公开(公告)号：US20060024657A1

公开(公告)日：2006-02-02

申请号：US11234461

申请日：2005-09-23

申请人： Greg Fahy ,  Jun Wu

发明人： Greg Fahy ,  Jun Wu

IPC分类号： A01N1/00 ,  A01N1/02

CPC分类号： C09K3/18 ,  A01N1/02 ,  A01N1/0221 ,  C09K5/20

摘要： Polyglycerol, lactose, and a combination of polyglycerol and lactose are effective at preserving cells, tissues, and organs from damage due to hypothermic, ischemic, or other metabolic impairment, and a mixture of polyglycerol plus lactose is particularly useful for the hypothermic storage of cells, tissues, and organs. The mixture of polyglycerol and lactose can be further improved by the addition of chondroitin sulfate, chlorpromazine, calcium, citrate, glutathione, adenine, glucose, magnesium, and a pH buffer.

公开(公告)号：US06616858B2

公开(公告)日：2003-09-09

申请号：US09726857

申请日：2000-11-30

申请人： Greg Fahy ,  Brian Wowk

发明人： Greg Fahy ,  Brian Wowk

IPC分类号： C09K318

CPC分类号： A01N1/0221 ,  A01N1/02 ,  C09K3/18 ,  C09K5/20

摘要： Linear polymers of glycerol can prevent or delay ice nucleation in a variety of contexts. Polyglycerol can also be employed in combination with other ice control agents, such as polyvinyl alcohol/polyvinyl acetate copolymers and antifreeze proteins, to provide antinucleation effects that are superior to those of either polyglycerol or the co-antinucleator alone. Polyglycerol has a number of advantageous physical and toxicological properties, such as extreme water solubility, non-toxicity to human beings, non-toxicity to animal tissues and organs in vitro even at extreme concentrations, minimal foaming tendency, minimal retention on hydrophobic surfaces, and stability in solution without the need for periodic heating to reactivate its antinucleation properties.

摘要翻译： 甘油的线性聚合物可以防止或延迟各种情况下的冰核化。 聚甘油也可以与其它冰控制剂（例如聚乙烯醇/聚乙酸乙烯酯共聚物和防冻蛋白）组合使用，以提供优于单独的聚甘油或共聚单核苷酸的抗核苷酸化作用。 聚甘油具有许多有利的物理和毒理学性质，例如极端的水溶性，对人体无毒性，甚至在极端浓度下体内对动物组织和器官无毒性，最小发泡倾向，疏水性表面上的最小保留性，以及 溶液的稳定性，不需要定期加热来重新激活其反核化性能。