公开(公告)号：US20100049236A1

公开(公告)日：2010-02-25

申请号：US12543528

申请日：2009-08-19

申请人： Chandan K. Sen ,  Cameron Rink ,  Sashwati Roy ,  Greg Christoforidis

发明人： Chandan K. Sen ,  Cameron Rink ,  Sashwati Roy ,  Greg Christoforidis

IPC分类号： A61M29/00 ,  A61B5/00

CPC分类号： A61K49/0008 ,  G01N33/5088 ,  G09B23/36

摘要： An agent for treating strokes in humans is tested in a non-human subject by selecting an agent for testing and by preparing a selected non-human subject. The preparation includes: inducing a stroke event by advancing a microwire through the arterial system of the subject to a selected intracranial target position, inserting a microcatheter along the microwire and delivering an embolic device to the target position, occluding the artery at the target position by deploying the embolic device, verifying the occlusion and repositioning the embolic device if needed. After a predetermined occlusion interval, reperfusion of the subject is simulated by removing the embolic device and commencing therapy with the selected agent. At appropriate intervals, the effect of the conducted course of therapy is assessed non-invasively until terminal evaluation. In particular aspects, the method involves occluding the middle cerebral artery through an access achieved via the basilar artery.

摘要翻译： 通过选择用于测试的试剂和通过制备选定的非人受试者，在非人受试者中测试用于治疗人类中风的药剂。 该制剂包括：通过将微线穿过受试者的动脉系统推进到选定的颅内靶位置来诱导卒中事件，沿着微丝插入微导管并将栓塞装置输送到目标位置，通过在目标位置闭塞动脉 部署栓塞装置，验证堵塞并根据需要重新定位栓塞装置。 在预定的闭塞间隔之后，通过去除栓塞装置并用所选择的药剂开始治疗来模拟受试者的再灌注。 在适当的时间间隔内，进行治疗过程的效果是非侵入性的，直到终点评估。 在特定方面，该方法涉及通过经由基底动脉获得的通路阻塞中脑动脉。