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公开(公告)号:US20060030536A1
公开(公告)日:2006-02-09
申请号:US11102911
申请日:2005-04-08
申请人: Hua Yu , Richard Jove , Jin Cheng , Guilian Niu , Said Sebti
发明人: Hua Yu , Richard Jove , Jin Cheng , Guilian Niu , Said Sebti
IPC分类号: A61K48/00 , A61K39/395
CPC分类号: C12N15/1135 , A61K31/282 , A61K31/7064 , A61K39/395 , A61K45/06 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2320/31 , A61K2300/00
摘要: Compositions and methods for treating cancer and proliferative angiopathies are provided. A composition can include an inhibitor of the Jak2/Stat3 signaling pathway and an inhibitor of the PI3k/Akt signaling pathway. In certain cases, the two inhibitors are capable of acting synergistically as compared to either inhibitor alone.
摘要翻译: 提供了治疗癌症和增殖性血管病的组合物和方法。 组合物可以包括Jak2 / Stat3信号通路的抑制剂和PI3k / Akt信号通路的抑制剂。 在某些情况下,与单独的抑制剂相比,两种抑制剂能够协同作用。