公开(公告)号：US20120232075A1

公开(公告)日：2012-09-13

申请号：US13411450

申请日：2012-03-02

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/4985 ,  A61K31/5377 ,  A61P29/00 ,  A61P19/02 ,  A61P19/10 ,  A61P19/04 ,  A61P1/02 ,  A61P35/04 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P1/16 ,  A61P9/10 ,  A61P9/04 ,  A61P25/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有下列表示的式的新型稠合吡嗪化合物：该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括以非限制性方式 例如炎症，类风湿关节炎等。

公开(公告)号：US09006237B2

公开(公告)日：2015-04-14

申请号：US13411450

申请日：2012-03-02

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/503 ,  A61K31/4985 ,  C07D403/12 ,  C07D407/04 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

公开(公告)号：US08148369B2

公开(公告)日：2012-04-03

申请号：US12151585

申请日：2008-05-07

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/50 ,  A61K31/535 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

公开(公告)号：US20090012078A1

公开(公告)日：2009-01-08

申请号：US12151585

申请日：2008-05-07

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Gregory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Gregory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61K31/4985 ,  A61P19/02 ,  C07D471/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有下列表示的式的新型稠合吡嗪化合物：该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括以非限制性方式 例如炎症，类风湿关节炎等。