专利检索 ap:"Graham Elgin Jones" 第 1 页

1.

发明授权
Tricyclic PI3K inhibitor compounds and methods of use 有权
标题翻译：三环PI3K抑制剂化合物及其使用方法

公开(公告)号：US08883799B2

公开(公告)日：2014-11-11

申请号：US13326524

申请日：2011-12-15

申请人： Jennafer Dotson , Robert Andrew Heald , Timothy Heffron , Graham Elgin Jones , Sussie Lerche Krintel , Neville James McLean , Chudi Ndubaku , Alan G. Olivero , Laurent Salphati , Lan Wang , BinQing Wei

发明人： Jennafer Dotson , Robert Andrew Heald , Timothy Heffron , Graham Elgin Jones , Sussie Lerche Krintel , Neville James McLean , Chudi Ndubaku , Alan G. Olivero , Laurent Salphati , Lan Wang , BinQing Wei

IPC分类号： C07D471/04 , C07D471/22 , C07D487/04 , C07D413/00 , C07D265/00 , C07D498/00 , A61K31/535 , C07D498/14 , C07D491/14 , C07D495/14 , C07D487/14

CPC分类号： C07D498/22 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K39/3955 , A61K2039/505 , C07D471/14 , C07D471/22 , C07D487/14 , C07D491/14 , C07D491/147 , C07D495/14 , C07D498/14 , C07D498/20 , C07K16/22 , C07K2317/24

摘要： Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

摘要翻译： 描述了具有抗癌活性，抗炎活性或免疫调节特性，更具体地与PI3激酶调节或抑制活性的式I的三环PI3k抑制剂化合物。描述了使用式I的三环PI3K抑制剂化合物用于体外，原位和体内诊断或治疗哺乳动物细胞，生物体或相关病理条件的方法。式I化合物包括立体异构体，几何异构体，互变异构体及其药学上可接受的盐。虚线表示可选的双键，至少一条虚线是双键。取代基如所述。

2.

发明申请
TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE 有权
标题翻译： TRICYCLIC PI3K抑制剂化合物及其使用方法

公开(公告)号：US20120171199A1

公开(公告)日：2012-07-05

申请号：US13326524

申请日：2011-12-15

申请人： Jennafer Dotson , Robert Andrew Heald , Timothy Heffron , Graham Elgin Jones , Sussie Lerche Krintel , Neville James McLean , Chudi Ndubaku , Alan G. Olivero , Laurent Salphati , Lan Wang , BinQing Wei

发明人： Jennafer Dotson , Robert Andrew Heald , Timothy Heffron , Graham Elgin Jones , Sussie Lerche Krintel , Neville James McLean , Chudi Ndubaku , Alan G. Olivero , Laurent Salphati , Lan Wang , BinQing Wei

IPC分类号： A61K31/5383 , C07D491/147 , C07D498/14 , C07D487/14 , C07D498/22 , A61K31/5386 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P37/02 , A61P25/00 , A61P9/00 , A61P1/16 , A61P31/12 , A61P7/00 , A61P3/10 , A61P37/04 , A61P35/02 , C07D471/14 , C07D495/14 , A61K39/395

CPC分类号： C07D498/22 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K39/3955 , A61K2039/505 , C07D471/14 , C07D471/22 , C07D487/14 , C07D491/14 , C07D491/147 , C07D495/14 , C07D498/14 , C07D498/20 , C07K16/22 , C07K2317/24

摘要： Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

摘要翻译： 描述了具有抗癌活性，抗炎活性或免疫调节特性，更具体地与PI3激酶调节或抑制活性的式I的三环PI3k抑制剂化合物。描述了使用式I的三环PI3K抑制剂化合物用于体外，原位和体内诊断或治疗哺乳动物细胞，生物体或相关病理条件的方法。式I化合物包括立体异构体，几何异构体，互变异构体及其药学上可接受的盐。虚线表示可选的双键，至少一条虚线是双键。取代基如所述。

3.

发明申请
Pyrrolo-Quinoxalinone Derivatives as Antibacterials 失效
标题翻译：吡咯 - 喹喔啉酮衍生物作为抗菌剂

公开(公告)号：US20090062265A1

公开(公告)日：2009-03-05

申请号：US12295749

申请日：2007-03-29

申请人： Graham Elgin Jones , Timothy James Miles , Neil David Pearson

发明人： Graham Elgin Jones , Timothy James Miles , Neil David Pearson

IPC分类号： A61K31/542 , C07D487/04 , A61K31/4985 , A61K31/5383 , C07D498/04 , C07D513/04

CPC分类号： C07D487/06

摘要： Tricyclic nitrogen containing compounds and their use as antibacterials.

摘要翻译： 三环含氮化合物及其作为抗菌剂的用途。

4.

发明授权
Nitrogen-containing bicyclic heterocycles for use as antibacterials 失效
标题翻译：含氮双环杂环用作抗菌剂

公开(公告)号：US07141564B2

公开(公告)日：2006-11-28

申请号：US10478154

申请日：2002-05-24

申请人： Gerald Brooks , David Thomas Davies , Graham Elgin Jones , Roger Edward Markwell , Neil David Pearson

发明人： Gerald Brooks , David Thomas Davies , Graham Elgin Jones , Roger Edward Markwell , Neil David Pearson

IPC分类号： A61K31/542 , A61K31/4375 , C07D513/04 , C07D471/04 , A61P31/04

CPC分类号： C07D401/12 , C07D405/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D513/04

摘要： Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.

