公开(公告)号：US3936463A

公开(公告)日：1976-02-03

申请号：US421439

申请日：1973-12-03

申请人： Otto Behner ,  Ulrich Horlein ,  Friedrich Hoffmeister ,  Hans Werner Schubert

发明人： Otto Behner ,  Ulrich Horlein ,  Friedrich Hoffmeister ,  Hans Werner Schubert

IPC分类号： C07D221/26

CPC分类号： C07D221/26

摘要： Benzomorphanes of the formula: ##SPC1##WhereinR is cyclopropylmethyl or cyclobutylmethyl;R.sup.1 and R.sup.2 are the same or different and each is lower alkyl;R.sup.3 is hydrogen; a straight, branched or cyclic, saturated, partially unsaturated or unsaturated aliphatic hydrocarbon unsubstituted or substituted by 1 or more substituents selected from the group consisting of lower alkoxy, lower alkoxycarbonyl, lower alkylmercapto, aryloxy, arylmercapto, arylamino, and an acid amide; an unsubstituted or substituted aromatic moiety; an unsubstituted or substituted 5-, 6- or 7-membered heterocyclic ring; lower alkylamino; di(lower alkyl)amino; arylamino; lower alkyl-arylamino; lower alkoxy; urethane; an acid amide; lower alkoxycarbonylamino; or lower alkoxycarbonyl-lower alkylamino; andA is a bivalent, straight- or branched-chain, saturated, partially unsaturated or unsaturated hydrocarbon of 2 to 10 carbon atoms, unsubstituted or substituted by phenyl or by phenyl substituted by at least 1 substituent selected from the group consisting of lower alkyl, lower alkoxy, nitro, amino and halogen,And pharmaceutically acceptable nontoxic salts thereof, are useful as analgesics.

摘要翻译： 苯并吡啶的配方：