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    METHODS AND COMPOSITIONS FOR THE TOPICAL OXYGENATION OF HYPOXIC TISSUE
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR THE TOPICAL OXYGENATION OF HYPOXIC TISSUE 审中-公开
    HYPOXIC组织局部氧化的方法和组合

    公开(公告)号：US20100035798A1

    公开(公告)日：2010-02-11

    申请号：US12441523

    申请日：2007-09-17

    申请人： Chandan K. Sen ,  Sashwati Roy ,  Savita Khanna

    发明人： Chandan K. Sen ,  Sashwati Roy ,  Savita Khanna

    IPC分类号： A61K38/16 ,  A61P17/02 ,  A61M37/00

    CPC分类号： A61K38/42

    摘要： The invention provides methods, delivery devices, and compositions for topically oxygenating hypoxic tissue with a hemoglobin-based oxygen earner (HBOC), such as Oxyglobin (Oxyb) in order to promote wound healing and/or reducing hypoxia in post-harvest transplant tissue. The invention can be used, among other things, to stimulate angiogenesis and blood flow at a wound site, reduce wound dilation, and promote wound contraction, thereby increasing the overall rate of wound healing. The invention can also be used, among other things, to reduce oxidative stress in pre-implantation donor organ tissue, as well as stimulate the proliferation of granulation tissue, vessel growth, and promote epithelial healing in transplant tissue once it has been implanted.

    摘要翻译： 本发明提供了使用基于血红蛋白的氧气收集器（HBOC），例如氧球蛋白（Oxyb）来局部氧合缺氧组织的方法，递送装置和组合物，以便促进伤口愈合和/或在收获后移植组织中减少缺氧。 本发明可以用于刺激伤口部位的血管生成和血流，减少伤口扩张，促进伤口收缩，从而提高伤口愈合的总体速率。 除了别的以外，本发明还可以用于减少植入前供体器官组织中的氧化应激，以及刺激造粒组织的增殖，血管生长，并且一旦移植组织植入就能促进移植组织的上皮愈合。

    Protective and therapeutic uses for tocotrienols
    2.
    发明申请
    Protective and therapeutic uses for tocotrienols 审中-公开
    生育三烯酚的保护和治疗用途

    公开(公告)号：US20050228041A1

    公开(公告)日：2005-10-13

    申请号：US10914339

    申请日：2004-08-09

    申请人： Chadan Sen ,  Sashwati Roy ,  Savita Khanna

    发明人： Chadan Sen ,  Sashwati Roy ,  Savita Khanna

    IPC分类号： A61K20060101 ,  A61K31/355

    CPC分类号： A61K31/355

    摘要： Therapeutic and prophylactic agents comprising tocotrienols, and methods of using the same are provided for the treatment of and the prevention of the onset of stroke and other disorders and diseases associated with elevated glutamate levels, and the effects of lipoxygenases such as the enzyme 12-lipoxygenase.

    摘要翻译： 提供包括生育三烯酚的治疗和预防剂及其使用方法用于治疗和预防与升高的谷氨酸水平相关的中风和其他疾病和疾病的发作，以及脂氧合酶如12-脂肪氧合酶 。

    Lipoic acid analogs
    4.
    发明授权
    Lipoic acid analogs 失效
    硫辛酸类似物

    公开(公告)号：US6090842A

    公开(公告)日：2000-07-18

    申请号：US37782

    申请日：1998-03-10

    申请人： Lester Packer ,  Oren Tirosh ,  Chandan K. Sen ,  Sashwati Roy

    发明人： Lester Packer ,  Oren Tirosh ,  Chandan K. Sen ,  Sashwati Roy

    IPC分类号： A61K8/00 ,  A61K8/49 ,  A61K31/385 ,  A61P39/06 ,  A61P43/00 ,  A61Q19/00 ,  C07D339/04 ,  A61K31/415 ,  A61K31/44 ,  C07D339/02 ,  C07D409/00

    CPC分类号： C07D339/04

    摘要： A compound is provided having the formula I: ##STR1## wherein R.sup.1 and R.sup.2 independently denote a methylene, ethylene or unbranched or branched C.sub.3-16 alkylene, alkenylene or alkynylene group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in the unbranched or branched C.sub.3-16 alkylene, alkenylene or alkynylene group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom,R.sup.3 and R.sup.4(i) independently denote(a) hydrogen,(b) a methyl, ethyl, vinyl or unbranched or branched C.sub.3-16 alkyl, alkenyl or alkynyl group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in said unbranched or branched C.sub.3-16 alkyl, alkenyl or alkynyl group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom,(c) a cycloalkyl, alkylcycloalkyl, alkenylcycloalkyl or alkynylcycloalkyl group having 5 to 16 carbon atoms which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, or(d) an aryl, alkaryl, aralkyl, alkenylaryl, aralkenyl, alkynylaryl or aralkynyl group having 6 to 16 carbon atoms which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, or(iii) jointly with the nitrogen atom form a cyclic or aromatic amine which is unsubstituted or substituted with one or more alkyl, alkenyl, alkynyl, halogen, hydroxyl or amine groups,X denotes O, S, --NH-- or --NR.sup.5 --, andR.sup.5 denotes methyl, ethyl, or unbranched or branched C.sub.3-16 alkyl, or a pharmaceutically acceptable salt thereof, wherein the compound is in equilibrium at physiological pH with a protonated form thereof.Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species are also provided.

