公开(公告)号：US09023318B2

公开(公告)日：2015-05-05

申请号：US13849646

申请日：2013-03-25

申请人： Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

发明人： Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

IPC分类号： A61K51/00 ,  A61M36/14 ,  C07D403/14 ,  C07D405/14 ,  C07D249/04 ,  C07D309/12 ,  C07D213/42

CPC分类号： C07D403/14 ,  C07D213/42 ,  C07D249/04 ,  C07D309/12 ,  C07D405/14

摘要： Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

摘要翻译： 已经公开了具有MMP抑制活性的新型化合物和药物组合物，其已经被发现特别可用于预防，治疗和诊断成像与MMP的非配对活性相关的疾病，其中MMP-2，MMP-8，MMP- 9和/或MMP-13等等。 本发明的化合物可用于预防，治疗和体内诊断成像的一系列疾病状态（炎性，恶性和退行性疾病），其中已知特定的基质金属蛋白酶涉及。

公开(公告)号：US20130217887A1

公开(公告)日：2013-08-22

申请号：US13849646

申请日：2013-03-25

申请人： Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

发明人： Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

IPC分类号： C07D403/14 ,  C07D249/04 ,  C07D405/14

CPC分类号： C07D403/14 ,  C07D213/42 ,  C07D249/04 ,  C07D309/12 ,  C07D405/14

摘要： Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

摘要翻译： 已经公开了具有MMP抑制活性的新型化合物和药物组合物，其已经被发现特别可用于预防，治疗和诊断成像与MMP的非配对活性相关的疾病，其中MMP-2，MMP-8，MMP- 9和/或MMP-13等等。 本发明的化合物可用于预防，治疗和体内诊断成像的一系列疾病状态（炎性，恶性和退行性疾病），其中已知特定的基质金属蛋白酶涉及。