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公开(公告)号：US20120053175A1
公开(公告)日：2012-03-01
申请号：US13131193
申请日：2009-11-25
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/437 , A61K31/496 , A61P25/24 , A61K31/4985 , A61P25/28 , A61P25/16 , A61P25/00 , A61P27/16 , C07D471/04 , A61K31/506
CPC分类号： A61K31/437 , A61K31/438 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D471/04 , C07D471/10 , C07D487/04 , A61K2300/00
摘要： Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.
摘要翻译： 提供对混合谱系激酶具有抑制作用的化合物。 还提供了药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物的方法，用于治疗受混合谱系激酶抑制影响的疾病和病症。 还提供了治疗包含抑制混合谱系激酶的神经精神障碍的方法。
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2.发明申请Compositions and Methods Relating to Mitochondrial Hyperpolarization in Neurological Disease 审中-公开关于线粒体超极化神经病变的组成和方法公开(公告)号：US20080269161A1
公开(公告)日：2008-10-30
申请号：US11795664
申请日：2006-01-19
IPC分类号： A61K31/708 , C12N5/02 , A61K31/551 , A61K31/4725 , A61K31/427 , A61K31/472 , A61K31/536 , A61K31/444 , A61K31/496 , A61K31/341 , A61K31/513 , A61K31/4402 , A61K31/7072
CPC分类号： A61K31/203 , A61K31/277 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： Provided is a method of protecting a neuron from dysfunction induced by an HIV neurotoxin comprising contacting the cell with a therapeutically effective dose of an inhibitor of mitochondrial hyperpolarization.
摘要翻译： 提供了一种保护神经元免受HIV神经毒素诱导的功能障碍的方法，包括使细胞与治疗有效剂量的线粒体超极化抑制剂接触。
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3.发明申请TREATMENT OF NEUROADS USING INHIBITORS OF GLYCOGEN SYNTHASE KINASE (GSK)-3 审中-公开使用GLYCOGEN SYNTHASE KINASE（GSK）-3抑制剂治疗神经病变公开(公告)号：US20090081318A1
公开(公告)日：2009-03-26
申请号：US12158896
申请日：2006-12-19
CPC分类号： A61K31/195
摘要： Provided is a method of treating or preventing neurological disease in a subject in need of such treatment or prevention, comprising administering to the subject a therapeutically effective dose of a GSK-3 inhibitor.
摘要翻译： 提供了在需要这种治疗或预防的受试者中治疗或预防神经疾病的方法，包括向受试者施用治疗有效剂量的GSK-3抑制剂。
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![Substituted pyrrolo[2,3-B]pyridines as MLK inhibitors](/abs-image/US/2014/11/04/US08877772B2/abs.jpg.150x150.jpg)
公开(公告)号：US08877772B2
公开(公告)日：2014-11-04
申请号：US13131193
申请日：2009-11-25
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , A61K45/06
CPC分类号： A61K31/437 , A61K31/438 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D471/04 , C07D471/10 , C07D487/04 , A61K2300/00
摘要： Provided are compounds having an inhibitory effect on Mixed Lineage Kinases, having a structural Formula, Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.
摘要翻译： 提供具有结构式的对混合谱系激酶具有抑制作用的化合物。还提供了药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物的方法，用于治疗 受混合谱系激酶抑制影响的疾病和病症。 还提供了治疗包含抑制混合谱系激酶的神经精神障碍的方法。
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5.发明申请CHEMICAL PRECONDITIONING AS A PREVENTATIVE OR TREATMENT FOR EXCITOTOXIC SYNAPTIC DAMAGE 审中-公开化学预防作为预防或治疗爆发性致死性损伤公开(公告)号：US20090221651A1
公开(公告)日：2009-09-03
申请号：US12092110
申请日：2006-10-30
IPC分类号： A61K31/4406 , C12Q1/02 , A61P25/00
CPC分类号： A61K31/4406
摘要： A method of preventing HIV-1 associated dendritic pathology in a brain cell, comprising contacting the cell with a therapeutically effective dose of a mitochondrial ATP-sensitive potassium channel agonist. A method of preventing HIV-1 associated dendritic pathology in a brain cell, comprising contacting the cell with a therapeutically effective dose of an inhibitor of succinate dehydrogenase. A method of preventing HIV-1 associated dendritic pathology in a brain cell, comprising contacting the cell with a therapeutically effective dose of a stimulator of production of reactive oxygen species. A model for the study of HIV-1 associated dendritic pathology, comprising a) contacting a hippocampal slice with platelet-activating factor; and b) stimulating the hippocampal slice of a) with high frequency stimulation.
