公开(公告)号：US06500466B2

公开(公告)日：2002-12-31

申请号：US09458717

申请日：1999-12-13

Applicant: Peter Werle ,  Friedhelm Merz ,  Judith N. Jørgensen ,  Martin Trageser

Inventor： Peter Werle ,  Friedhelm Merz ,  Judith N. Jørgensen ,  Martin Trageser

IPC: A01N5908

CPC classification number: A61K31/155 ,  A61K9/0014 ,  A61K47/26

Abstract: Powdered mixtures of chlorhexidine base with selected sugar acids or lactones from the group gluconic acid or gluconolactone, lactobionic acid (I), D-galactono-&ggr;-lactone (II), L-mannono-&ggr;-lactone (III), D-(−)-gulono-&ggr;-lactone (IV), D-(+)-galacturonic acid (V) and &agr;-D-heptaglucono-&ggr;-lactone (VI). The formulations have extraordinary storage stability. New chlorhexidine salts with sugar acid anions based on (I) to (VI) and aqueous solutions of these are also described. The formulations, solutions and pure salts are used as disinfectants and to prepare disinfectants.

Abstract translation: 葡萄糖酸或葡萄糖酸内酯，乳糖酸（I），D-半乳糖-γ-内酯（II），L-甘露聚-γ-内酯（III），D-（ - ） - gulono-γ-内酯（IV），D - （+） - 半乳糖醛酸（V）和α-D-七葡糖基-γ-内酯（VI）。 该配方具有非凡的储存稳定性。 还描述了基于（I）至（VI）的糖酸阴离子和它们的水溶液的新的氯己定盐。 制剂，溶液和纯盐用作消毒剂并制备消毒剂。

公开(公告)号：US08642790B2

公开(公告)日：2014-02-04

申请号：US12031983

申请日：2008-02-15

Applicant: Dietmar Reichert ,  Martin Sarich ,  Friedhelm Merz

Inventor： Dietmar Reichert ,  Martin Sarich ,  Friedhelm Merz

IPC: C07D307/34 ,  C07D307/48 ,  C07D307/50

CPC classification number: C07D307/46

Abstract: 5-hydroxymethylfurfural of the formula II is prepared via a 5-acyloxymethylfurfural as an intermediate.

Abstract translation: 式II的5-羟甲基糠醛通过作为中间体的5-酰氧基甲基糠醛制备。

公开(公告)号：US20080200698A1

公开(公告)日：2008-08-21

申请号：US12031983

申请日：2008-02-15

Applicant: Dietmar Reichert ,  Martin Sarich ,  Friedhelm Merz

Inventor： Dietmar Reichert ,  Martin Sarich ,  Friedhelm Merz

IPC: C07D307/48

CPC classification number: C07D307/46

Abstract: 5-hydroxymethylfurfural of the formula II is prepared via a 5-acyloxymethylfurfural as an intermediate.

Abstract translation: 式II的5-羟甲基糠醛通过作为中间体的5-酰氧基甲基糠醛制备。

公开(公告)号：US06844306B2

公开(公告)日：2005-01-18

申请号：US09982240

申请日：2001-10-19

Applicant: Peter Werle ,  Friedhelm Merz ,  Jolanta Habrich

Inventor： Peter Werle ,  Friedhelm Merz ,  Jolanta Habrich

IPC: A61K9/08 ,  A01N25/12 ,  A01N25/34 ,  A01N33/12 ,  A01N37/36 ,  A01N47/44 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K31/14 ,  A61K31/155 ,  A61K47/26 ,  A61P31/00 ,  C11D1/50

CPC classification number: A01N37/36 ,  A01N47/44 ,  A01N43/16 ,  A01N33/12 ,  A01N25/34 ,  A01N25/12 ,  A01N2300/00

Abstract: The invention relates to water-soluble, chlorhexidine-containing compositions having a long shelf life. The compositions are in the form of powder, granules or tablets and consist substantially of (i) a salt of chlorhexidine with 2 moles of a sugar acid and a microbicidally active quaternary ammonium bromide, or of (ii) chlorhexidine, a sugar acid or sugar lactone, with at least 2 moles of sugar acid or sugar lactone being present per mole of chlorhexidine, and a microbicidally active quaternary ammonium bromide. Peferred compositions consist substantially of chlorhexidine digluconate and N-cetyl-N,N,N-trimethylammonium bromide (cetrimide) in a weight ratio of 1:1 to 1:10. The solid compositions are stable, with little or no p-chloroaniline splitting off during storage.

Abstract translation: 本发明涉及具有长保存期限的水溶性含氯己定组合物。 组合物为粉末，颗粒或片剂的形式，并且基本上由（i）洗脱剂与2摩尔糖酸和杀微生物活性季铵溴化物的盐组成，或（ii）氯己定，糖酸或糖 内酯，每摩尔氯己定含有至少2摩尔的糖酸或糖内酯，以及一种杀微生物活性的季铵溴化物。 分批组合物基本上由洗脱剂二葡萄糖酸盐和N-十六烷基-N，N，N-三甲基溴化铵（cetrimide）组成，重量比为1:1至1:10。 固体组合物是稳定的，在储存期间很少或没有分离对氯苯胺。