公开(公告)号：US20100303735A1

公开(公告)日：2010-12-02

申请号：US12682872

申请日：2008-08-14

申请人： Steven L. Yoder ,  Frederick R. Kettinger ,  Marc Dolbier

发明人： Steven L. Yoder ,  Frederick R. Kettinger ,  Marc Dolbier

IPC分类号： A61K9/44 ,  C08J7/18 ,  C23C16/52 ,  B29C35/08

CPC分类号： A61K9/2893 ,  A61K9/2072 ,  A61K9/288 ,  A61K9/2886 ,  A61K9/4891

摘要： Methods and arrangements for forming a color gradient on a pharmaceutical dosage forms such as tablets are disclosed. In preferred aspects of the invention, a coating layer is applied to a tablet core so that the coating layer is different from the color of the tablet core. The coating layer is etched by one or more lasers to remove selected portions thereof and reveal the core. Removal of selected portions of the coating layer, while other portions remain unetched by the laser(s), causes a variation in the color of the coating layer. The color of the tablet core may be visible at locations at which portions of the coating layer have been entirely removed while the color of the coating layer, i.e., the color of any of the color coatings thereof, is visible at locations at which portions of the coating layer have been only partially removed or not removed at all.

摘要翻译： 公开了在药物剂型如片剂上形成色彩梯度的方法和装置。 在本发明的优选方面，将涂层施加到片芯，使得涂层与片芯的颜色不同。 通过一个或多个激光器蚀刻涂层以除去其中的选定部分并露出芯部。 除去涂层的选定部分，同时其它部分保持未被激光扫描，导致涂层颜色的变化。 片芯的颜色可以在涂层的部分被完全去除的位置处可见，同时涂层的颜色，即其任何颜色涂层的颜色在 涂层完全被部分去除或不被去除。