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61 条记录 (耗时 0.022 秒)

    Process
    4.
    发明授权
    Process 失效
    处理

    公开(公告)号：US07829123B2

    公开(公告)日：2010-11-09

    申请号：US11521631

    申请日：2006-09-15

    申请人： Goran Eric Sundholm ,  Mustafa Demirbuker ,  Saeed Moshashaee

    发明人： Goran Eric Sundholm ,  Mustafa Demirbuker ,  Saeed Moshashaee

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/28 ,  B01J2/04 ,  B01J13/00

    CPC分类号： A61K38/28 ,  A61K9/1688 ,  A61K31/167 ,  A61K31/575 ,  A61K31/58 ,  B01D11/0411 ,  Y10S977/773 ,  A61K2300/00

    摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.

    摘要翻译： 一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中具有随温度升高而降低的溶解度; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中 当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。 还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。

    Process
    5.
    发明申请
    Process 失效
    处理

    公开(公告)号：US20070009604A1

    公开(公告)日：2007-01-11

    申请号：US11521631

    申请日：2006-09-15

    申请人： Goran Sundholm ,  Mustafa Demirbuker ,  Saeed Moshashaee

    发明人： Goran Sundholm ,  Mustafa Demirbuker ,  Saeed Moshashaee

    IPC分类号： A61K38/28 ,  A61K31/573 ,  B29B9/00 ,  A61K9/14

    CPC分类号： A61K38/28 ,  A61K9/1688 ,  A61K31/167 ,  A61K31/575 ,  A61K31/58 ,  B01D11/0411 ,  Y10S977/773 ,  A61K2300/00

    摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.

    摘要翻译： 一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中的溶解度随温度升高而降低; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中 当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。 还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。

    Method for producing particles
    6.
    发明申请
    Method for producing particles 审中-公开
    生产颗粒的方法

    公开(公告)号：US20060141110A1

    公开(公告)日：2006-06-29

    申请号：US10536038

    申请日：2003-11-21

    申请人： Jacques Fages ,  Jean-Jacques Letourneau ,  Philippe Gonus

    发明人： Jacques Fages ,  Jean-Jacques Letourneau ,  Philippe Gonus

    IPC分类号： A23L1/00

    CPC分类号： A23G1/36 ,  A23G1/0016 ,  A23G1/0046 ,  A23G1/047 ,  A23G1/18 ,  A23G3/0017 ,  A23G3/0231 ,  A23L3/361 ,  B01D1/18 ,  B01D11/0411 ,  C11B7/005

    摘要： The invention concerns a method for producing particles (20, 21) at least partly crystallized, under pressure, comprising reciprocal dissolving of at least one fluid under higher or slightly lower pressure than its critical pressure with at least one substance to be treated, in a dissolving zone (2), followed by rapid depressurization with at least one depressurizing means (12) downstream of said dissolving zone (2) so as to collect said particles (21), at least partly crystallized, in the collecting zone (3) located downstream of said depressurizing means (12), said substance to be treated comprising the butterfat. Said method is characterized in that it further consists in collecting particles (20) at least partly crystallized in the dissolving zone (2). The invention also concerns a device (1) for implementing said method.

    摘要翻译： 本发明涉及一种用于生产在压力下至少部分结晶的颗粒（20,21）的方法，该方法包括在至少一种待处理物质的压力下与至少一种待处理物质相比在至少一种流体的压力下略微溶解至少一种流体， 溶解区（2），然后用至少一个减压装置（12）在所述溶解区（2）的下游进行快速减压，以便收集所述颗粒（21）至少部分结晶化，位于收集区（3）中 在所述减压装置（12）的下游，所述待处理物质包括乳脂。 所述方法的特征在于它还包括收集在溶解区（2）中至少部分结晶的颗粒（20）。 本发明还涉及用于实现所述方法的装置（1）。

    Method and apparatus for the formation of particles
    7.
    发明申请
    Method and apparatus for the formation of particles 审中-公开
    用于形成颗粒的方法和装置

    公开(公告)号：US20060073087A1

    公开(公告)日：2006-04-06

    申请号：US11157116

    申请日：2005-06-20

    申请人： Mazen Hanna ,  Peter York

    发明人： Mazen Hanna ,  Peter York

    IPC分类号： C22B3/00

    CPC分类号： A61K9/1688 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0411 ,  B01D11/0488 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  Y02P20/544

    摘要： The invention provides a method for forming particles of a substance, by co-introducing into a particle formation vessel, in which the temperature and pressure are controlled, of a supercritical fluid; a solution or suspension of the substance in a first vehicle; and a second vehicle which is both substantially miscible with the first vehicle and substantially soluble in the supercritical fluid, in such a way that dispersion of the solution or suspension and the second vehicle, and extraction of the vehicles, occur substantially simultaneously and substantially immediately on introduction of the fluids into the vessel, by the action of the supercritical fluid. Preferably the solution/suspension of the substance is introduced separately from the second vehicle, in such a way that contact between the solution/suspension and the second vehicle occurs either substantially simultaneously with, or immediately before, their dispersion by the supercritical fluid and extraction of the vehicles by the supercritical fluid. The method allows a high degree of control over the size, shape, crystalline form and other physico-chemical properties of the particulate product. The invention also provides apparatus for carrying out such a method, using a coaxial nozzle to introduce the fluids into the particle formation vessel, and a particulate product made using the method or the apparatus.

