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公开(公告)号：US06169920A
公开(公告)日：2001-01-02
申请号：US08320387
申请日：1994-10-11
申请人： Ronald P. Haak , Robert M. Meyers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , J. Richard Gyory
发明人： Ronald P. Haak , Robert M. Meyers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , J. Richard Gyory
IPC分类号： A61N130
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/303
摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.
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公开(公告)号：US4940586A
公开(公告)日：1990-07-10
申请号：US257487
申请日：1988-10-13
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译： 描述了通过完整皮肤增强透皮递送药物的透皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。 用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。
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公开(公告)号：US4900555A
公开(公告)日：1990-02-13
申请号：US257481
申请日：1988-10-13
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominatly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译： 描述了通过完整皮肤增强透皮递送药物的经皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。 用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。
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公开(公告)号：US4865848A
公开(公告)日：1989-09-12
申请号：US19442
申请日：1987-02-26
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7076 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
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公开(公告)号：US4820720A
公开(公告)日：1989-04-11
申请号：US174932
申请日：1988-03-29
CPC分类号： A61K9/7053 , A61K47/10 , A61K47/14 , A61K9/0014 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： A dosage form that coadministers a drug and two percutaneous absorption enhancers to a defined area of the skin is described. The dosage form comprises a body that contains supplies of drug and enhancers and has a basal surface that contacts the area of skin and transmits the drug and enhancers to the area for absorption thereby.
摘要翻译： 描述了将药物和两个经皮吸收促进剂组合到皮肤的限定区域的剂型。 剂型包括含有药物和增强剂供应的身体，并且具有接触皮肤区域的基底表面并将药物和增强剂传递到所述吸收区域。
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公开(公告)号：US4764379A
公开(公告)日：1988-08-16
申请号：US88767
申请日：1987-08-24
CPC分类号： A61K9/7084 , A61K47/10 , A61K47/14 , A61K9/0014 , Y10S514/946 , Y10S514/947
摘要： A dosage form that coadministers a drug and two percutaneous adsorption enhancers to a defined area of the skin is described. The dosage form comprises a body that contains supplies of drug and enhancers and has a basal surface that contacts the area of skin and transmits the drug and enhancers to the area for absorption thereby.
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公开(公告)号：US06317629B1
公开(公告)日：2001-11-13
申请号：US08351381
申请日：1994-12-02
申请人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
发明人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
IPC分类号： A61N130
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/303
摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.
摘要翻译： 提供了一种离子电渗疗法输送装置（10）。 设备（10）具有电子电路（32），其具有安装在其上的电池（30）等电子部件。 装置（10）还包括一对电极组件（18,19）。 使用导电粘合剂（34）将电子电路（32）电连接到电极组件（18,19）。 粘合剂也可以用于电连接电路（32）内的两个或更多个电子部件或将电子部件连接到电子电路（32）。 在本发明的一个实践中，导电粘合剂（44）用作电极并将电路（32）电连接到含药剂的储存器（24,25）。 在本发明的进一步实践中，导电粘合剂（93）用作试剂储存器并且包含待离子电渗传递的试剂。
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