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    Imidazolidinones as brain activators
    3.
    发明授权
    Imidazolidinones as brain activators 失效
    咪唑啉酮作为脑活化剂

    公开(公告)号：US4886817A

    公开(公告)日：1989-12-12

    申请号：US292211

    申请日：1988-12-29

    申请人： Mikio Takeda ,  Masaru Inage ,  Hiroshi Wada ,  Hajime Tamaki ,  Takashi Ochiai

    发明人： Mikio Takeda ,  Masaru Inage ,  Hiroshi Wada ,  Hajime Tamaki ,  Takashi Ochiai

    IPC分类号： A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D417/04

    CPC分类号： C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D417/04

    摘要： This invention relates to imidazolidinone compounds of the formula ##STR1## wherein Q is methylene group or a single bond:R is a heterocyclic group selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl and 1,3-thiazolyl which may be unsubstituted or with a substituent selected from the group consisting of lower alkyl, lower alkoxy and halogen atom, wherein R is bonded to Q or, when Q is a single bond, to the imidazolidinone ring, through the carbon atom of R;the ring A is an unsubstituted phenyl or a substituted phenyl having 1 or 2 substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen, lower alkylthio, trihalogeno-lower alkyl and nitro;Y is vinylene group or ethynylene;m is a integer from 1 to 6 andn is 0, 1 or 2,or a pharmacetically acceptable salt thereof.These compounds aer useful as cerebral activators, anti-depressants and nootropic drugs.

    摘要翻译： 本发明涉及式（I）的咪唑啉酮化合物，其中Q是亚甲基或单键：R是选自吡啶基，哒嗪基，嘧啶基，吡嗪基和1,3-噻唑基的杂环基，其中 可以是未取代的或具有选自低级烷基，低级烷氧基和卤素原子的取代基，其中R与Q键合，或者当Q为单键时，与咪唑啉酮环通过R的碳原子; 环A是未取代的苯基或具有1或2个选自低级烷基，低级烷氧基，卤素，低级烷硫基，三卤代低级烷基和硝基的取代基的取代苯基; Y是亚乙烯基或亚乙炔基; m为1〜6的整数，n为0,1或2，或其药物可接受的盐。 这些化合物可用作脑激活剂，抗抑郁药和益智药。