    摘要翻译： 本发明提供了通过将超临界流体共同引入其中控制温度和压力的颗粒形成容器中来形成物质颗粒的方法; 该物质在第一种载体中的溶液或悬浮液; 以及第二种载体，其基本上与第一种载体混溶并且基本上可溶于超临界流体，使得溶液或悬浮液和第二载体的分散和载体的萃取基本上同时且基本上立即出现在 通过超临界流体的作用将流体引入容器。 优选地，物质的溶液/悬浮液与第二载体分开引入，使得溶液/悬浮液和第二载体之间的接触基本上与超临界流体分散或同时或之前由超临界流体分散出来， 车辆由超临界流体。 该方法允许高度控制颗粒产品的尺寸，形状，结晶形式和其他物理化学性质。 本发明还提供了一种使用同轴喷嘴将流体引入颗粒形成容器中的这种方法的装置，以及使用该方法或装置制成的颗粒状产品。

    Method and apparatus for enhanced size reduction of particles using supercritical fluid liquefaction of materials
    8.
    发明授权
    Method and apparatus for enhanced size reduction of particles using supercritical fluid liquefaction of materials 有权
    使用超临界流体物质液化来增强颗粒尺寸减小的方法和装置

    公开(公告)号：US06986846B2

    公开(公告)日：2006-01-17

    申请号：US10932559

    申请日：2004-09-02

    申请人： Boris Y. Shekunov ,  Pratibhash Chattopadhyay ,  Jeffrey S. Seitzinger

    发明人： Boris Y. Shekunov ,  Pratibhash Chattopadhyay ,  Jeffrey S. Seitzinger

    IPC分类号： B01D11/02 ,  A61K9/14

    CPC分类号： B01J2/02 ,  A61K9/1647 ,  A61K9/1694 ,  B01D11/0411

    摘要： The present invention provides a method and an apparatus for forming particles using supercritical fluid. The method includes the steps of mixing a load material with a first flow of a supercritical fluid in a first mixing chamber having a primary mixing device disposed therein to form a melt, transferring the melt from the first mixing chamber to a second mixing chamber having a secondary mixing device disposed therein, mixing the melt with a second flow of the supercritical fluid in the second mixing chamber to form a lower viscosity melt, expanding the lower viscosity melt across a pressure drop into an expansion chamber that is at a pressure below the critical pressure of the supercritical fluid to convert the supercritical fluid to a gas and thereby precipitate the load material in the form of particles.

    摘要翻译： 本发明提供使用超临界流体形成颗粒的方法和装置。 该方法包括以下步骤：在第一混合室中混合负载材料与超临界流体的第一流，其中设置有初级混合装置以形成熔体，将熔体从第一混合室转移到具有 二次混合装置设置在其中，将熔体与第二混合室中的超临界流体的第二流混合，以形成较低粘度的熔体，将较低粘度的熔体在压降范围内膨胀到膨胀室内，该膨胀室的压力低于临界值 超临界流体的压力将超临界流体转化为气体，从而使负载材料以颗粒的形式沉淀。

    Method and apparatus for the formation of particles
    9.
    发明授权
    Method and apparatus for the formation of particles 有权
    用于形成颗粒的方法和装置

    公开(公告)号：US06440337B1

    公开(公告)日：2002-08-27

    申请号：US09380025

    申请日：1999-12-16

    申请人： Mazen Hanna ,  Peter York

    发明人： Mazen Hanna ,  Peter York

    IPC分类号： B29B900

    CPC分类号： B01D11/0407 ,  A61K9/1688 ,  B01D11/0403 ,  B01D11/0411 ,  B01D11/0488 ,  B01J2/04

    摘要： The invention provides a method and apparatus for forming particles of a substance, comprising (a) introducing into a particle formation chamber, the temperature and pressure in which are controlled, a first supercritical fluid (SCF) and a solution or suspension of the substance in a vehicle; (b) simultaneously introducing an impinging flow of a second supercritical fluid (SCF), at an angle to, and directed at, the direction of flow of the first supercritical fluid, so as to increase the amount of kinetic energy transferred to the solution or suspension; and (c) using either or both of the first and the second supercritical fluids to disperse the solution or suspension, and to extract the vehicle from it, substantially simultaneously and substantially immediately on introduction of the fluids into the particle chamber.

    摘要翻译： 本发明提供了一种用于形成物质颗粒的方法和装置，包括（a）将第一超临界流体（SCF）和该物质的溶液或悬浮液引入颗粒形成室中，其中控制的温度和压力 一辆车; （b）同时引入与所述第一超临界流体的流动方向成角度并且指向所述第一超临界流体的流动方向的第二超临界流体（SCF）的冲击流，以增加传递到所述溶液的动能的量或 悬挂; 和（c）使用第一和第二超临界流体中的任一种或两者来分散溶液或悬浮液，并在将流体引入颗粒室的同时基本上立即从其中提取载体。