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1.发明申请CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPUTIC AGENTS 有权用于改进递送治疗药物的共溶剂组合物和方法公开(公告)号：US20110015243A2
公开(公告)日：2011-01-20
申请号：US12205303
申请日：2008-09-05
IPC分类号： A61K31/4168 , A61K31/4166 , C07D405/12
CPC分类号： A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4166 , A61K31/4168
摘要： The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.
摘要翻译： 本发明提供了使用叔丁醇（TBA）共溶剂体系制备和生产低溶解度的药剂的方法。 本发明还提供了使用新型共溶剂体系制备的药物组合物。 在一个实施方案中，本发明提供了制备用于静脉内使用的丹曲林钠（DS）制剂的方法（DS-IV）。 DS-IV产品的这种即时重建对于在手术期间接受恶性高热的患者的药物治疗是一个显着的改善。
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2.发明申请Lofexidine enantiomers for use as a treatment for CNS disease and pathologies and its chiral synthesis 审中-公开Lofexidine对映异构体用作CNS疾病和病理及其手性合成的治疗公开(公告)号：US20080319041A1
公开(公告)日：2008-12-25
申请号：US11376710
申请日：2006-03-14
IPC分类号： A61K31/4164 , C07D233/22
CPC分类号： A61K31/4164 , C07D233/22
摘要： The invention relates to methods for treatment of CNS disease and pathologies using non-racemic mixtures of lofexidine enantiomers. The invention also relates to processes for the manufacture of chirally pure enantiomers of lofexidine.
摘要翻译： 本发明涉及使用非夫洛西定对映异构体的非外消旋混合物治疗CNS疾病和病理的方法。 本发明还涉及制备洛哌啶的手性纯的对映异构体的方法。
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公开(公告)号：US06281251B1
公开(公告)日：2001-08-28
申请号：US09273547
申请日：1999-03-22
IPC分类号： A01N3114
CPC分类号： C07B59/001 , A01N31/14 , C07B2200/05 , C07C43/23 , Y10S424/14 , Y10S514/843 , Y10S514/967
摘要： Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.
摘要翻译： 公开了单碘和二碘化壬烯醇-9衍生物及其使用方法
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4.发明申请公开(公告)号：US20110160261A2
公开(公告)日：2011-06-30
申请号：US12205303
申请日：2008-09-05
IPC分类号： A61K31/4168 , A61K31/4166 , C07D405/12
摘要： The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.
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5.发明申请LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS 审中-公开用于治疗CNS疾病和病理学及其合成的LOFEXIDINE ENANTIMERS公开(公告)号：US20110015246A2
公开(公告)日：2011-01-20
申请号：US11376710
申请日：2006-03-14
申请人： George Digenis , Peter Crooks , Abeer Al-Ghananeem
发明人： George Digenis , Peter Crooks , Abeer Al-Ghananeem
IPC分类号： A61K31/4164 , C07D233/22
CPC分类号： A61K31/4164 , C07D233/22
摘要： The invention relates to methods for treatment of CNS disease and pathologies using non-racemic mixtures of lofexidine enantiomers. The invention also relates to processes for the manufacture of chirally pure enantiomers of lofexidine.
摘要翻译： 本发明涉及使用非夫洛西定对映异构体的非外消旋混合物治疗CNS疾病和病理的方法。 本发明还涉及制备洛哌啶的手性纯的对映异构体的方法。
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