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公开(公告)号：US07276537B2
公开(公告)日：2007-10-02
申请号：US11433545
申请日：2006-05-15
IPC分类号： C07C291/04 , A61K47/02 , A61K47/12 , A61P35/00
CPC分类号： C07C225/36 , A61K9/0019 , A61K47/02 , A61K47/12 , C07C291/04 , C07C2603/24
摘要： A compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R′R″ of at least 2 carbon atoms and R′ and R″ are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups, or R′ and R″ together are a C2-6 alkylene group, is formulated so that upon dissolution in aqueous solution the pH of the solution is in the range of 5 to 9. The compound may be in the form of salt with a physiologically acceptable acid having a pKa in the range of −3.0 (minus 3.0) to 9.0
摘要翻译： 式（I）化合物：其中A是具有NH和至少2个碳原子的N（O）R'R“之间的链长的C亚烷基，R'和R”分别选自 C 1-4烷基和C 2-4 2-4羟基烷基和C 2-4 2-4羟基烷基，或者R'和R“一起是 配制C 2-6亚烷基，使得当溶解在水溶液中时，溶液的pH在5至9的范围内。该化合物可以是与生理学上的盐的形式 具有-3.0（减3.0）至9.0范围内的pK 的可接受的酸
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公开(公告)号：US20120059148A1
公开(公告)日：2012-03-08
申请号：US13214862
申请日：2011-08-22
CPC分类号： A61K9/1275 , A61K38/00 , C07K14/775
摘要： Non-naturally occurring lipoprotein particles, process for preparing such particles and uses thereof.
摘要翻译： 非天然存在的脂蛋白颗粒，制备这种颗粒的方法及其用途。
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公开(公告)号：US07074835B2
公开(公告)日：2006-07-11
申请号：US10507483
申请日：2003-03-17
IPC分类号： C07C291/04 , A61K47/02 , A61K47/12 , A61P35/00
CPC分类号： C07C225/36 , A61K9/0019 , A61K47/02 , A61K47/12 , C07C291/04 , C07C2603/24
摘要： A compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R′R″ of at least 2 carbon atoms and R′ and R″ are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups, or R′ and R″ together are a C2-6 alkylene group, is formulated so that upon dissolution in aqueous solution the pH of the solution is in the range of 5 to 9. The compound may be in the form of salt with a physiologically acceptable acid having a pKa in the range of −3.0 (minus 3.0) to 9.0
摘要翻译： 式（I）化合物：其中A是具有NH和至少2个碳原子的N（O）R'R“之间的链长的C亚烷基，R'和R”分别选自 C 1-4烷基和C 2-4 2-4羟基烷基和C 2-4 2-4羟基烷基，或者R'和R“一起是 配制C 2-6亚烷基，使得当溶解在水溶液中时，溶液的pH在5至9的范围内。该化合物可以是与生理学上的盐的形式 具有-3.0（减3.0）至9.0范围内的pK 的可接受的酸
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公开(公告)号：US06670452B2
公开(公告)日：2003-12-30
申请号：US09269533
申请日：1999-06-01
IPC分类号： C07K100
CPC分类号： C07K14/775 , A61K9/1275 , A61K38/00
摘要： Non-naturally occurring receptor competent LDL particle comprising at least one peptide component wherein the said peptide component comprises at least a binding site for an Apo B protein receptor and at least one lipophilic substituent.
摘要翻译： 包含至少一种肽组分的非天然存在的受体感受态LDL颗粒，其中所述肽组分至少包含Apo B蛋白受体的结合位点和至少一个亲脂性取代基。
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