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公开(公告)号：US20200147058A1
公开(公告)日：2020-05-14
申请号：US16317791
申请日：2017-07-13
IPC分类号： A61K31/437 , A61K31/506 , A61K31/517 , A61K31/44 , A61P35/00
摘要： Inhibitors of native, non-mutated KRAS for use in preventing and/or treating malignant melanoma and/or hepatocellular carcinoma are disclosed. In addition, a KRAS inhibitor is combined with an inhibitor of another factor of the Ras-Raf-MEK-ERK pathway such as a BRAF inhibitor to reach synergistic inhibitory effects and to overcome tumor cell resistance. The disclosure is further directed to pharmaceutical compositions comprising such inhibitor and a pharmaceutically acceptable agent.
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公开(公告)号：US10307744B2
公开(公告)日：2019-06-04
申请号：US15868002
申请日：2018-01-11
发明人： Jakob Albert , Peter Wasserscheid , Nicola Taccardi , Jens Nagengast , Matthias Kehrer , Julian Kadar , Dimitris Ioannis Collias
IPC分类号： B01J27/02 , B01J27/06 , B01J27/16 , B01J31/04 , B01J31/02 , C07C51/377 , C07C59/08 , C07C59/315 , C07C57/04 , C07C51/09
摘要： Catalysts for the dehydration of lactic acid, lactic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof in liquid phase comprising an ionic liquid (IL) and an acid are provided.
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公开(公告)号：US20180133705A1
公开(公告)日：2018-05-17
申请号：US15868002
申请日：2018-01-11
发明人： Jakob Albert , Peter Wasserscheid , Nicola Taccardi , Jens Nagengast , Matthias Kehrer , Julian Kadar , Dimitris Ioannis Collias
IPC分类号： B01J31/02 , C07C51/377 , C07C57/04 , C07C59/08 , C07C59/315
CPC分类号： B01J31/0268 , C07C51/09 , C07C51/377 , C07C57/04 , C07C59/08 , C07C59/315 , C07C2531/24
摘要： Catalysts for the dehydration of lactic acid, lactic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof in liquid phase comprising an ionic liquid (IL) and an acid are provided.
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