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公开(公告)号：US07108867B2
公开(公告)日：2006-09-19
申请号：US10250868
申请日：2002-01-21
CPC分类号： A61K38/28 , A61K9/1688 , A61K31/167 , A61K31/575 , A61K31/58 , B01D11/0411 , Y10S977/773 , A61K2300/00
摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.
摘要翻译： 一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中具有随温度升高而降低的溶解度; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中 当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。 还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。
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公开(公告)号：US07829123B2
公开(公告)日：2010-11-09
申请号：US11521631
申请日：2006-09-15
CPC分类号： A61K38/28 , A61K9/1688 , A61K31/167 , A61K31/575 , A61K31/58 , B01D11/0411 , Y10S977/773 , A61K2300/00
摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.
摘要翻译： 一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中具有随温度升高而降低的溶解度; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中 当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。 还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。
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