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公开(公告)号:US06573367B1
公开(公告)日:2003-06-03
申请号:US09869606
申请日:2001-07-02
IPC分类号: C07H100
摘要: The invention relates to novel compounds from the class of the macrolide antibiotic oleandomycin of the general formula (I) wherein R1 has the individual meaning of —CH2CH3 group, of a fragment of the formula (II), together with R2 has the meaning of a fragment of the formula (III) or together with R4 has the meaning of a fragment of the formula (IV) or a fragment of the formula (V) R2 together with R3 has the meaning of a ketone or together with R1 has the meaning of a fragment of the formula (III), R3 has the individual meaning of OH group or together with R2 has the meaning of a ketone, R4 has the individual meaning of a methyl group, or together with R1 has the meaning of a fragment of the formula (IV) or of a fragment of the formula (V), R5 has the individual meaning of hydrogen or a benzyloxycarbonyl group, R6 has the individual meaning of hydrogen, a methyl group or a benzyloxycarbonyl group, to intermediates for the preparation thereof, to a process for preparing them as well as to pharmaceutically acceptable addition salts thereof with inorganic or organic acids.
摘要翻译: 本发明涉及通式(I)的大环内酯类抗生素素多霉素类别的新化合物,其中R 1具有-CH 2 CH 3基团的单独含义,式(II)的片段,以及R2具有片段的含义 式(III)或与R4一起具有式(Ⅳ)的片段或式(Ⅴ)的片段的含义R 2与R 3一起具有酮的含义或与R 1一起具有以下含义: 式(III)的片段,R3具有OH基团的单独含义或与R2一起具有酮的含义,R4具有甲基的单独含义,或与R 1一起具有式 (Ⅳ)或式(Ⅴ)的片段,R5具有氢或苄氧基羰基的独立含义,R 6具有氢,甲基或苄氧基羰基的单个含义,用于制备其中间体, 一个准备它们以及pha的过程 其药学上可接受的加成盐与无机或有机酸。