公开(公告)号：US06984397B2

公开(公告)日：2006-01-10

申请号：US10636731

申请日：2003-08-08

申请人： Jiro Fujisaki ,  Hajime Konno ,  Akihiro Kasai ,  Kazumi Ohtomo

发明人： Jiro Fujisaki ,  Hajime Konno ,  Akihiro Kasai ,  Kazumi Ohtomo

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K31/407 ,  A61K31/436 ,  A61K31/7042

摘要： The present invention provides a pipecolic acid derivative-containing liposome preparation having has an excellent rapid action capable of coping with an emergent situation such as cerebral infarction.A liposome preparation characterized by comprising, as an active ingredient, a pipecolic acid derivative of the ingredient described in the present specification or a pharmaceutically acceptable salt thereof entrapped into liposomes, wherein lecithin is mainly used as the liposome-forming lipid, said liposome preparation containing no cholesterol as a stabilizer.

摘要翻译： 本发明提供具有能够应对脑梗塞等紧急情况的优异的快速作用的含哌啶酸衍生物的脂质体制剂。 一种脂质体制剂，其特征在于包含作为活性成分的本说明书中描述的成分的哌可酸衍生物或其包埋在脂质体中的药学上可接受的盐，其中卵磷脂主要用作形成脂质体的脂质，所述脂质体制剂含有 没有胆固醇作为稳定剂。

公开(公告)号：US06979461B1

公开(公告)日：2005-12-27

申请号：US10089084

申请日：2000-10-03

申请人： Kazumi Ohtomo ,  Hajime Konno ,  Akihiro Kasai

发明人： Kazumi Ohtomo ,  Hajime Konno ,  Akihiro Kasai

IPC分类号： A61K9/127 ,  A61K31/4353 ,  A61K31/436 ,  A61K47/24

CPC分类号： A61K9/1277 ,  A61K31/436

摘要： An object of the present invention is to provide a method for producing a liposome preparation having excellent rapid action and excellent redispersion into aqueous medium. The present invention provides a method for producing a liposome preparation by vacuum drying wherein liposome condensed solution, which is obtained by removing solvent from liposome solution, is subjected to vacuum drying without freezing while bubbling the condensed solution or after the condensed solution is bubbled.

摘要翻译： 本发明的目的是提供一种制备具有优异的快速作用和优异的再分散在水性介质中的脂质体制剂的方法。 本发明提供一种通过真空干燥生产脂质体制剂的方法，其中通过从脂质体溶液中除去溶剂获得的脂质体浓缩溶液在鼓泡冷凝溶液时或冷凝溶液鼓泡后进行真空干燥而不冷冻。

公开(公告)号：US07112565B2

公开(公告)日：2006-09-26

申请号：US10772281

申请日：2004-02-06

申请人： Seiji Sawai ,  Akihiro Kasai ,  Kazumi Ohtomo

发明人： Seiji Sawai ,  Akihiro Kasai ,  Kazumi Ohtomo

IPC分类号： A61K38/00 ,  A61K38/12

CPC分类号： A61K38/12 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26

摘要： A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula (I): wherein R1 is a hydrogen atom or an acyl group and R2 and R3 are, the same or different, a hydrogen atom or a hydroxyl group, or a salt thereof and the stabilizer.

摘要翻译： 一种冻干形式的稳定化药物组合物，其包含：由通式（I）表示的环状多肽化合物：其中R 1是氢原子或酰基，R 2， 和R 3相同或不同，为氢原子或羟基，或其盐和稳定剂。

公开(公告)号：US06774104B1

公开(公告)日：2004-08-10

申请号：US09786125

申请日：2001-03-01

申请人： Seiji Sawai ,  Akihiro Kasai ,  Kazumi Otomo

发明人： Seiji Sawai ,  Akihiro Kasai ,  Kazumi Otomo

IPC分类号： A61K3800

CPC分类号： A61K38/12 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26

摘要： A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula (I): wherein R1 is a hydrogen atom or an acyl group and R2 and R3 are, the same or different, a hydrogen atom or a hydroxyl group, or a salt thereof and the stabilizer.

摘要翻译： 一种冻干形式的稳定化药物组合物，其包含：由通式（I）表示的环状多肽化合物：其中R 1为氢原子或酰基，R 2和R 3为相同或 不同的氢原子或羟基，或其盐和稳定剂。

公开(公告)号：US20100249413A1

公开(公告)日：2010-09-30

申请号：US12377461

申请日：2007-08-24

申请人： Makoto Murai ,  Yuichi Yonemochi ,  Kohsuke Shakushiro ,  Akihiro Kasai

发明人： Makoto Murai ,  Yuichi Yonemochi ,  Kohsuke Shakushiro ,  Akihiro Kasai

IPC分类号： C07D403/06

CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K31/497 ,  A61K47/12 ,  A61K47/20 ,  A61K47/22

摘要： [Problem] A stable liquid-form pharmaceutical composition wherein the decomposition with time is prevented and a stabilization method thereof is provided, for providing a liquid-form pharmaceutical composition of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium or a pharmaceutically acceptable salt thereof to a clinical field.[Means for Solution] Related are a stable pharmaceutical composition of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium or a pharmaceutically acceptable salt thereof, containing one kind or two or more kinds selected from the group consisting of carbazochrome sodium sulfonate and derivatives thereof, vitamin C's, butylhydroxylanisol, vitamin E's, Vitamin P's, gallic acid, propyl gallate, alpha-thioglycerine and cysteine hydrochloride, as well as a lyophilized product thereof and a stabilizing method thereof.