摘要翻译： 环己烷和环己烯衍生物及其药学上可接受的衍生物可用于治疗哺乳动物，特别是人的细菌感染的方法。

5.

发明授权
Indole derivatives as 5-HT receptor antagonist 失效
标题翻译：吲哚衍生物作为5-HT受体拮抗剂

公开(公告)号：US06235758B1

公开(公告)日：2001-05-22

申请号：US09359606

申请日：1999-07-23

申请人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones

发明人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones

IPC分类号： C07D40104

CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14

摘要： A compound of formula (I) or a salt thereof: wherein: P1 is pyridiyl; P2 is phenyl; A is a bond or a chain of 1 to 5 atoms optionally substituted by C1-6 alkyl; R1 and R2 groups are each independently hydrogen, C1-6alkyl optionally substituted by NR12R13, C2-6alkenyl, C2-6alkynyl, cyano, halogen, CF3, NR12R13, CHO, OCF3, COR14, CH2OR14 or OR14 where R12, R13 and R14 are independently hydrogen or C1-6alkyl; n and m are independently 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R4 is a group of formula (i): in which: R6 and R7 are independently hydrogen, C1-6 alkyl optionally substituted by one or more fluorine atoms, C1-6alkylthio, C1-6alkoxy or halogen.

摘要翻译： 式（I）化合物或其盐：其中：P1为吡啶基; P2为苯基; A为任选被C 1-6烷基取代的1至5个原子的键或链; R 1和R 2基团各自独立地为氢任选被NR 12 R 13，C 2-6烯基，C 2-6炔基，氰基，卤素，CF 3，NR 12 R 13，CHO，OCF 3，COR 14，CH 2 OR 14或OR 14取代的C 1-6烷基，其中R 12，R 13和R 14独立地为氢或C 1-6烷基; n和 m独立地是0,1或2; R 3是氢或C 1-6烷基; R 4是式（ⅰ）的基团：其中：R 6和R 7独立地是氢，被一个或多个氟原子任意取代的C 1-6烷基，C 1-6烷硫基，C 1-6烷氧基或卤素。

6.

发明授权
Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones 有权
标题翻译： N-乙基喹诺酮和N-乙基喹诺酮类的衍生物和类似物

公开(公告)号：US08071592B2

公开(公告)日：2011-12-06

申请号：US12374389

申请日：2007-07-18

申请人： Lluis Ballell , David Barros , Gerald Brooks , Julia Castro Pichel , Steven Dabbs , Robert A Daines , David Thomas Davies , Jose Maria Fiandor Roman , Israil Pendrak , Modesto J Remuiñan Blanco , Jason Anthony Rossi , Ilaria Giordano , Alan Joseph Hennessy , James B Hoffman , Graham Elgin Jones , Timothy James Miles , Neil David Pearson , Lihua(lily) Zhang

发明人： Lluis Ballell , David Barros , Gerald Brooks , Julia Castro Pichel , Steven Dabbs , Robert A Daines , David Thomas Davies , Jose Maria Fiandor Roman , Israil Pendrak , Modesto J Remuiñan Blanco , Jason Anthony Rossi , Ilaria Giordano , Alan Joseph Hennessy , James B Hoffman , Graham Elgin Jones , Timothy James Miles , Neil David Pearson , Lihua(lily) Zhang

IPC分类号： C07D491/04 , C07D497/04 , C07D498/04 , A61K31/5383 , A61K31/519

CPC分类号： C07D491/04 , A61K31/519 , A61K31/538 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D497/04 , C07D498/04 , C07D513/04 , C07D519/00

摘要： Bicyclic nitrogen containing compounds and their use as antibacterials.

摘要翻译： 双环含氮化合物及其作为抗菌剂的用途。

7.

发明授权
Heterocyclic compounds, their preparation and their use as antibacterials 失效
标题翻译：杂环化合物，它们的制备及其作为抗菌剂的用途

公开(公告)号：US07732460B2

公开(公告)日：2010-06-08

申请号：US12158397

申请日：2006-12-15

申请人： Nathalie Cailleau , David Thomas Davies , Alan Joseph Hennessy , Graham Elgin Jones , Timothy James Miles , Neil David Pearson

发明人： Nathalie Cailleau , David Thomas Davies , Alan Joseph Hennessy , Graham Elgin Jones , Timothy James Miles , Neil David Pearson

IPC分类号： C07D471/16 , C07D493/04 , A61K31/4375

CPC分类号： C07D471/16 , C07D519/00

摘要： Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.

摘要翻译： 式（I）的三环氮化合物及其作为抗菌剂的用途。

8.

发明授权
Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity 失效
标题翻译：氨基哌啶喹啉及其具有抗菌活性的azaisosteric类似物

公开(公告)号：US07534793B2

公开(公告)日：2009-05-19

申请号：US11219148

申请日：2005-09-02

申请人： David Thomas Davies , Graham Elgin Jones , Andrew P Lightfoot , Roger Edward Markwell , Neil David Pearson

发明人： David Thomas Davies , Graham Elgin Jones , Andrew P Lightfoot , Roger Edward Markwell , Neil David Pearson

IPC分类号： A61K31/4709 , C07D215/16

CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04

摘要： Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man

摘要翻译： 氨基哌啶衍生物及其药学上可接受的衍生物，其可用于哺乳动物，特别是人的细菌感染治疗方法