公开(公告)号：US20080119649A1

公开(公告)日：2008-05-22

申请号：US12021246

申请日：2008-01-28

Applicant: George Pettit ,  Mathew Minardi ,  Heidi Rosenberg

Inventor： George Pettit ,  Mathew Minardi ,  Heidi Rosenberg

IPC: C07D295/00 ,  C07D211/02 ,  C07F9/141

CPC classification number: C07C43/23 ,  C07F9/12

Abstract: The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.

Abstract translation: 本发明涉及命名为卤代抑菌素的新化合物。 卤代抑菌素是考布他汀A-3的衍生物，并且包括对人类癌细胞系和小鼠P388白血病显示出癌细胞生长细胞抑制作用的化合物，以及作为微管蛋白聚合抑制剂的活性以及秋水仙碱与 微管蛋白

公开(公告)号：US20070135516A1

公开(公告)日：2007-06-14

申请号：US10580572

申请日：2004-11-17

Applicant: George Pettit ,  Jun-Ping Xu

Inventor： George Pettit ,  Jun-Ping Xu

IPC: A61K31/366 ,  C07D405/02

CPC classification number: C07D407/06 ,  C07D405/06

Abstract: The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 0.001 to

Abstract translation: 已经发现印度洋太平洋海绵茜草（Ircinia ramosa）含有两种功能强大的（GI50 0.001至<0.0001杯/毫升）鼠和人类癌细胞生长抑制剂，本文命名为irciniastatin A和irciniastatin B.两者均分离（10-3至 10-4％的产量）通过癌细胞系生物测定指导技术，并命名为irciniastatins A（1）和B（2）。 通过光谱分析，主要是高分辨率质谱和2D-NMR（主要是APT，HMQC，HMBC和ROESY）的组合的结构阐明显示异常结构1和2。

公开(公告)号：US20070027439A1

公开(公告)日：2007-02-01

申请号：US11491636

申请日：2006-07-24

Applicant: Daniel Durrie ,  George Pettit ,  John Campin

Inventor： Daniel Durrie ,  George Pettit ,  John Campin

IPC: A61F9/008 ,  A61B18/18

CPC classification number: A61F9/00802 ,  A61F9/008 ,  A61F9/00806 ,  A61F9/00836 ,  A61F2009/00846 ,  A61F2009/00872 ,  A61F2009/0088

Abstract: A method for performing wavefront-guided laser surgery on a cornea includes the step of calculating a corneal flap configuration based upon collected anatomical information on an eye and wavefront data on a cornea of the eye. Such data may be collected by, for example, an aberrometer, although this is not intended as a limitation. The calculated configuration is transmitted to a processor in controlling relation to a corneal flap-cutting device. The flap-cutting device is used to create a corneal flap based upon the calculated configuration. A system for performing wavefront-guided laser surgery on a cornea includes a processor for receiving the anatomical information and wavefront data. A software package is adapted to calculate the corneal flap configuration and to control a corneal flap-cutting device to cut a corneal flap commensurate with the calculated corneal flap configuration.

Abstract translation: 用于在角膜上进行波前引导激光手术的方法包括基于眼睛上收集的解剖信息和眼睛角膜上的波前数据计算角膜瓣构造的步骤。 这样的数据可以通过例如像差计来收集，尽管这不是作为限制。 所计算的配置在控制与角膜瓣切割装置的关系中被传送到处理器。 根据计算出的结构，使用襟翼切割装置创建角膜瓣。 用于在角膜上进行波前引导激光手术的系统包括用于接收解剖信息和波前数据的处理器。 软件包适用于计算角膜瓣构造并控制角膜瓣切割装置以切割与计算出的角膜瓣构造相称的角膜。

公开(公告)号：US20060173032A1

公开(公告)日：2006-08-03

申请号：US10546468

申请日：2004-02-19

Applicant: George Pettit ,  John Knight

Inventor： George Pettit ,  John Knight

IPC: C07D471/04 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: Cribrostatin 6, a dark blue cancer cell growth inhibiting constituent of the Republic of Maldives marine sponge Cribrochalina sp. has been isolated, and its structure (shown below) elucidated, based on a combination of RMS, high field (500 MHz, HMBC, and GOESY experiments) 15N, 1H- and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.

