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公开(公告)号：US5086181A
公开(公告)日：1992-02-04
申请号：US581815
申请日：1990-09-13
IPC分类号： A23K1/16 , C07D213/73 , C07D213/74 , C07D213/75
CPC分类号： C07D213/73 , C07D213/75
摘要： A pyridine derivative of the formula ##STR1## in which A stands for ##STR2## is useful in the preparation of 4-bromo-6-chloro-5-amino-2-pyridyl-ethanolamines, their physiologically tolerated salts and their N-oxides. The 4-bromo-6-chloro-5-amino-2-pyridyl-ethanolamines are useful as yield promoters in animals and as feedstuff additives to achieve higher increases in weight and improved feed utilization.
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2.发明授权2,4-dihalogeno-6-pyridylethanolphenylisopropylamines for shifting the protein-fat ratio of animals in favor of protein 失效2,4-二卤代-6-吡啶基乙醇苯异丙胺，用于转移动物的蛋白质 - 脂肪比，有利于蛋白质
公开(公告)号：US5010091A
公开(公告)日：1991-04-23
申请号：US477272
申请日：1990-02-08
IPC分类号： A61K31/44 , A61K31/4418 , A61P3/06 , C07D213/61 , C07D405/04
CPC分类号： C07D405/04 , C07D213/61
摘要： 2,4-dihalogeno-6-pyridylethanolphenylisopropylamines for shifting the protein-fat ratio of animals in favor of protein, of the formula ##STR1## in which Hal are identical or different and represent fluorine, chlorine or bromine,X represents a direct bond or --CH.sub.2 -- andY represents phenyl, which is substituted by OH, C.sub.1-4 -alkoxy, C.sub.1-4 -alkoxy-C.sub.1-4 -alkoxy, carboxyl, aminocarbonyl, C.sub.1-4 -alkoxycarbonyl, hydroxy-C.sub.1-4 -alkoxy, C.sub.1-4 -alkoxycarbonyl-C.sub.1-4 -alkoxy or phenyl-C.sub.1-4 -alkoxy,or their physiologically tolerated salts.
摘要翻译： 2,4-二卤代-6-吡啶基乙醇苯基异丙基胺，用于使有益于蛋白质的动物的蛋白质 - 脂肪比例转化为其中Hal相同或不同并且表示氟，氯或溴的式（I），X表示 直接键或-CH 2 - ，Y表示被OH，C 1-4 - 烷氧基，C 1-4 - 烷氧基-C 1-4 - 烷氧基，羧基，氨基羰基，C 1-4 - 烷氧基羰基，羟基-C 1-4取代的苯基 - 烷氧基，C 1-4 - 烷氧基羰基-C 1-4 - 烷氧基或苯基-C 1-4 - 烷氧基，或其生理上耐受的盐。
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公开(公告)号：US5216170A
公开(公告)日：1993-06-01
申请号：US677020
申请日：1991-03-28
IPC分类号： C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/80
CPC分类号： C07D213/64 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/80
摘要： A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula ##STR1## in which A represents .dbd.CH-- or .dbd.N--,R.sup.0 represents hydrogen or methyl,R.sup.1 and R.sup.3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the radical --NR.sup.5 R.sup.6,R.sup.4 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NR.sup.7 R.sup.8, or represents the radical COR.sup.9 or the radical --O--Z--R.sup.10,Z represents C.sub.1 -C.sub.10 -alkylene, -alkenylene or alkynylene,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R.sup.5 and R.sup.6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring,R.sup.7 and R.sup.8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl,R.sup.9 represents hydroxyl, alkoxy or the radical --NR.sup.7 R.sup.8,R.sup.10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy,with the substituent R.sup.4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another,or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.
