公开(公告)号：US4150100A

公开(公告)日：1979-04-17

申请号：US915327

申请日：1978-06-13

申请人： Frederick R. Kettinger ,  James A. Laudone ,  Richard H. Pierce

发明人： Frederick R. Kettinger ,  James A. Laudone ,  Richard H. Pierce

IPC分类号： B01J29/04 ,  C01B39/16 ,  C01B33/28

CPC分类号： C01B33/2823 ,  Y10S423/24

摘要： Zeolite NaA can be produced with a very short crystallization time, if an alumino-silicate gel of particular properties is prepared and heated at about 95.degree. C. The gel which is prepared by combining solutions of sodium aluminate and sodium silicate must contain a limited amount of water, be of a single phase and having a high viscosity. Gels of this nature can be heated for a fraction of an hour to yield essentially completely crystallized Zeolite NaA with no crystalline impurities.

摘要翻译： 如果制备特定性质的铝硅酸盐凝胶并在约95℃下加热，则可以以非常短的结晶时间生产沸石NaA。通过组合铝酸钠和硅酸钠溶液制备的凝胶必须含有限量 的水，是单相并且具有高粘度。 这种性质的凝胶可以加热一小时，以产生基本上完全结晶的沸石NaA，没有结晶杂质。

公开(公告)号：US20100303735A1

公开(公告)日：2010-12-02

申请号：US12682872

申请日：2008-08-14

申请人： Steven L. Yoder ,  Frederick R. Kettinger ,  Marc Dolbier

发明人： Steven L. Yoder ,  Frederick R. Kettinger ,  Marc Dolbier

IPC分类号： A61K9/44 ,  C08J7/18 ,  C23C16/52 ,  B29C35/08

CPC分类号： A61K9/2893 ,  A61K9/2072 ,  A61K9/288 ,  A61K9/2886 ,  A61K9/4891

摘要： Methods and arrangements for forming a color gradient on a pharmaceutical dosage forms such as tablets are disclosed. In preferred aspects of the invention, a coating layer is applied to a tablet core so that the coating layer is different from the color of the tablet core. The coating layer is etched by one or more lasers to remove selected portions thereof and reveal the core. Removal of selected portions of the coating layer, while other portions remain unetched by the laser(s), causes a variation in the color of the coating layer. The color of the tablet core may be visible at locations at which portions of the coating layer have been entirely removed while the color of the coating layer, i.e., the color of any of the color coatings thereof, is visible at locations at which portions of the coating layer have been only partially removed or not removed at all.

摘要翻译： 公开了在药物剂型如片剂上形成色彩梯度的方法和装置。 在本发明的优选方面，将涂层施加到片芯，使得涂层与片芯的颜色不同。 通过一个或多个激光器蚀刻涂层以除去其中的选定部分并露出芯部。 除去涂层的选定部分，同时其它部分保持未被激光扫描，导致涂层颜色的变化。 片芯的颜色可以在涂层的部分被完全去除的位置处可见，同时涂层的颜色，即其任何颜色涂层的颜色在 涂层完全被部分去除或不被去除。

公开(公告)号：US07827911B2

公开(公告)日：2010-11-09

申请号：US11534361

申请日：2006-09-22

申请人： Frederick R. Kettinger ,  Steven L. Yoder ,  Joseph D. Drost

发明人： Frederick R. Kettinger ,  Steven L. Yoder ,  Joseph D. Drost

IPC分类号： B41M1/10

CPC分类号： B41F17/36

摘要： Method for printing on a pharmaceutical tablet by etching a printing plate to form a pattern of etchings therein within an area corresponding to an outline of the tablet, varying the ink-retaining volumes of the etchings in a pre-determined manner and in a direction across the etching pattern from one side to an opposite side, placing ink into the etchings, and transferring ink from the etchings in the etched printing plate onto an outer surface of the tablet. Variations in the ink-retaining volumes of the etchings cause a larger amount of ink to be transferred from etchings having a larger ink-retaining volume than from etchings having a smaller ink-retaining volume during the ink transfer stage. This causes different changes in the color of the outer surface of the tablet dependent on the amount of ink being transferred.

摘要翻译： 通过蚀刻印版以在对应于片剂的轮廓的区域内形成蚀刻图案的方式在药物片剂上进行印刷的方法，以预定的方式和横向的方向改变蚀刻的油墨保持体积 蚀刻图案从一侧到相对侧，将油墨放入蚀刻中，以及将油墨从蚀刻印刷板中的蚀刻转移到片剂的外表面上。 蚀刻墨水保持体积的变化导致更大量的墨水从具有较大墨水保留体积的蚀刻物转移到比在墨水转移阶段期间具有较小墨水保持体积的蚀刻物。 这导致片剂的外表面的颜色的不同变化取决于正在转印的油墨的量。