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13 条记录 (耗时 0.023 秒)

    APLIDINE TREATMENT OF CANCERS
    1.
    发明申请
    APLIDINE TREATMENT OF CANCERS 审中-公开
    癌症治疗

    公开(公告)号：US20090298752A1

    公开(公告)日：2009-12-03

    申请号：US12342478

    申请日：2008-12-23

    申请人： Glynn Thomas Faircloth ,  Luis Paz-Ares ,  Chris Twelves

    发明人： Glynn Thomas Faircloth ,  Luis Paz-Ares ,  Chris Twelves

    IPC分类号： A61K38/12 ,  A61P35/00

    CPC分类号： A61K31/205 ,  A61K38/15 ,  A61K2300/00

    摘要： Aplidine demonstrates considerable promise in phase (I) clinical trials for treatment of tumors, and various dosing regimes are given. Tumor reduction has been observed in several tumor types including renal carcinoma, colorectal cancer, lung carcinoid, medullary thyroid carcinomas and melanoma. It has also been found that aplidine has a role in inhibiting angiogenesis, complementing the anti-tumor activity.

    摘要翻译： Aplidine在阶段（I）治疗肿瘤的临床试验中表现出相当大的希望，并给出了各种给药方案。 已经在几种肿瘤类型中观察到肿瘤减少，包括肾癌，结肠直肠癌，肺类癌，甲状腺髓样癌和黑素瘤。 还发现阿普立定在抑制血管发生中具有补充抗肿瘤活性的作用。

    Anti-Inflammatory Agents
    8.
    发明申请
    Anti-Inflammatory Agents 审中-公开
    抗炎药

    公开(公告)号：US20080076772A1

    公开(公告)日：2008-03-27

    申请号：US11576115

    申请日：2005-09-28

    申请人： Paola Allavena ,  Maurizio D'Incalci ,  Glynn Thomas Faircloth

    发明人： Paola Allavena ,  Maurizio D'Incalci ,  Glynn Thomas Faircloth

    IPC分类号： A61K31/4995 ,  A61P29/00

    CPC分类号： A61K31/498

    摘要： We have found anti-inflammatory activity in the ecteinascidin compounds. Such compounds have been widely described, and may have the following general formula (I): wherein: R5 is OH, alkoxy or alkanoyloxy; R6 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R12 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R16 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R17 is OH, alkoxy or alkanoyloxy; R18 is OH, alkoxy or alkanoyloxy; R21 is H, OH, CN or another nucleophilic group; and Ra is hydrogen and Rb is optionally substituted amino, or Ra with Rb form a carbonyl function ═O, or Ra, Rb and the carbon to which they are attached form a tetrahydroisoquinoline group.

    摘要翻译： 我们已经发现了抗坏血酸蛋白化合物的抗炎活性。 已经广泛地描述了这些化合物，并且可以具有以下通式（I）：其中：R 5是OH，烷氧基或烷酰氧基; R 6是氢，烷基，烯基，炔基或芳基; R 12是氢，烷基，烯基，炔基或芳基; R 16是氢，烷基，烯基，炔基或芳基; R 17是OH，烷氧基或烷酰氧基; R 18是OH，烷氧基或烷酰氧基; R 21是H，OH，CN或另一个亲核基团; 且R a a为氢，R b为任选取代的氨基，或R a为R b，形成羰基 官能团-O，或R a，R b和它们所连接的碳形成四氢异喹啉基团。