摘要翻译： [问题]为了提供1-（2-甲氧基乙基）-2-甲基-4,9-二甲酸的液体形式的药物组合物，其中防止了随时间的分解及其稳定方法的稳定的液体形式的药物组合物， 二氧代-3-（吡嗪-2-基甲基）-4,9-二氢-1H-萘并[2,3-d]咪唑-3-鎓或其药学上可接受的盐。 [解决方案]相关的是1-（2-甲氧基乙基）-2-甲基-4,9-二氧代-3-（吡嗪-2-基甲基）-4,9-二氢-1H-萘并[ 2,3-d]咪唑-3-鎓或其药学上可接受的盐，其包含选自咔唑类磺酸钠及其衍生物，维生素C，丁基羟基苯甲醚，维生素E，维生素P的一种或两种以上， 没食子酸，没食子酸丙酯，α-硫代甘油和半胱氨酸盐酸盐，以及其冻干产物及其稳定方法。

公开(公告)号：US5905282A

公开(公告)日：1999-05-18

申请号：US856997

申请日：1997-05-15

申请人： Masaaki Sato ,  Mitsuru Inoue ,  Yasuharu Yamada ,  Akihiro Kasai ,  Hideyuki Harada ,  Hirofumi Yoshihara

发明人： Masaaki Sato ,  Mitsuru Inoue ,  Yasuharu Yamada ,  Akihiro Kasai ,  Hideyuki Harada ,  Hirofumi Yoshihara

IPC分类号： H01L29/74 ,  H01L23/495 ,  H01L27/02 ,  H01L27/06 ,  H01L29/747 ,  H01L29/861 ,  H01L29/87 ,  H02H9/04 ,  H02M1/00 ,  H03K19/003 ,  H01L29/792 ,  H01L23/62

CPC分类号： H01L23/49562 ,  H01L24/05 ,  H01L27/0259 ,  H01L29/87 ,  H01L2224/05572 ,  H01L2224/06181 ,  H01L2924/12036 ,  H01L2924/1301

摘要： A multi-terminal surge protection device able to absorb surges of either polarity between lines and between a line and ground, in which the difference in operating time between the device elements connected to lines is reduced. A plurality of unipolar surge protection device elements are used which only operate to absorb surges of a specific polarity, and do not exhibit a reverse withstand characteristic upon application of a reverse-polarity voltage. One element is connected to a first line and another element to a second line, while a different element is connected to ground. A semiconductor substrate and second electrode are used that are common to all elements. To prevent lateral interference between elements, at least the element connected to ground is isolated from the line elements.

摘要翻译： 一种多端子浪涌保护装置，其能够吸收线路之间以及线路与地线之间的极性的浪涌，其中连接到线路的器件元件之间的操作时间差减小。 使用多个单极浪涌保护器件元件，其仅用于吸收特定极性的浪涌，并且在施加反极性电压时不表现出反向耐受特性。 一个元件连接到第一线，另一个元件连接到第二线，而不同的元件连接到地。 使用对所有元件是共同的半导体衬底和第二电极。 为了防止元件之间的横向干涉，至少连接到地面的元件与线路元件隔离。

公开(公告)号：US07034780B2

公开(公告)日：2006-04-25

申请号：US10329462

申请日：2002-12-27

申请人： Satoshi Fujita ,  Akihiro Kasai

发明人： Satoshi Fujita ,  Akihiro Kasai

IPC分类号： G09G3/28

CPC分类号： G09G5/006 ,  G09G3/296 ,  G09G2360/16

摘要： A plasma display device is provided which is capable of preventing image disturbance and imposition of excessive loads even when resolution is switched. A vertical frequency counter counts vertical sync signals using system clocks and a vertical frequency comparator checks whether or not the value obtained from the counting matches up with a vertical frequency decoded value. A line number counter counts vertical sync signals using horizontal sync signals and a line number comparator checks whether or not the value obtained from the counting matches up with a line number decoded value. A dot number counter counts horizontal sync signals using analog digital clocks and a dot number comparator checks whether or not the value obtained from the counting matches up with a dot number decoded value. These values are ORed by an OR circuit and the result is output in a form of a mode monitoring detection signal.

摘要翻译： 提供了等离子体显示装置，即使在分辨率被切换时也能够防止图像干扰和施加过大的负载。 垂直频率计数器使用系统时钟对垂直同步信号进行计数，垂直频率比较器检查从计数获得的值是否与垂直频率解码值匹配。 行数计数器使用水平同步信号对垂直同步信号进行计数，行数比较器检查从计数获得的值是否与行号解码值匹配。 点号计数器使用模拟数字时钟对水平同步信号进行计数，并且点数比较器检查从计数获得的值是否与点数解码值匹配。 这些值由OR电路进行或运算，结果以模式监视检测信号的形式输出。