公开(公告)号：US06984397B2

公开(公告)日：2006-01-10

申请号：US10636731

申请日：2003-08-08

申请人： Jiro Fujisaki ,  Hajime Konno ,  Akihiro Kasai ,  Kazumi Ohtomo

发明人： Jiro Fujisaki ,  Hajime Konno ,  Akihiro Kasai ,  Kazumi Ohtomo

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K31/407 ,  A61K31/436 ,  A61K31/7042

摘要： The present invention provides a pipecolic acid derivative-containing liposome preparation having has an excellent rapid action capable of coping with an emergent situation such as cerebral infarction.A liposome preparation characterized by comprising, as an active ingredient, a pipecolic acid derivative of the ingredient described in the present specification or a pharmaceutically acceptable salt thereof entrapped into liposomes, wherein lecithin is mainly used as the liposome-forming lipid, said liposome preparation containing no cholesterol as a stabilizer.

摘要翻译： 本发明提供具有能够应对脑梗塞等紧急情况的优异的快速作用的含哌啶酸衍生物的脂质体制剂。 一种脂质体制剂，其特征在于包含作为活性成分的本说明书中描述的成分的哌可酸衍生物或其包埋在脂质体中的药学上可接受的盐，其中卵磷脂主要用作形成脂质体的脂质，所述脂质体制剂含有 没有胆固醇作为稳定剂。

公开(公告)号：US06979461B1

公开(公告)日：2005-12-27

申请号：US10089084

申请日：2000-10-03

申请人： Kazumi Ohtomo ,  Hajime Konno ,  Akihiro Kasai

发明人： Kazumi Ohtomo ,  Hajime Konno ,  Akihiro Kasai

IPC分类号： A61K9/127 ,  A61K31/4353 ,  A61K31/436 ,  A61K47/24

CPC分类号： A61K9/1277 ,  A61K31/436

摘要： An object of the present invention is to provide a method for producing a liposome preparation having excellent rapid action and excellent redispersion into aqueous medium. The present invention provides a method for producing a liposome preparation by vacuum drying wherein liposome condensed solution, which is obtained by removing solvent from liposome solution, is subjected to vacuum drying without freezing while bubbling the condensed solution or after the condensed solution is bubbled.

摘要翻译： 本发明的目的是提供一种制备具有优异的快速作用和优异的再分散在水性介质中的脂质体制剂的方法。 本发明提供一种通过真空干燥生产脂质体制剂的方法，其中通过从脂质体溶液中除去溶剂获得的脂质体浓缩溶液在鼓泡冷凝溶液时或冷凝溶液鼓泡后进行真空干燥而不冷冻。