Abstract translation: Cribrostatin 6，一种深蓝色的癌细胞生长抑制成分的马尔代夫海洋海绵Cribrochalina sp。 已经被隔离，并且基于RMS，高场（500MHz，HMBC和GOESY实验）15N，1 H和13 C NMR的组合以及X 晶体结构分析。 发现克雷司他汀6也抑制了许多病原菌和真菌的生长。

公开(公告)号：US06679606B2

公开(公告)日：2004-01-20

申请号：US10338234

申请日：2003-01-08

Applicant: John A. Campin ,  Gary P. Gray ,  George Pettit

Inventor： John A. Campin ,  Gary P. Gray ,  George Pettit

IPC: A61B310

CPC classification number: A61B3/1015 ,  A61B3/09

Abstract: An automated, objective method for determining the accommodative range and aberration profile of an eye using a wavefront sensor that iteratively determines the change in accommodation of the lens of an eye.

Abstract translation: 一种用于使用波前传感器确定眼睛的调节范围和像差轮廓的自动客观方法，所述波前传感器迭代地确定眼睛的镜片的适应性的变化。

公开(公告)号：US20050240062A1

公开(公告)日：2005-10-27

申请号：US10510675

申请日：2003-04-10

Applicant: George Pettit ,  Matthew Grealish

Inventor： George Pettit ,  Matthew Grealish

IPC: A61K31/66 ,  C07C41/26 ,  C07C43/20 ,  C07C43/215 ,  C07C43/23 ,  C07F9/12

CPC classification number: C07C43/23 ,  A61K31/66 ,  C07C41/26 ,  C07C41/30 ,  C07F9/12 ,  C07C43/215

Abstract: Described herein are novel compounds having antineoplastic and antimicrobial activity, obtained via structural modifications of resveratrol and combretastatin A-4, methods for synthesis of these compounds, and their use in pharmaceutical composition and for use in the treatment of mammals having cancer. Examples of the novel compounds are: (Z)- and (E)-3,4′,5-trimethioxystilbene (4a, 4b); (Z)- and (E)-3,5-dimethoxy-4′-hydroxystilbene (14c, 14d); (Z)-and (E)-3-hydroxy-4′,5-dimethoxystilbene (14g, 14h);(Z)-and (E)-3,5-dihydroxy-4′-methoxy-stilbene (14k, 14l); sodium resverastatin dibenzyl phosphate ((Z)-3,5-dimethoxy-4-[O-bis(benzyl)phosphoryl]-stilbene) (14m); and sodium resverastatin phosphate (14n).

Abstract translation: 本文描述了通过白藜芦醇和考布他汀A-4的结构修饰获得的具有抗肿瘤和抗微生物活性的新化合物，它们用于合成这些化合物的方法，以及它们在药物组合物中的用途以及用于治疗具有癌症的哺乳动物。 新化合物的实例是：（Z） - 和（E）-3,4'，5-三甲基二氧噻吩（4a，4b）; （Z） - 和（E）-3,5-二甲氧基-4'-羟基茋（14c，14d）; （Z） - 和（E）-3-羟基-4'，5-二甲氧基茋（14g，14h）;（Z） - 和（E）-3,5-二羟基-4'-甲氧基 - 二苯乙烯（14k，14l ）; （（Z）-3,5-二甲氧基-4- [O-双（苄基）磷酰基] - 二苯乙烯钠（14m）; 和雷铂霉素磷酸钠（14n）。

公开(公告)号：US20050176688A1

公开(公告)日：2005-08-11

申请号：US10948926

申请日：2004-09-24

Applicant: George Pettit ,  Mathew Minardi ,  Heidi Rosenberg

Inventor： George Pettit ,  Mathew Minardi ,  Heidi Rosenberg

IPC: A61K31/66 ,  C07C43/23 ,  C07F9/09 ,  C07F9/12

CPC classification number: C07C43/23 ,  C07F9/12

Abstract: The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.

