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1.发明授权(2,5-dioxoimidazolidin-i-yl)-n-hydroxy-acetamides as metalloproteinase inhibitors 失效（2,5-二氧代咪唑烷-1-基）-n-羟基 - 乙酰胺作为金属蛋白酶抑制剂公开(公告)号：US08338471B2
公开(公告)日：2012-12-25
申请号：US13222883
申请日：2011-08-31
申请人： Hans Wallberg , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
发明人： Hans Wallberg , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
IPC分类号： A61K31/4166 , C07D233/02
CPC分类号： C07D233/78 , C07D233/76
摘要： The invention provides compounds of the formula (I) wherein the variables are as defined in the specification.The compounds of the invention are inhibitors of metalloproteinase MMP-12 and are among other things useful for the treatment of obstructive airway diseases, such as chronic obstructive pulmonary disease (COPD).
摘要翻译： 本发明提供式（I）化合物，其中变量如说明书中所定义。 本发明的化合物是金属蛋白酶MMP-12的抑制剂，也可用于治疗阻塞性气道疾病，如慢性阻塞性肺疾病（COPD）。
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2.发明申请(2,5-DIOXOIMIDAZOLIDIN-I-YL)-N-HYDROXY-ACETAMIDES AS METALLOPROTEINASE INHIBITORS 失效（2,5-DIOXOIMIDAZOLIDIN-I-YL）-N-羟基 - 乙酰胺作为金属蛋白酶抑制剂公开(公告)号：US20120015994A1
公开(公告)日：2012-01-19
申请号：US13222883
申请日：2011-08-31
申请人： Hans WALLBERG , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
发明人： Hans WALLBERG , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
IPC分类号： A61K31/4166 , A61P11/06 , A61P11/00 , C07D233/72
CPC分类号： C07D233/78 , C07D233/76
摘要： The invention provides compounds of the formula (I) wherein the variables are as defined in the specification. The compounds of the invention are inhibitors of metalloproteinase MMP-12 and are among other things useful for the treatment of obstructive airway diseases, such as chronic obstructive pulmonary disease (COPD).
摘要翻译： 本发明提供式（I）化合物，其中变量如说明书中所定义。 本发明的化合物是金属蛋白酶MMP-12的抑制剂，也可用于治疗阻塞性气道疾病，如慢性阻塞性肺疾病（COPD）。
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3.发明授权(2,5-dioxoimidazolidin-1-yl)-N-hydroxy-acetamides as metalloproteinase inhibitors 失效（2,5-二氧代咪唑烷-1-基）-N-羟基 - 乙酰胺作为金属蛋白酶抑制剂公开(公告)号：US08022092B2
公开(公告)日：2011-09-20
申请号：US12097192
申请日：2006-12-13
申请人： Hans Wallberg , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
发明人： Hans Wallberg , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
IPC分类号： C07D233/64 , A61K31/4164 , A61K31/4166
CPC分类号： C07D233/78 , C07D233/76
摘要： The invention provides compounds of the formula (I) wherein the variables are as defined in the specification. The compounds of the invention are inhibitors of metalloproteinase MMP-12 and are among other things useful for the treatment of obstructive airway diseases, such as chronic obstructive pulmonary disease (COPD).
摘要翻译： 本发明提供式（I）化合物，其中变量如说明书中所定义。 本发明的化合物是金属蛋白酶MMP-12的抑制剂，也可用于治疗阻塞性气道疾病，如慢性阻塞性肺疾病（COPD）。
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4.发明申请(2,5-DIOXOIMIDAZOLIDIN-I-YL)-N-HYDROXY-ACETAMIDES AS METALLOPROTEINASE INHIBITORS 失效（2,5-DIOXOIMIDAZOLIDIN-I-YL）-N-羟基 - 乙酰胺作为金属蛋白酶抑制剂公开(公告)号：US20090215846A1
公开(公告)日：2009-08-27
申请号：US12097192
申请日：2006-12-13
申请人： Hans Wallberg , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
发明人： Hans Wallberg , Ming-Hua Xu , Guo-Qiang Lin , Xin-Sheng Lei , Piaoyang Sun , Kevin Parkes , Tony Johnson , Bertil Samuelsson
IPC分类号： A61K31/4174 , C07D233/74 , A61P11/00
CPC分类号： C07D233/78 , C07D233/76
摘要： The invention provides compounds of the formula (I) wherein the variables are as defined in the specification. The compounds of the invention are inhibitors of metalloproteinase MMP-12 and are among other things useful for the treatment of obstructive airway diseases, such as chronic obstructive pulmonary disease (COPD).
摘要翻译： 本发明提供式（I）化合物，其中变量如说明书中所定义。 本发明的化合物是金属蛋白酶MMP-12的抑制剂，也可用于治疗阻塞性气道疾病，如慢性阻塞性肺疾病（COPD）。
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