公开(公告)号：US07148065B2

公开(公告)日：2006-12-12

申请号：US10923324

申请日：2004-08-20

申请人： Gregory I. Bohach

发明人： Gregory I. Bohach

IPC分类号： C12N15/00

CPC分类号： C07K14/31

摘要： Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced toxicity compared to the corresponding unmodified native toxin. The native pyrogenic toxins are typically modified by deletions within the disulfide loop region to produce modified enterotoxins having 100-fold or greater decrease in toxicity.

摘要翻译： 提供了在二硫化物环区域中修饰的热原毒素，例如葡萄球菌肠毒素。 修饰的毒素保留有用的生物学特性，但与相应的未经修饰的天然毒素相比具有显着降低的毒性。 天然热原毒素通常通过在二硫化物环区域内的缺失来修饰，以产生具有100倍或更大毒性降低的改良的肠毒素。

公开(公告)号：US06872394B1

公开(公告)日：2005-03-29

申请号：US09555115

申请日：1998-12-01

申请人： Gregory I. Bohach

发明人： Gregory I. Bohach

IPC分类号： C07K14/31 ,  A61K39/00 ,  A61K39/38 ,  C07K1/00 ,  C07K14/00

CPC分类号： C07K14/31

摘要： Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced toxicity compared to the corresponding unmodified native toxin. The native pyrogenic toxins are typically modified by deletions within the disulfide loop region to produce modified enterotoxins having 100-fold or greater decrease in toxicity.