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公开(公告)号：US07479480B2
公开(公告)日：2009-01-20
申请号：US12121317
申请日：2008-05-15
申请人： H. Bryan Brewer, Jr.
发明人： H. Bryan Brewer, Jr.
IPC分类号： C07K14/00
CPC分类号： A61K51/08 , C07K14/775
摘要： Disclosed herein are peptides with domains that promote lipid efflux from cells and optionally possess at least one anti-inflammatory domain or a domain that stimulates LCAT activity. Provided herein are methods of using the peptides to treat or inhibit diseases including dyslipidemic disorders, stroke and myocardial infarction. Also provided are methods of detecting plaque in vessels using the labeled peptides of the present invention.
摘要翻译： 本文公开了具有促进脂质从细胞流出并且任选地具有至少一个抗炎结构域或刺激LCAT活性的结构域的结构域的肽。 本文提供使用肽来治疗或抑制疾病的方法，包括血脂异常，中风和心肌梗死。 还提供了使用本发明的标记肽检测血管中斑块的方法。
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2.发明授权Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US07361739B2
公开(公告)日：2008-04-22
申请号：US10996570
申请日：2004-11-23
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
IPC分类号： C07K1/00
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。
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3.发明授权公开(公告)号：US08048015B2
公开(公告)日：2011-11-01
申请号：US12054162
申请日：2008-03-24
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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4.发明授权Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US08030281B2
公开(公告)日：2011-10-04
申请号：US12042881
申请日：2008-03-05
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。
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5.发明授权公开(公告)号：US07393826B2
公开(公告)日：2008-07-01
申请号：US11260861
申请日：2005-10-26
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
IPC分类号： A01N37/18
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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6.发明授权Use of lecithin-cholesterol acyltransferase (LCAT) to reduce accumulation of cholesterol 有权使用卵磷脂 - 胆固醇酰基转移酶（LCAT）来减少胆固醇的积累公开(公告)号：US06635614B1
公开(公告)日：2003-10-21
申请号：US09068386
申请日：1999-11-22
IPC分类号： A61K3800
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/107 , A01K2267/03 , A01K2267/0375 , A61K38/00 , A61K48/00 , C12N9/1029 , C12N2799/021
摘要： This invention provides methods for treating atherosclerosis in a mammalian subject by increasing the activity of LCAT in the serum of the subject to a level effective to decrease the accumulation of cholesterol in the subject. Pharmaceutical dosage forms containing LCAT also are provided.
摘要翻译： 本发明提供了通过将受试者血清中LCAT的活性提高到有效降低受试者胆固醇积累的水平来治疗哺乳动物受试者的动脉粥样硬化的方法。 还提供了包含LCAT的药物剂型。
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7.发明申请Methods and Apparatus for Creating Particle Derivatives of HDL with Reduced Lipid Content 有权用于创建具有降低的脂质含量的HDL的颗粒衍生物的方法和装置公开(公告)号：US20110318423A1
公开(公告)日：2011-12-29
申请号：US13222287
申请日：2011-08-31
申请人： Marc Bellotti , H. Bryan Brewer, JR. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, JR. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。
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公开(公告)号：US20080255051A1
公开(公告)日：2008-10-16
申请号：US12121317
申请日：2008-05-15
申请人： H. Bryan Brewer, Jr.
发明人： H. Bryan Brewer, Jr.
CPC分类号： A61K51/08 , C07K14/775
摘要： Disclosed herein are peptides with domains that promote lipid efflux from cells and optionally possess at least one anti-inflammatory domain or a domain that stimulates LCAT activity. Provided herein are methods of using the peptides to treat or inhibit diseases including dyslipidemic disorders, stroke and myocardial infarction. Also provided are methods of detecting plaque in vessels using the labeled peptides of the present invention.
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9.发明授权公开(公告)号：US07375191B2
公开(公告)日：2008-05-20
申请号：US10796691
申请日：2004-03-08
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
IPC分类号： C07K1/00
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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10.发明授权Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US08637460B2
公开(公告)日：2014-01-28
申请号：US13601131
申请日：2012-08-31
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。
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