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公开(公告)号：US10080654B2
公开(公告)日：2018-09-25
申请号：US15277807
申请日：2016-09-27
发明人： Paul C. Ho
CPC分类号： A61F2/2418 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B2017/00703 , A61F2/2433 , A61F2250/0059 , A61F2250/006
摘要： A delivery system and method for percutaneous aortic valve (PAV) replacement and apparatus used therein. A temporary aortic valve including a reversibly expandable occluding medium surrounds a central catheter mechanism. The temporary valve is positioned within the ascending aorta, just above and downstream from the coronary ostia. The occluding medium is configured such that, when fully expanded against the aortic wall, gaps are left that promote continuous coronary perfusion during the cardiac cycle. The temporary valve substitutes for the function of the native aortic valve during its replacement. The native aortic valve is next dilated, and then ablated through deployment of low profile, elongated, sequentially delivered stents. The stent(s) displace the native tissues and remain within the aortic annulus to receive and provide a structure for retaining the PAV. The PAV is delivered, positioned and deployed within the stent(s) at the aortic annulus with precision and relative ease.
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公开(公告)号：US20160346079A1
公开(公告)日：2016-12-01
申请号：US15083768
申请日：2016-03-29
发明人： PAUL C. HO
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2427 , A61F2/2454 , A61F2/2466 , A61F2230/0008 , A61F2230/0067 , A61F2250/0059
摘要： Methods and apparatuses for regulating aortic regurgitation are provided. A catheter shaft is advanced through vasculature so that a flexible occluding membrane coupled to the catheter shaft is positioned within the aorta, typically the ascending aorta above the Sinus of Valsalva and coronary ostia. Blood flow in the aorta causes the flexible occluding membrane to alternate between an expanded occluding configuration while in diastole and a collapsed lesser occluding configuration is systole. There flexible occluding membrane thereby acts as a temporary aortic valve. The flexible occluding membrane is generally conical in shape, with the tip of the cone disposed closer to the aorta than the proximal rim. In diastole, blood flow expands the flexible occluding membrane so that the proximal rim apposes the inner wall of the aorta. The flexible occluding membrane will have one or more openings to allow perfusion of the coronary arteries in diastole.
摘要翻译： 提供了调节主动脉瓣反流的方法和装置。 导管轴通过脉管系统前进，使得联接到导管轴的柔性闭塞膜定位在主动脉内，通常是Valsalva窦和冠状动脉口上升的主动脉。 主动脉中的血液流动导致柔性闭塞膜在舒张期间在膨胀的闭塞构型之间交替，并且收缩的较少闭塞构型是收缩。 因此，柔性闭塞膜可用作临时主动脉瓣。 柔性闭塞膜通常是圆锥形的，锥体的尖端比近侧边缘更靠近主动脉。 在舒张期，血流膨胀柔性闭塞膜，使得近侧边缘适应主动脉的内壁。 柔性闭塞膜将具有一个或多个开口以允许冠状动脉灌注舒张期。
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公开(公告)号：US11253356B2
公开(公告)日：2022-02-22
申请号：US16104616
申请日：2018-08-17
发明人： Paul C. Ho
摘要： A delivery system and method for percutaneous aortic valve (PAV) replacement and apparatus used therein. A temporary aortic valve including a reversibly expandable occluder surrounds a central catheter mechanism. The temporary valve is positioned within the ascending aorta, just above and downstream from the coronary ostia. The occluder is configured such that, when fully expanded against the aortic wall, gaps are left that promote continuous coronary perfusion during the cardiac cycle. The temporary valve substitutes for the function of the native aortic valve during its replacement. The native aortic valve is next dilated, and then ablated through deployment of low profile, elongated, sequentially delivered stents. The stent(s) displace the native tissues and remain within the aortic annulus to receive and provide a structure for retaining the PAV. The PAV is delivered, positioned and deployed within the stent(s) at the aortic annulus with precision and relative ease.
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公开(公告)号：US20140142692A1
公开(公告)日：2014-05-22
申请号：US14154890
申请日：2014-01-14
发明人： Paul C. HO
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B2017/00703 , A61F2/2433 , A61F2250/0059 , A61F2250/006
摘要： A delivery system and method for percutaneous aortic valve (PAV) replacement and apparatus used therein. A temporary aortic valve including a reversibly expandable occluding means surrounds a central catheter mechanism. The temporary valve is positioned within the ascending aorta, just above and downstream from the coronary ostia. The occluding means is configured such that, when fully expanded against the aortic wall, gaps are left that promote continuous coronary perfusion during the cardiac cycle. The temporary valve substitutes for the function of the native aortic valve during its replacement. The native aortic valve is next dilated, and then ablated through deployment of low profile, elongated, sequentially delivered stents. The stent(s) displace the native tissues and remain within the aortic annulus to receive and provide a structure for retaining the PAV. The PAV is delivered, positioned and deployed within the stent(s) at the aortic annulus with precision and relative ease.
