公开(公告)号：US06582692B1

公开(公告)日：2003-06-24

申请号：US09715858

申请日：2000-11-17

申请人： Gregory Podsakoff ,  Gordon Watson

发明人： Gregory Podsakoff ,  Gordon Watson

IPC分类号： A01N6300

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N9/2434 ,  C12N2750/14143 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/42 ,  C12N2830/85 ,  C12N2840/44 ,  C12Y302/01031

摘要： AAV expression vectors and recombinant virions produced using these vectors, which include genes coding for enzymes defective or missing in lysosomal storage disorders, are described. These recombinant AAV virions are useful in the treatment of a variety of lysosomal storage disorders and the methods described herein provide for long-term, sustained expression of the defective or missing enzyme.

公开(公告)号：US20060104954A1

公开(公告)日：2006-05-18

申请号：US11329941

申请日：2006-01-11

申请人： Gregory Podsakoff ,  Gordon Watson ,  Linda Couto ,  Bin Yang

发明人： Gregory Podsakoff ,  Gordon Watson ,  Linda Couto ,  Bin Yang

IPC分类号： A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N9/2434 ,  C12N2750/14143 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/42 ,  C12N2830/85 ,  C12N2840/44 ,  C12Y302/01031

摘要： AAV expression vectors and recombinant virions produced using these vectors, which include genes coding for enzymes defective or missing in lysosomal storage disorders, are described. These recombinant AAV virions are useful in the treatment of a variety of lysosomal storage disorders and the methods described herein provide for long-term, sustained expression of the defective or missing enzyme.

公开(公告)号：US4709492A

公开(公告)日：1987-12-01

申请号：US884001

申请日：1986-07-10

申请人： Gordon Watson

发明人： Gordon Watson

IPC分类号： E01H5/02 ,  E01H5/06 ,  E02F3/815 ,  E01H5/04

CPC分类号： E01H5/066 ,  E01H5/02 ,  E01H5/061 ,  E02F3/8152

摘要： A device for back scraping snow, earth, or other like substances which generally includes a truck having a concave snowplow blade mounted on its front. The blade has shoes provided on its backside, wedge shaped hinged connections mounted on the shoes, and a flat blade mounted pivotably on said wedge brackets. When the flat blade is brought in contact with snow to be scraped and the snowplow blade is moved in a backwardly direction, the snow to be scraped is moved by the flat blade.

摘要翻译： 用于后刮刮雪，土或其他类似物质的装置，其通常包括安装在其前面的具有凹面积雪刮刀的卡车。 刀片具有设置在其后侧的鞋，安装在鞋上的楔形铰接连接件和可枢转地安装在所述楔形支架上的平坦刀片。 当扁平叶片与被刮的雪接触并且刮风刮刀沿向后的方向移动时，被刮削的雪被平的叶片移动。