公开(公告)号：US20210015757A1

公开(公告)日：2021-01-21

申请号：US16932153

申请日：2020-07-17

申请人： Hardy Wai-Hong CHAN ,  NANO TARGETING & THERAPY BIOPHARMA INC

发明人： Hardy Wai Hong CHAN ,  Chung-Yuan MOU ,  Cheng-Hsun WU ,  Si-Han WU ,  Yi-Ping CHEN ,  Rong-Lin ZHANG

IPC分类号： A61K9/51 ,  A61K31/121 ,  A61K31/704

摘要： The present disclosure relates to mesoporous silica nanoparticles having modifications on the surface of the (extended) mesopores, which can be further loaded with one or more types of bioactive ingredients within the (extended) mesopores mesopores, processes of preparing the same and applications of the same.

公开(公告)号：US20140235465A1

公开(公告)日：2014-08-21

申请号：US13770987

申请日：2013-02-19

申请人： Wen-Yi Chen ,  Yun-Shyong Yang ,  Hardy Wai-Hong Chan

发明人： Wen-Yi Chen ,  Yun-Shyong Yang ,  Hardy Wai-Hong Chan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6832 ,  C12Q2525/113 ,  C12Q2563/116

摘要： A method of using Neutrilized DNA (N-DNA) as a surface probe for a high throughput detection platform is disclosed. FET and SPRi are used as high throughput detection platforms to demonstrate that the N-DNA surface probe produces good results and enhances detection sensitivity. The N-DNA modifies the charged oxygen ions (O−) on the phosphate backbone through methylation, ethylation, propylation, or alkylation, so that the backbone is not charged after this modification to increase the hybridization efficiency, sensitivity and to make the signal more clear.

摘要翻译： 公开了一种使用中性DNA（N-DNA）作为高通量检测平台的表面探针的方法。 FET和SPRi用作高通量检测平台，以证明N-DNA表面探针产生良好的结果并增强检测灵敏度。 N-DNA通过甲基化，乙基化，丙基化或烷基化修饰磷酸酯骨架上的带电氧离子（O-），从而在此修饰后主链不带电以提高杂交效率，灵敏度，使信号更多 明确。