公开(公告)号：US20050204407A1

公开(公告)日：2005-09-15

申请号：US10514316

申请日：2003-05-14

申请人： Titus Kaletta ,  Nathalie Dewulf ,  Geert Karel Plaetinck

发明人： Titus Kaletta ,  Nathalie Dewulf ,  Geert Karel Plaetinck

IPC分类号： A01K67/033 ,  C07K14/435 ,  G01N33/50 ,  G01N33/68

CPC分类号： G01N33/6872 ,  G01N33/5085 ,  G01N2333/43534

摘要： Methods for identifying and developing compounds that interact with voltage-gated potassium channels of the Kv4 family, optionally with auxiliary proteins such as KChiP proteins. Methods for identifying and developing compounds that may interact with voltage-gated potassium channels of the Shal (Kv4) family. Transgenic nematodes of the species Caenorhabditis elegans that are suitable for use in these methods are also described.

摘要翻译： 用于鉴定和开发与Kv4家族的电压门控钾通道相互作用的化合物的方法，任选地与辅助蛋白质如KChiP蛋白质相互作用。 识别和开发可能与Shal（Kv4）家族的电压门控钾通道相互作用的化合物的方法。 还描述了适用于这些方法的秀丽隐杆线虫的转基因线虫。