摘要翻译： 一种在脑细胞中预防HIV-1相关的树突状病理学的方法，包括使细胞与治疗有效剂量的线粒体ATP敏感钾通道激动剂接触。 一种预防脑细胞中HIV-1相关的树突状病理学的方法，包括使细胞与治疗有效剂量的琥珀酸脱氢酶抑制剂接触。 一种在脑细胞中预防HIV-1相关的树突状病理学的方法，包括使细胞与治疗有效剂量的活性氧产生的刺激物接触。 用于研究HIV-1相关树突状病理学的模型，包括a）使海马切片与血小板活化因子接触; 和b）用高频刺激刺激a）的海马切片。
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公开(公告)号：US08846909B2
公开(公告)日：2014-09-30
申请号：US13698829
申请日：2011-05-24
申请人： Harris A. Gelbard , Stephen Dewhurst , Val S. Goodfellow , Torsten Wiemann , Satheesh Babu Ravula , Colin J. Loweth
发明人： Harris A. Gelbard , Stephen Dewhurst , Val S. Goodfellow , Torsten Wiemann , Satheesh Babu Ravula , Colin J. Loweth
IPC分类号： C07D413/00 , A61K31/44
CPC分类号： A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04 , C07D519/00
摘要： Provided are compounds having an inhibitory effect on kinases including Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders that comprise the inhibition of Mixed Lineage Kinases.
摘要翻译： 提供对对包括混合谱系激酶在内的激酶具有抑制作用的化合物。 还提供了药物组合物，制备化合物的方法，合成中间体以及独立地或与其它治疗剂组合使用该化合物的方法，用于治疗受混合谱系激酶抑制影响的疾病和病症。 还提供了治疗包含抑制混合谱系激酶的神经精神障碍的方法。
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公开(公告)号：US20150105401A1
公开(公告)日：2015-04-16
申请号：US14508566
申请日：2014-10-07
IPC分类号： C07D471/04
CPC分类号： A61K31/437 , A61K31/438 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D471/04 , C07D471/10 , C07D487/04 , A61K2300/00
摘要： Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.
摘要翻译： 提供对混合谱系激酶具有抑制作用的化合物。 还提供了药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物的方法，用于治疗受混合谱系激酶抑制影响的疾病和病症。 还提供了治疗包含抑制混合谱系激酶的神经精神障碍的方法。
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公开(公告)号：US20130203755A1
公开(公告)日：2013-08-08
申请号：US13698829
申请日：2011-05-24
申请人： Harris A. Gelbard , Stephen Dewhurst , Val S. Goodfellow , Torsten Wiemann , Satheesh Babu Ravula , Colin J. Loweth
发明人： Harris A. Gelbard , Stephen Dewhurst , Val S. Goodfellow , Torsten Wiemann , Satheesh Babu Ravula , Colin J. Loweth
IPC分类号： A61K31/437 , A61K31/444 , A61K31/496 , A61K45/06 , C07D487/04 , A61K31/4985 , A61K31/5377 , C07D471/04 , A61K31/506
CPC分类号： A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04 , C07D519/00
摘要： Provided are compounds having an inhibitory effect on kinases including Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders that comprise the inhibition of Mixed Lineage Kinases.
摘要翻译： 提供对对包括混合谱系激酶在内的激酶具有抑制作用的化合物。 还提供了药物组合物，制备化合物的方法，合成中间体以及独立地或与其它治疗剂组合使用该化合物的方法，用于治疗受混合谱系激酶抑制影响的疾病和病症。 还提供了治疗包含抑制混合谱系激酶的神经精神障碍的方法。
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