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公开(公告)号:US20090227490A1
公开(公告)日:2009-09-10
申请号:US12433028
申请日:2009-04-30
CPC分类号: A61K38/15 , A61K2300/00
摘要: Aplidine and aplidine analogues are of use for the treatment of cancer, in particular in the treatment of leukemias and lymphomas, especially in combination therapies.
摘要翻译: Aplidine和aplidine类似物可用于治疗癌症,特别是治疗白血病和淋巴瘤,特别是联合治疗。
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公开(公告)号:US07683028B2
公开(公告)日:2010-03-23
申请号:US12019705
申请日:2008-01-25
摘要: The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents.
摘要翻译: 本发明涉及新的卡伐拉定抗肿瘤化合物,特别是可用作抗肿瘤剂,抗病毒剂和抗真菌剂的卡拉拉肽F的类似物。
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公开(公告)号:US20090298752A1
公开(公告)日:2009-12-03
申请号:US12342478
申请日:2008-12-23
CPC分类号: A61K31/205 , A61K38/15 , A61K2300/00
摘要: Aplidine demonstrates considerable promise in phase (I) clinical trials for treatment of tumors, and various dosing regimes are given. Tumor reduction has been observed in several tumor types including renal carcinoma, colorectal cancer, lung carcinoid, medullary thyroid carcinomas and melanoma. It has also been found that aplidine has a role in inhibiting angiogenesis, complementing the anti-tumor activity.
摘要翻译: Aplidine在阶段(I)治疗肿瘤的临床试验中表现出相当大的希望,并给出了各种给药方案。 已经在几种肿瘤类型中观察到肿瘤减少,包括肾癌,结肠直肠癌,肺类癌,甲状腺髓样癌和黑素瘤。 还发现阿普立定在抑制血管发生中具有补充抗肿瘤活性的作用。
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公开(公告)号:US07507708B2
公开(公告)日:2009-03-24
申请号:US10531533
申请日:2003-10-20
摘要: The present invention is directed to new kahalalide antitumoral compounds, in particular to analogues of kahalalide F, useful as antitumoral, antiviral, antifungal agents and in the treatment of psoriasis.
摘要翻译: 本发明涉及新的卡伐拉定抗肿瘤化合物,特别是可用作抗肿瘤,抗病毒,抗真菌剂和用于治疗牛皮癣的卡拉拉肽F的类似物。
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公开(公告)号:US07381703B2
公开(公告)日:2008-06-03
申请号:US10548710
申请日:2004-03-12
申请人: Joseph R. Bertino , Daniel Medina , Glynn Thomas Faircloth , Constantine S. Mitsiades , Kenneth Anderson , Nicholas Mitsiades
发明人: Joseph R. Bertino , Daniel Medina , Glynn Thomas Faircloth , Constantine S. Mitsiades , Kenneth Anderson , Nicholas Mitsiades
CPC分类号: A61K38/15
摘要: Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.
摘要翻译: Aplidine和aplidine类似物用于制备治疗多发性骨髓瘤的药物。
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公开(公告)号:US20080076772A1
公开(公告)日:2008-03-27
申请号:US11576115
申请日:2005-09-28
IPC分类号: A61K31/4995 , A61P29/00
CPC分类号: A61K31/498
摘要: We have found anti-inflammatory activity in the ecteinascidin compounds. Such compounds have been widely described, and may have the following general formula (I): wherein: R5 is OH, alkoxy or alkanoyloxy; R6 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R12 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R16 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R17 is OH, alkoxy or alkanoyloxy; R18 is OH, alkoxy or alkanoyloxy; R21 is H, OH, CN or another nucleophilic group; and Ra is hydrogen and Rb is optionally substituted amino, or Ra with Rb form a carbonyl function ═O, or Ra, Rb and the carbon to which they are attached form a tetrahydroisoquinoline group.
