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公开(公告)号：US5437598A
公开(公告)日：1995-08-01
申请号：US185487
申请日：1994-01-21
申请人： G. Delbert Antwiler
发明人： G. Delbert Antwiler
CPC分类号： B04B13/00 , A61M1/3693 , A61M1/3696 , B04B5/0442 , A61M2205/3306 , B04B2005/0464
摘要： A plasma sequestration system having a volume control system is provided. When a calculated volume of whole blood has been processed, the system switches from a fill to an empty cycle. The termination point is calculated in advance, based on the desired composition of the collected plasma, thus improving process control and product uniformity. The system is automated or partially automated using an optical sensor or marker to monitor the volume of packed red blood cells. When the red cells reach the marker or sensor, a signal is sent to the control system which then calculates the required fill volume. Processing continues until the calculated fill volume is reached, at which time the system automatically stops the collection cycle. The system also provides for two speed operation of the centrifuge as a safeguard against foaming which may result in aerosol formation and blood trauma. Foaming is reduced by reducing centrifuge speed as the packed red blood cells approach the stationary deflector in the centrifuge bowl.
摘要翻译： 提供了具有体积控制系统的血浆固定系统。 当计算出的全血体积已经被处理时，系统从填充切换到空循环。 基于收集的等离子体的所需组成，预先计算终止点，从而改善过程控制和产物均匀性。 该系统使用光学传感器或标记自动化或部分自动化，以监测填充的红细胞的体积。 当红色细胞到达标记或传感器时，将信号发送到控制系统，然后计算所需的填充体积。 处理继续，直到达到计算的填充量，此时系统自动停止收集循环。 该系统还提供离心机的两次速度操作，以防止起泡，从而可能导致气溶胶形成和血液创伤。 当包装的红细胞接近离心机碗中的固定导流板时，通过降低离心机速度来减少发泡。
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公开(公告)号：US5505685A
公开(公告)日：1996-04-09
申请号：US472434
申请日：1995-06-07
申请人： G. Delbert Antwiler
发明人： G. Delbert Antwiler
CPC分类号： B04B13/00 , A61M1/3693 , A61M1/3696 , B04B5/0442 , A61M2205/3306 , B04B2005/0464
摘要： A plasma sequestration system having a volume control system is provided. When a calculated volume of whole blood has been processed, the system switches from a fill to an empty cycle. The termination point is calculated in advance, based on the desired composition of the collected plasma, thus improving process control and product uniformity. The system is automated or partially automated using an optical sensor or marker to monitor the volume of packed red blood cells. When the red cells reach the marker or sensor, a signal is sent to the control system which then calculates the required fill volume. Processing continues until the calculated fill volume is reached, at which time the system automatically stops the collection cycle. The system also provides for two speed operation of the centrifuge as a safeguard against foaming which may result in aerosol formation and blood trauma. Foaming is reduced by reducing centrifuge speed as the packed red blood cells approach the stationary deflector in the centrifuge bowl.
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