Abstract translation: 本发明涉及命名为卤代抑菌素的新化合物。 卤代抑菌素是考布他汀A-3的衍生物，并且包括对人类癌细胞系和小鼠P388白血病显示出癌细胞生长细胞抑制作用的化合物，以及作为微管蛋白聚合抑制剂的活性以及秋水仙碱与 微管蛋白

公开(公告)号：US20050075516A1

公开(公告)日：2005-04-07

申请号：US10499848

申请日：2002-12-20

Applicant: George Pettit ,  Bryan Moser

Inventor： George Pettit ,  Bryan Moser

IPC: A61K31/665 ,  A61K31/36 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  C07C43/23 ,  C07F9/12 ,  C07F9/655 ,  C07C43/20

CPC classification number: C07F9/65517 ,  C07C43/23 ,  C07F9/12 ,  Y02P20/55

Abstract: The original synthesis of combretastatin A-2 (1a) was modified to provide an efficient scale-up procedure for obtaining this antineoplastic stilbene. Subsequent conversion to a useful prodrug was accomplished by phosphorylation employing in situ formation of dibenzylchlorophosphite followed 30 by cleavage of the benzyl ester protective groups with bromotrimethylsilane to afford phosphoric acid intermediate 11. The latter was immediately treated with sodium methoxide to complete a practical route to the disodium phosphate prodrug (2a). The phosphoric acid precursor (11) of phosphate 2a was employed in a parallel series of reactions to produce a selection of metal and ammonium cation prodrug candidates. Each of the phosphate salts (2a-q) was evaluated with respect to relative solubility behavior, cancer cell growth inhibition, and antimicrobial activity.

Abstract translation: 改变了考布他汀A-2（1a）的原始合成方法，以获得这种抗肿瘤二萜烯的有效放大方法。 随后转化为有用的前体药物是通过使用原位形成二氯苄基亚磷酸酯进行磷酸化，然后通过用溴代三甲基甲硅烷裂解苄酯保护基来提供磷酸中间体11来完成的。后者立即用甲醇钠处理以完成实际路线 磷酸二钠前药（2a）。 磷酸二烷基酯（11）以平行的一系列反应方式使用，以产生金属和铵阳离子前体药物候选物的选择。 关于相对溶解行为，癌细胞生长抑制和抗微生物活性评估磷酸盐（2a-q）中的每一种。

公开(公告)号：US6010227A

公开(公告)日：2000-01-04

申请号：US986201

申请日：1997-12-05

Applicant: Charles E. Crown ,  George Pettit

Inventor： Charles E. Crown ,  George Pettit

IPC: A47F3/00 ,  A47F3/04 ,  F21V23/02 ,  F25D27/00

CPC classification number: F25D27/00 ,  A47F3/001 ,  A47F3/0482 ,  F21V23/02

Abstract: A ballast can having at least one of an opening which faces in a direction other than toward the rear of the refrigeration unit in which it is mounted and a ballast mounted on the can's cover. The ballast can may include resilient members for attaching the can to a refrigeration unit frame.

Abstract translation: 镇流器可以具有面向不同于其安装的制冷单元的后部的方向的开口中的至少一个，以及安装在罐盖上的压载物。 镇流器罐可以包括用于将罐附接到制冷单元框架的弹性构件。

公开(公告)号：US5720540A

公开(公告)日：1998-02-24

申请号：US483245

申请日：1995-06-07

Applicant: Charles E. Crown ,  George Pettit

Inventor： Charles E. Crown ,  George Pettit

IPC: A47F3/00 ,  A47F3/04 ,  F21V23/02 ,  F25D27/00

CPC classification number: F25D27/00 ,  A47F3/001 ,  A47F3/0482 ,  F21V23/02

Abstract: A ballast can having at least one of an opening which faces in a direction other than toward the rear of the refrigeration unit in which it is mounted and a ballast mounted on the can's cover. The ballast can may include resilient members for attaching the can to a refrigeration unit frame.