公开(公告)号：US20090155279A1

公开(公告)日：2009-06-18

申请号：US12084205

申请日：2006-10-27

申请人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

发明人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

IPC分类号： A61K39/395 ,  C07K14/00 ,  A61K39/104 ,  C07K16/18 ,  C12N5/06

CPC分类号： C07K16/1214 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/52 ,  C07K14/21 ,  G01N33/56911

摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA5158 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.

摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA5158的蛋白质或肽，以及针对其的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。

公开(公告)号：US06713473B1

公开(公告)日：2004-03-30

申请号：US09926355

申请日：2002-02-19

申请人： Naoyuki Nishikawa ,  Masaharu Sugai ,  Kozo Aoki ,  Makoto Suzuki ,  Akihiko Ikegawa ,  Kazunobu Takahashi ,  Fukuichi Ohsawa ,  Naomi Masuda ,  Nobukazu Kakui ,  Jiro Tanaka ,  Yuji Tabata ,  Kenji Asai

发明人： Naoyuki Nishikawa ,  Masaharu Sugai ,  Kozo Aoki ,  Makoto Suzuki ,  Akihiko Ikegawa ,  Kazunobu Takahashi ,  Fukuichi Ohsawa ,  Naomi Masuda ,  Nobukazu Kakui ,  Jiro Tanaka ,  Yuji Tabata ,  Kenji Asai

IPC分类号： A61K31403

CPC分类号： C07D231/12 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/675 ,  C07D209/88 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07F9/5728 ,  C09B57/00

摘要： A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR3—CO—, —CO—NR3— and the like (R3 represents a hydrogen atom, a lower alkyl group, a lower acyl group and the like); M represents an alkylene linking group (a carbon atom constituting the carbon chain may be replaced with a nitrogen atom, an oxygen atom and the like); X represents —S—, —O—, —NR4—, —NR5—CO— and the like (R4 and R5 represent a hydrogen atom, a lower alkyl group and the like) or a single bond; Y represents an alkyl group, an aryl group, an amino group, an aromatic heterocyclic group and the like; R1 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a lower acyl group; and R21, R22 and R23 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like] or a salt thereof. The compound is useful as an active ingredient of medicaments for diseases in which neuropeptide Y is involved, ingestion control for hyperphagia and the like.

摘要翻译： 由式（I）表示的化合物[A表示5-至7-元烃环基团; L代表-NR 3 -CO - ， - CO-NR 3 - 等（R 3表示氢原子，低级烷基，低级酰基等）。 M表示亚烷基连接基（构成碳链的碳原子可以被氮原子，氧原子等取代）; X表示-S - ， - O - ，-NR 4 - ， - NR 5 -CO-等（R 4和R 5表示氢原子，低级烷基等） ）或单一债券; Y表示烷基，芳基，氨基，芳香族杂环基等; R 1表示低级烷基，低级烯基，低级炔基或低级酰基; R 21，R 22和R 23表示氢原子，羟基，低级烷基等〕或其盐。 该化合物可用作其中涉及神经肽Y的疾病的药物的活性成分，用于食欲摄入的摄取控制等。

公开(公告)号：US08084044B2

公开(公告)日：2011-12-27

申请号：US12225821

申请日：2007-03-30

申请人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

发明人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

IPC分类号： A61K39/108

CPC分类号： C07K16/1214 ,  C07K14/21 ,  C07K2317/77

摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA0427 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.

摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA0427的蛋白质或肽，以及用于诊断，预防或治疗与绿脓假单胞菌相关疾病的抗体。

公开(公告)号：US20090117121A1

公开(公告)日：2009-05-07

申请号：US12225821

申请日：2007-03-30

申请人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masahi Kumagai ,  Takashisa Suzuki ,  Keiko Otsuka

发明人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masahi Kumagai ,  Takashisa Suzuki ,  Keiko Otsuka

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K7/00 ,  A61K39/104 ,  G01N33/569 ,  C07K16/18 ,  C12N5/06

CPC分类号： C07K16/1214 ,  C07K14/21 ,  C07K2317/77

摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA0427 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.

摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA0427的蛋白质或肽，以及用于诊断，预防或治疗与绿脓假单胞菌相关疾病的抗体。