072 ,  B41F17/001 ,  B41F17/36 ,  B41M1/26 ,  B41M1/40 ,  B41M5/0047 ,  G06K19/06037

摘要： Oral solid dosage forms such as tablets having overt, printed or etched markings as well as optional covert markings are disclosed. The markings can be rapidly identified to authenticate a dosage form and/or drug contained therein. The inventive dosage forms include a core portion having sufficiently low friability to receive a printed or etched marking on a surface thereof, and a readable or detectable printed or etched marking on the surface of the core which provides information allowing the identification/authentication of the oral dosage form. In preferred aspects of this embodiment, a bar code, more preferably, a 2D data matrix bar code is printed or etched on a debossed region on the surface of the solid dose form. Methods of preparing the marked dosage forms and methods of identifying and/or authenticating solid dosage forms are also disclosed.

摘要翻译： 公开了口服固体剂型，例如具有明显，印刷或蚀刻标记的片剂以及任选的隐蔽标记。 可以快速鉴定标记以验证其中所含的剂型和/或药物。 本发明的剂型包括具有足够低的易碎性以在其表面上接受印刷或蚀刻标记的芯部分，以及在芯的表面上的可读或可检测的印刷或蚀刻标记，其提供允许口头识别/认证的信息 剂型 在该实施例的优选方面，条形码，更优选地，2D数据矩阵条形码被印刷或蚀刻在固体剂量形式的表面上的凹陷区域上。 还公开了制备标记剂型的方法和鉴定和/或认证固体剂型的方法。