摘要翻译： 用于经皮主动脉瓣（PAV）置换的输送系统和方法及其中使用的装置。 包括可逆膨胀的闭塞装置的临时主动脉瓣围绕中心导管机构。 临时瓣膜位于升主动脉的正上方和下游。 闭塞装置被构造成使得当完全相对于主动脉壁膨胀时，留下在心脏周期期间促进连续冠状动脉灌注的间隙。 临时阀代替天然主动脉瓣的功能。 然后将原发性主动脉瓣扩张，然后通过部署低调，细长的依次递送的支架进行消融。 支架置换天然组织并保留在主动脉环内以接收并提供用于保持PAV的结构。 PAV在精确和相对容易的情况下被传送，定位和部署在主动脉环的支架内。
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公开(公告)号：US10751181B2
公开(公告)日：2020-08-25
申请号：US15821056
申请日：2017-11-22
发明人： Paul C. Ho
IPC分类号： A61F2/24
摘要： Methods and apparatuses for regulating aortic regurgitation are provided. A catheter shaft is advanced through vasculature so that a flexible occluding membrane coupled to the catheter shaft is positioned within the aorta, typically the ascending aorta above the Sinus of Valsalva and coronary ostia. Blood flow in the aorta causes the flexible occluding membrane to alternate between an expanded occluding configuration while in diastole and a collapsed lesser occluding configuration is systole. The flexible occluding membrane thereby acts as a temporary aortic valve. The flexible occluding membrane is generally conical in shape, with the tip of the cone disposed closer to the aorta than the proximal rim. In diastole, blood flow expands the flexible occluding membrane so that the proximal rim apposes the inner wall of the aorta. The flexible occluding membrane will have one or more openings to allow perfusion of the coronary arteries in diastole.
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公开(公告)号：US20190069902A1
公开(公告)日：2019-03-07
申请号：US16129719
申请日：2018-09-12
发明人： Paul C. Ho
摘要： Methods and systems for regulating aortic regurgitation during aortic valve replacement or repair procedures utilize a temporary aortic valve (TAV) catheter and a controller. The temporary aortic valve catheter has an expandable occlusion device which can partially occlude the aortic lumen during ventricular diastole with a lesser occlusion during ventricular systole. Exemplary balloon structures include multiple, independently inflatable balloons which are inflated in synchrony with the cardiac cycle by the controller. By controlling aortic regurgitation, the repair or replacement protocols can be conducted with less interference from blood flow.
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公开(公告)号：US20140200658A1
公开(公告)日：2014-07-17
申请号：US14155060
申请日：2014-01-14
发明人： Paul C. HO
IPC分类号： A61F2/24
CPC分类号： A61F2/2433 , A61B17/12022 , A61B17/1204 , A61B17/12136 , A61B2017/22055 , A61B2017/22067 , A61F2/2418 , A61F2250/0059
摘要： A catheter adapted for placement in the ascending aorta comprises a central catheter mechanism and a balloon structure or other occluding structure at its distal end. The catheter may be placed over the aortic arch such that the occluding structure is placed in the ascending aorta just above the Sinus of Valsalva and coronary ostia. Once in place, the occluding structure is inflated to control blood flow through the aorta during aortic valve ablation and replacement protocols.
摘要翻译： 适于放置在升主动脉中的导管在其远端包括中心导管机构和球囊结构或其它阻塞结构。 导管可以放置在主动脉弓上，使得闭塞结构置于正好位于Valsalva和冠状动脉口窦上方的升主动脉。 一旦到位，闭塞结构被膨胀以在主动脉瓣消融和置换方案期间控制通过主动脉的血流。
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公开(公告)号：US10098644B2
公开(公告)日：2018-10-16
申请号：US15058999
申请日：2016-03-02
发明人： Paul C. Ho
摘要： Methods and systems for regulating aortic regurgitation during aortic valve replacement or repair procedures utilize a temporary aortic valve (TAV) catheter and a controller. The temporary aortic valve catheter has an expandable occlusion device which can partially occlude the aortic lumen during ventricular diastole with a lesser occlusion during ventricular systole. Exemplary balloon structures include multiple, independently inflatable balloons which are inflated in synchrony with the cardiac cycle by the controller. By controlling aortic regurgitation, the repair or replacement protocols can be conducted with less interference from blood flow.
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公开(公告)号：US20180092742A1
公开(公告)日：2018-04-05
申请号：US15821056
申请日：2017-11-22
发明人： Paul C. HO
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2427 , A61F2/2454 , A61F2/2466 , A61F2230/0008 , A61F2230/0067 , A61F2250/0059
摘要： Methods and apparatuses for regulating aortic regurgitation are provided. A catheter shaft is advanced through vasculature so that a flexible occluding membrane coupled to the catheter shaft is positioned within the aorta, typically the ascending aorta above the Sinus of Valsalva and coronary ostia. Blood flow in the aorta causes the flexible occluding membrane to alternate between an expanded occluding configuration while in diastole and a collapsed lesser occluding configuration is systole. There flexible occluding membrane thereby acts as a temporary aortic valve. The flexible occluding membrane is generally conical in shape, with the tip of the cone disposed closer to the aorta than the proximal rim. In diastole, blood flow expands the flexible occluding membrane so that the proximal rim apposes the inner wall of the aorta. The flexible occluding membrane will have one or more openings to allow perfusion of the coronary arteries in diastole.
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公开(公告)号：US09855143B2
公开(公告)日：2018-01-02
申请号：US15083768
申请日：2016-03-29
发明人： Paul C. Ho
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2427 , A61F2/2454 , A61F2/2466 , A61F2230/0008 , A61F2230/0067 , A61F2250/0059
摘要： Methods and apparatuses for regulating aortic regurgitation are provided. A catheter shaft is advanced through vasculature so that a flexible occluding membrane coupled to the catheter shaft is positioned within the aorta, typically the ascending aorta above the Sinus of Valsalva and coronary ostia. Blood flow in the aorta causes the flexible occluding membrane to alternate between an expanded occluding configuration while in diastole and a collapsed lesser occluding configuration is systole. There flexible occluding membrane thereby acts as a temporary aortic valve. The flexible occluding membrane is generally conical in shape, with the tip of the cone disposed closer to the aorta than the proximal rim. In diastole, blood flow expands the flexible occluding membrane so that the proximal rim apposes the inner wall of the aorta. The flexible occluding membrane will have one or more openings to allow perfusion of the coronary arteries in diastole.
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