摘要翻译： 一种用于促进家畜生产和控制人和动物肥胖的化合物，其中A表示= CH-或= N-，R0表示氢或甲基，R1和R3各自独立地表示氢， 羟基，卤素，氰基，烷基，卤代烷基，羟基烷基，烷氧基羰基，氨基羰基，一烷基氨基羰基和二烷基氨基羰基，烷氧基，卤代烷氧基，卤代烷硫基，NHSO2-烷基，R2代表氢，羟基，烷氧基或基-NR5R6，R4代表氢，C1- 任选被羟基，卤素，烷氧基，酰氧基或基团-NR 7 R 8取代的C 10 - 烷基，或表示基团COR 9或基团-OZ-R 10，Z表示C 1 -C 10亚烷基， - 亚烯基或亚炔基，R 5表示氢 或烷基，R 6表示氢，烷基，卤代烷基或酰基，或R 5和R 6与相邻的N原子一起形成饱和或不饱和的4-，5-或6-元环，R 7和R 8各自独立地表示氢， 取代的烷基，任选取代的芳基，R 9表示羟基，烷氧基或基团-NR 7 R 8，R 10表示羟基，烷氧基，酰氧基，任选取代的芳氧基或芳烷氧基，式I的吡啶环中的取代基R4和烷基氨基在 相对于彼此的p位置或其生理上耐受的盐，或者如果A表示氮，则任选地其N-氧化物。
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4.发明授权4-bromo-6-chloro-5-amino-2-pyridyl-ethanolamines and their use as yield promoters 失效4-溴-6-氯-5-氨基-2-吡啶基 - 乙醇胺及其作为产率促进剂的用途
公开(公告)号：US4988694A
公开(公告)日：1991-01-29
申请号：US340936
申请日：1989-04-20
IPC分类号： A23K1/16 , C07D213/73 , C07D213/74 , C07D213/75
CPC分类号： C07D213/73 , C07D213/75
摘要： 4-Bromo-6-chloro-5-amino-2-pyridyl-ethanolamines, intermediates for preparation thereof and their use as yield promoters for animals and as feedstuff additives to achieve higher increases in weight and improved feed utilization of the formula ##STR1## in which R.sup.1 stands for hydrogen, alkyl, acyl or substituted silyl,R.sup.2 stands for hydrogen or alkyl,R.sup.3 stands for hydrogen, alkyl, cycloalkyl, substituted alkyl, optionally substituted aralkyl, aryl or heterocyclyl, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are bonded, can stand for an optionally substituted heterocyclic radical,R.sup.4 stands for hydrogen or alkyl andR.sup.5 stands for hydrogen, alkyl, halogenoalkyl or acyl, and their physiologically tolerated salts and their N-oxides have been found.
摘要翻译： 4-溴-6-氯-5-氨基-2-吡啶基 - 乙醇胺，其制备的中间体及其作为动物产率促进剂和作为饲料添加剂的用途，以实现更高的重量增加和改善饲料利用的方法。 其中R1代表氢，烷基，酰基或取代的甲硅烷基，R2代表氢或烷基，R3代表氢，烷基，环烷基，取代烷基，任选取代的芳烷基，芳基或杂环基，或R 2和R 3与氮 可以代表任意取代的杂环基，R4代表氢或烷基，R5代表氢，烷基，卤代烷基或酰基，并且已经发现它们的生理上耐受的盐和它们的N-氧化物。
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5.发明授权
公开(公告)号：US5028617A
公开(公告)日：1991-07-02
申请号：US467593
申请日：1990-01-19
IPC分类号： A23K1/16 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P3/04 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/80
CPC分类号： C07D213/64 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/80
摘要： A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula ##STR1## in which A represents .dbd.CH-- or .dbd.N--,R.sup.0 represents hydrogen or methyl,R.sup.1 and R.sup.3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the radical --NR.sup.5 R.sup.6,R.sup.4 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NH.sup.7 R.sup.8, or represents the radical COR.sup.9 or the radical --O--Z--R.sup.10,Z represents C.sub.1 -C.sub.10 -alkylene, -alkenylene or alkynylene,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R.sup.5 and R.sup.6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring,R.sup.7 and R.sup.8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl,R.sup.9 represents hydroxyl, alkoxy or the radical --NR.sup.7 R.sup.8,R.sup.10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy,with the substituent R.sup.4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another, or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.
摘要翻译： 一种用于促进家畜生产和控制人和动物肥胖的化合物，其中A表示= CH-或= N-，R0表示氢或甲基，R1和R3各自独立地表示氢， 羟基，卤素，氰基，烷基，卤代烷基，羟基烷基，烷氧基羰基，氨基羰基，一烷基氨基羰基和二烷基氨基羰基，烷氧基，卤代烷氧基，卤代烷硫基，NHSO2-烷基，R2代表氢，羟基，烷氧基或基-NR5R6，R4代表氢，C1- 任选被羟基，卤素，烷氧基，酰氧基或基团-NH 7 R 8取代的C 10 - 烷基，或表示基团COR 9或基团-OZ-R 10，Z表示C 1 -C 10 - 亚烷基， - 亚烯基或亚炔基，R 5表示氢 或烷基，R 6表示氢，烷基，卤代烷基或酰基，或R 5和R 6与相邻的N原子一起形成饱和或不饱和的4-，5-或6-元环，R 7和R 8各自独立地表示氢， 取代的烷基，任选取代的芳基，R 9表示羟基，烷氧基或基团-NR 7 R 8，R 10表示羟基，烷氧基，酰氧基，任选取代的芳氧基或芳烷氧基，式I的吡啶环中的取代基R4和烷基氨基在 相对于彼此的p位置或其生理上耐受的盐，或者如果A表示氮，则任选地其N-氧化物。
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