公开(公告)号：US20090326897A1

公开(公告)日：2009-12-31

申请号：US12307987

申请日：2007-06-28

申请人： Andreas Schuppert ,  Heidrun Ellinger-Ziegelbauer ,  Hans-Jürgen Ahr

发明人： Andreas Schuppert ,  Heidrun Ellinger-Ziegelbauer ,  Hans-Jürgen Ahr

IPC分类号： G06G7/60 ,  G06F19/00 ,  G06F17/18

CPC分类号： G16B5/00 ,  G16B25/00

摘要： The invention relates to a method for determining the behavior of at least one biological system after a reversible perturbation, comprising the following steps: (a) providing at least one biological system, the biological system comprising a biological network comprising a multiplicity of biological or biochemical components, which have an activity; (b) providing a linear model for describing the behavior of the network of the biological system; (c) determining the activity of the biological or biochemical components of the biological network; (d) reversibly perturbing the activity of at least one of the biological or biochemical components, a reaction of the biological network being generated which is formed by the change in the activity of at least one or more of the biological or biochemical components; (e) determining the activity of the biological or biochemical components of the biological network after exerting the reversible perturbation, as soon as the components of the network have completed the reaction to the perturbation; (f) determining the change in the activity of at least one biological or biochemical component of the biological network as a reaction to the reversible perturbation; (g) calculating the behavior of the biological network with the aid of the linear model provided for describing the behavior of the biological network and the change in the activity of the biological or biochemical component(s) of the biological network after the reversible perturbation as determined in step (f), while taking into account the biodiversity of the reaction of the biological or biochemical component(s); and (h) optionally comparison between the change in the activity of the individual components as determined according to step (f) and the behavior of the biological network as calculated according to step (g) with the aid of the linear model which is provided, there being expected to be a match of the calculated behavior with the change in the activity of the biological or biochemical component(s) as determined in step (f).