摘要翻译: 我们已经发现了抗坏血酸蛋白化合物的抗炎活性。 已经广泛地描述了这些化合物,并且可以具有以下通式(I):其中:R 5是OH,烷氧基或烷酰氧基; R 6是氢,烷基,烯基,炔基或芳基; R 12是氢,烷基,烯基,炔基或芳基; R 16是氢,烷基,烯基,炔基或芳基; R 17是OH,烷氧基或烷酰氧基; R 18是OH,烷氧基或烷酰氧基; R 21是H,OH,CN或另一个亲核基团; 且R a a为氢,R b为任选取代的氨基,或R a为R b,形成羰基 官能团-O,或R a,R b和它们所连接的碳形成四氢异喹啉基团。
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公开(公告)号:US20120107417A1
公开(公告)日:2012-05-03
申请号:US13341262
申请日:2011-12-30
申请人: Naoto Takahashi , Steve Weitman , Maurizio D'Incalci , Glynn Thomas Faircloth , Rafaella Giavazzi , Andreas Gescher
发明人: Naoto Takahashi , Steve Weitman , Maurizio D'Incalci , Glynn Thomas Faircloth , Rafaella Giavazzi , Andreas Gescher
IPC分类号: A61K33/24 , A61P35/00 , A61K31/573 , A61K31/4995 , A61K31/704
CPC分类号: A61K31/495 , A61K45/06 , A61K31/00 , A61K2300/00
摘要: ET-743 is used in the preparation of a medicament for an effective treatment of a tumour by combination therapy employing ET-743 with another drug.
摘要翻译: ET-743用于通过使用ET-743与另一种药物的组合疗法来制备用于有效治疗肿瘤的药物。
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公开(公告)号:US20090324744A1
公开(公告)日:2009-12-31
申请号:US12552347
申请日:2009-09-02
申请人: Naoto Takahashi , Steve Weitman , Maurizio D'incalci , Glynn Thomas Faircloth , Rafaella Giavazzi , Andreas Gescher
发明人: Naoto Takahashi , Steve Weitman , Maurizio D'incalci , Glynn Thomas Faircloth , Rafaella Giavazzi , Andreas Gescher
IPC分类号: A61K33/24 , C07D513/22 , A61K31/4985 , A61K31/704 , A61K31/573
CPC分类号: A61K31/495 , A61K45/06 , A61K31/00 , A61K2300/00
摘要: ET-743 is used in the preparation of a medicament for an effective treatment of a tumour by combination therapy employing ET-743 with another drug.
摘要翻译: ET-743用于通过使用ET-743与另一种药物的组合疗法来制备用于有效治疗肿瘤的药物。
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公开(公告)号:US20090246168A1
公开(公告)日:2009-10-01
申请号:US12278559
申请日:2007-02-28
申请人: Glynn Thomas Faircloth , Pablo Manuel Aviles Marin , Doreen LePage , Jesus San Miguel Izquierdo , Atanasio Pandiella
发明人: Glynn Thomas Faircloth , Pablo Manuel Aviles Marin , Doreen LePage , Jesus San Miguel Izquierdo , Atanasio Pandiella
IPC分类号: A61K38/00 , A61K38/20 , A61K38/21 , A61K39/395 , A61P35/00
CPC分类号: A61K45/06 , A61K38/15 , A61K38/2013 , A61K38/212 , A61K2300/00
摘要: The present invention relates to combinations of aplidine or aplidine analogues with other antitumoral agents, and the use of these combinations in the treatment of cancer, in particular in the treatment of lung cancer, breast cancer, colon cancer, prostate cancer, renal cancer, melanoma, multiple myeloma, leukemia and lymphoma.
摘要翻译: 本发明涉及aplidine或aplidine类似物与其他抗肿瘤剂的组合,以及这些组合在治疗癌症中的用途,特别是在治疗肺癌,乳腺癌,结肠癌,前列腺癌,肾癌,黑素瘤中的用途 ,多发性骨髓瘤,白血病和淋巴瘤。
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公开(公告)号:US07473681B2
公开(公告)日:2009-01-06
申请号:US10399571
申请日:2001-10-31
IPC分类号: A61K38/00
CPC分类号: A61K9/0019 , A61K9/19 , A61K47/12 , A61K47/26
摘要: Formulations and uses of kahalalide F.
摘要翻译: 卡那利多F的制剂和用途
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