    摘要翻译： 提供具有式I的化合物：其中R 1和R 2独立地表示未被取代或被一个或多个卤素，羟基或胺基取代的亚甲基，亚乙基或无支链或支链C 3-16亚烷基，亚烯基或亚炔基，其中在 可以用氧原子代替其碳主链中的非支链或支链C 3-16亚烷基，亚烯基或亚炔基和内亚烷基碳原子，R 3和R 4独立地表示（a）氢，（b）甲基， 乙基，乙烯基或未经取代或被一个或多个卤素，羟基或胺基取代的无支链或支链C 3-6-16烷基，链烯基或炔基，其中在所述未分支或支链的C 3-6-16烷基，烯基或炔基中， 其碳主链中的碳原子可以被氧原子取代，（c）具有5至16个碳原子的环烷基，烷基环烷基，烯基环烷基或炔基环烷基，其是未取代的或取代的 具有一个或多个卤素，羟基或胺基团，或（d）具有6至16个碳原子的芳基，烷芳基，芳烷基，烯基芳基，芳烯基，炔基芳基或芳炔基，其未被取代或被一个或多个卤素，羟基或 胺基团，或（iii）与氮原子一起形成未被取代或被一个或多个烷基，烯基，炔基，卤素，羟基或胺基取代的环状或芳族胺，X表示O，S，-NH-或 -NR5-和R5表示甲基，乙基或无支链或支链C 3-6 - 烷基，或其药学上可接受的盐，其中所述化合物在生理pH处于其质子化形式的平衡状态。 还提供了制备化合物的方法，包括该化合物的组合物和涉及活性氧的条件的处理方法。

    Lipoic acid analogs
    6.
    发明授权
    Lipoic acid analogs 失效
    硫辛酸类似物

    公开(公告)号：US06387945B2

    公开(公告)日：2002-05-14

    申请号：US09852074

    申请日：2001-05-09

    申请人： Lester Packer ,  Oren Tirosh ,  Chandan K. Sen ,  Sashwati Roy

    发明人： Lester Packer ,  Oren Tirosh ,  Chandan K. Sen ,  Sashwati Roy

    IPC分类号： A61K31385

    CPC分类号： C07D339/02

    摘要： A compound is provided having the formula I: wherein the variables are defined in the specification. Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species are also provided.

    摘要翻译： 提供具有式I的化合物：其中变量在说明书中定义。 还提供了制备化合物的方法，包括该化合物的组合物和涉及活性氧的条件的处理方法。

    METHOD FOR TESTING AN AGENT FOR STROKES IN HUMANS WITH A NON-HUMAN STROKE MODEL
    8.
    发明申请
    METHOD FOR TESTING AN AGENT FOR STROKES IN HUMANS WITH A NON-HUMAN STROKE MODEL 审中-公开
    用非人类模型测试人类肌体的方法

    公开(公告)号：US20100049236A1

    公开(公告)日：2010-02-25

    申请号：US12543528

    申请日：2009-08-19

    申请人： Chandan K. Sen ,  Cameron Rink ,  Sashwati Roy ,  Greg Christoforidis

    发明人： Chandan K. Sen ,  Cameron Rink ,  Sashwati Roy ,  Greg Christoforidis

    IPC分类号： A61M29/00 ,  A61B5/00

    CPC分类号： A61K49/0008 ,  G01N33/5088 ,  G09B23/36

    摘要： An agent for treating strokes in humans is tested in a non-human subject by selecting an agent for testing and by preparing a selected non-human subject. The preparation includes: inducing a stroke event by advancing a microwire through the arterial system of the subject to a selected intracranial target position, inserting a microcatheter along the microwire and delivering an embolic device to the target position, occluding the artery at the target position by deploying the embolic device, verifying the occlusion and repositioning the embolic device if needed. After a predetermined occlusion interval, reperfusion of the subject is simulated by removing the embolic device and commencing therapy with the selected agent. At appropriate intervals, the effect of the conducted course of therapy is assessed non-invasively until terminal evaluation. In particular aspects, the method involves occluding the middle cerebral artery through an access achieved via the basilar artery.

    摘要翻译： 通过选择用于测试的试剂和通过制备选定的非人受试者，在非人受试者中测试用于治疗人类中风的药剂。 该制剂包括：通过将微线穿过受试者的动脉系统推进到选定的颅内靶位置来诱导卒中事件，沿着微丝插入微导管并将栓塞装置输送到目标位置，通过在目标位置闭塞动脉 部署栓塞装置，验证堵塞并根据需要重新定位栓塞装置。 在预定的闭塞间隔之后，通过去除栓塞装置并用所选择的药剂开始治疗来模拟受试者的再灌注。 在适当的时间间隔内，进行治疗过程的效果是非侵入性的，直到终点评估。 在特定方面，该方法涉及通过经由基底动脉获得的通路阻塞中脑动脉。

    Lipoic acid analogs
    9.
    发明授权
    Lipoic acid analogs 有权
    硫辛酸类似物

    公开(公告)号：US06235772B1

    公开(公告)日：2001-05-22

    申请号：US09546497

    申请日：2000-04-11

    申请人： Lester Packer ,  Oren Tirosh ,  Chandan K. Sen ,  Sashwati Roy

    发明人： Lester Packer ,  Oren Tirosh ,  Chandan K. Sen ,  Sashwati Roy

    IPC分类号： A61K31385

    CPC分类号： C07D339/04

    摘要： A compound is provided having the formula I: as defined in the specification. Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species are also provided.

    摘要翻译： 提供具有式I的化合物：如说明书中所定义。 还提供了制备化合物的方法，包括该化合物的组合物和涉及活性氧的条件的处理方法。