公开(公告)号：US06413776B1

公开(公告)日：2002-07-02

申请号：US09097239

申请日：1998-06-12

申请人： Ronald Vogels ,  Abraham Bout ,  Helmuth H. G. van Es ,  Govert Shouten

发明人： Ronald Vogels ,  Abraham Bout ,  Helmuth H. G. van Es ,  Govert Shouten

IPC分类号： C12N510

CPC分类号： C12N15/1034 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/42

摘要： Novel adenovirus vectors and methods for their use are provided to determine the function of the product(s) of one or more sample nucleic acids. The sample nucleic acids are synthetic oligonucleotides, DNA, or cDNA and encode polypeptides, antisense nucleic acids or GSEs. The sample nucleic acids are expressed in a host by recombinant adenovirus vectors to alter at least one phenotype of the host. The altered phenotype(s) is identified as a means to assign a biological function to the product(s) encoded by the sample nucleic acid(s).

摘要翻译： 提供新型腺病毒载体及其使用方法以确定一种或多种样品核酸的产物的功能。 样品核酸是合成寡核苷酸，DNA或cDNA，并编码多肽，反义核酸或GSE。 样品核酸通过重组腺病毒载体在宿主中表达以改变宿主的至少一种表型。 改变的表型被鉴定为将样品核酸编码的产物赋予生物学功能的手段。