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10 条记录 (耗时 0.019 秒)

    AMINATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    2.
    发明申请
    AMINATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 有权
    海马林的胺化衍生物，其制备方法及其应用

    公开(公告)号：US20140206669A1

    公开(公告)日：2014-07-24

    申请号：US14239464

    申请日：2012-08-20

    申请人： Frank Rong ,  Rongzhen Xu ,  Fuwen Xie ,  Hongxi Lai

    发明人： Frank Rong ,  Rongzhen Xu ,  Fuwen Xie ,  Hongxi Lai

    IPC分类号： C07D493/16

    CPC分类号： C07D493/16 ,  C07D491/20

    摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel aminated homoharringtonine derivatives of formula (I) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

    摘要翻译： 本发明属于天然药物和药物化学领域，具体涉及式（I）的新型胺化的同型异亮氨酸衍生物及其药学上可接受的盐，用于制备这些化合物的方法，含有这些化合物的组合物及其用途 在制备抗肿瘤药物。

    TETRANDRINE DERIVATIVES WITH SUBSTITUTED 5-CARBON, PREPARATION METHOD AND USE THEREOF
    3.
    发明申请
    TETRANDRINE DERIVATIVES WITH SUBSTITUTED 5-CARBON, PREPARATION METHOD AND USE THEREOF 有权
    具有取代的5碳的四氢呋喃衍生物，其制备方法和用途

    公开(公告)号：US20140343047A1

    公开(公告)日：2014-11-20

    申请号：US14239759

    申请日：2012-08-20

    申请人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    发明人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    IPC分类号： C07D491/22

    CPC分类号： C07D491/22 ,  C07D491/147 ,  C07D491/18

    摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 5-substituted tetrandrine derivatives of formula (I) and a pharmaceutically acceptable adduct, complex and salt thereof, to a process for the preparation of these compounds, pharmaceutical compositions containing such compounds and their use in preparing antineoplastic medicaments.

    摘要翻译： 本发明属于天然药物和药物化学领域，具体涉及式（I）的新型5-取代四甲基环戊二烯衍生物及其药学上可接受的加合物，其络合物和盐，用于制备这些化合物，药物 含有这些化合物的组合物及其在制备抗肿瘤药物中的用途。

    Tetrandrine derivatives with substituted 5-carbon, preparation method and use thereof
    5.
    发明授权
    Tetrandrine derivatives with substituted 5-carbon, preparation method and use thereof 有权
    具有取代的5碳的替康德林衍生物，其制备方法和用途

    公开(公告)号：US09133207B2

    公开(公告)日：2015-09-15

    申请号：US14239759

    申请日：2012-08-20

    申请人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    发明人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    IPC分类号： C07D491/18 ,  C07D491/22 ,  C07D491/147

    CPC分类号： C07D491/22 ,  C07D491/147 ,  C07D491/18

    摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 5-substituted tetrandrine derivatives of formula (I) and a pharmaceutically acceptable adduct, complex and salt thereof, to a process for the preparation of these compounds, pharmaceutical compositions containing such compounds and their use in preparing antineoplastic medicaments.

    摘要翻译： 本发明属于天然药物和药物化学领域，具体涉及式（I）的新型5-取代四甲基环戊二烯衍生物及其药学上可接受的加合物，其络合物和盐，用于制备这些化合物，药物 含有这些化合物的组合物及其在制备抗肿瘤药物中的用途。

    ACYLATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    6.
    发明申请
    ACYLATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 有权
    HOMOHARRINGTONINE的衍生物衍生物及其制备方法及其应用

    公开(公告)号：US20140303147A1

    公开(公告)日：2014-10-09

    申请号：US14239372

    申请日：2012-08-20

    申请人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    发明人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    IPC分类号： C07D491/147

    CPC分类号： C07D491/147 ,  C07D491/20

    摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel homoharringtonine acylated derivatives of formula (I) and formula (II) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

    摘要翻译： 本发明属于天然药物和药物化学领域，涉及式（I）和式（II）的新型高粱醇丁酰化衍生物及其药学上可接受的盐，涉及制备这些化合物的方法，含有 这些化合物及其在制备抗肿瘤药物中的应用。

    DICARBOXIMIDE DERIVATIVES OF BERBAMINE, THE PREPARATION AND USE THEREOF
    8.
    发明申请
    DICARBOXIMIDE DERIVATIVES OF BERBAMINE, THE PREPARATION AND USE THEREOF 有权
    伯胺的二恶唑衍生物，其制备和用途

    公开(公告)号：US20130158068A1

    公开(公告)日：2013-06-20

    申请号：US13819111

    申请日：2011-08-25

    申请人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    发明人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    IPC分类号： C07D471/04 ,  C07D401/14

    CPC分类号： C07D471/04 ,  C07D401/14 ,  C07D491/16

    摘要： The present invention relates to a novel dicarboximide derivative of berbamine represented by formula I, including, but not limited to, a phthalimide derivative of berbamine and an aromatic heterocyclic dicarboximide derivative of berbamine, or a pharmaceutically acceptable salt thereof, to a process for preparation of the same, to a pharmaceutical composition comprising said compound and to use thereof in manufacture of an antitumor medicament.

    摘要翻译： 本发明涉及由式I表示的伯巴胺的新型二羧酰亚胺衍生物，其包括但不限于柏柏胺的邻苯二甲酰亚胺衍生物和伯巴胺的芳族杂环二甲酰亚胺衍生物或其药学上可接受的盐，用于制备 相同，涉及包含所述化合物的药物组合物及其在制造抗肿瘤药物中的用途。